HST observations have revealed that compact sources exist at the centers of many, maybe even most, galaxies across the Hubble sequence. These sources are called “nuclei” or also “nuclear star clusters” (NCs), given that their structural properties and position in the fundamental plane are similar to those of globular clusters. Interest in NCs increased recently due to the independent and contemporaneous finding of three groups (Rossa et al. for spiral galaxies; Wehner & Harris for dE galaxies; and Côté et al. for elliptical galaxies) that NC masses obey similar scaling relationships with host galaxy properties as do supermassive black holes. Here we summarize the results of our group on NCs in spiral galaxies. We discuss the implications for our understanding of the formation and evolution of NCs and their possible connection to supermassive black holes.