To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Disturbed sleep and activity are prominent features of bipolar disorder type I (BP-I). However, the relationship of sleep and activity characteristics to brain structure and behavior in euthymic BP-I patients and their non-BP-I relatives is unknown. Additionally, underlying genetic relationships between these traits have not been investigated.
Relationships between sleep and activity phenotypes, assessed using actigraphy, with structural neuroimaging (brain) and cognitive and temperament (behavior) phenotypes were investigated in 558 euthymic individuals from multi-generational pedigrees including at least one member with BP-I. Genetic correlations between actigraphy-brain and actigraphy-behavior associations were assessed, and bivariate linkage analysis was conducted for trait pairs with evidence of shared genetic influences.
More physical activity and longer awake time were significantly associated with increased brain volumes and cortical thickness, better performance on neurocognitive measures of long-term memory and executive function, and less extreme scores on measures of temperament (impulsivity, cyclothymia). These associations did not differ between BP-I patients and their non-BP-I relatives. For nine activity-brain or activity-behavior pairs there was evidence for shared genetic influence (genetic correlations); of these pairs, a suggestive bivariate quantitative trait locus on chromosome 7 for wake duration and verbal working memory was identified.
Our findings indicate that increased physical activity and more adequate sleep are associated with increased brain size, better cognitive function and more stable temperament in BP-I patients and their non-BP-I relatives. Additionally, we found evidence for pleiotropy of several actigraphy-behavior and actigraphy-brain phenotypes, suggesting a shared genetic basis for these traits.
Studies have produced conflicting evidence regarding whether cognitive
control deficits in patients with schizophrenia result from dysfunction
within the cognitive control network (CCN; top-down) and/or unisensory
To investigate CCN and sensory cortex involvement during multisensory
cognitive control in patients with schizophrenia.
Patients with schizophrenia and healthy controls underwent functional
magnetic resonance imaging while performing a multisensory Stroop task
involving auditory and visual distracters.
Patients with schizophrenia exhibited an overall pattern of response
slowing, and these behavioural deficits were associated with a pattern of
patient hyperactivation within auditory, sensorimotor and posterior
parietal cortex. In contrast, there were no group differences in
functional activation within prefrontal nodes of the CCN, with small
effect sizes observed (incongruent–congruent trials). Patients with
schizophrenia also failed to upregulate auditory cortex with concomitant
increased attentional demands.
Results suggest a prominent role for dysfunction within auditory,
sensorimotor and parietal areas relative to prefrontal CCN nodes during
multisensory cognitive control.
Email your librarian or administrator to recommend adding this to your organisation's collection.