Excessive responsibility has been proposed as a cognitive factor in obsessive-compulsive symptoms. In the present study the relationships of Salkovskis' measure of Responsibility Attitudes (RAS) (Salkovskis et al., 2000) with the total scale and the subscales of the PI-WSUR (Burns, Koertge, Formea, & Sternberger, 1996) measure of obsessive compulsive symptoms, as well as with a measure of depression (CES-D), were studied with a sample of 356 students (108 males and 248 females). As expected, the correlation between RAS and PI-WSUR was stronger than the correlation between RAS and CES-D, supporting the specific role of excessive responsibility in obsessive-compulsive symptoms. Among the subscales of PI-SWUR the strongest correlation of RAS was with Obsessional Thoughts About Harm to Self/Others (OTAHSO) and then with Checking. The OTAHSO was the only PI-WSUR subscale to show a significant partial correlation with RAS when other subscales and CES-D scores were taken into consideration. These results indicate that responsibility attitudes may play quite different roles in relation to different obsessive-compulsive symptom domains and that cognitive theory should take this more explicitly into account.