This work investigates the spatio-temporal evolution of coherent structures in the wake of a generic high-speed train, based on a three-dimensional database from large eddy simulation. Spectral proper orthogonal decomposition (SPOD) is used to extract energy spectra and energy ranked empirical modes for both symmetric and antisymmetric components of the fluctuating flow field. The spectrum of the symmetric component shows overall higher energy and more pronounced low-rank behaviour compared with the antisymmetric one. The most dominant symmetric mode features periodic vortex shedding in the near wake, and wave-like structures with constant streamwise wavenumber in the far wake. The mode bispectrum further reveals the dominant role of self-interaction of the symmetric component, leading to first harmonic and subharmonic triads of the fundamental frequency, with remarkable deformation of the mean field. Then, the stability of the three-dimensional wake flow is analysed based on two-dimensional local linear stability analysis combined with a non-parallelism approximation approach. Temporal stability analysis is first performed for both the near-wake and the far-wake regions, showing a more unstable condition in the near-wake region. The absolute frequency of the near-wake eigenmode is determined based on spatio-temporal analysis, then tracked along the streamwise direction to find out the global mode growth rate and frequency, which indicate a marginally stable global mode oscillating at a frequency very close to the most dominant SPOD mode. The global mode wavemaker is then located, and the structural sensitivity is calculated based on the direct and adjoint modes derived from a local spatial analysis, with the maximum value localized within the recirculation region close to the train tail. Finally, the global mode shape is computed by tracking the most spatially unstable eigenmode in the far wake, and the alignment with the SPOD mode is computed as a function of streamwise location. By combining data-driven and theoretical approaches, the mechanisms of coherent structures in complex wake flows are well identified and isolated.

This study presents an approach to investigate the role of eddy viscosity in linearized mean-field analysis of broadband turbulent flows. The procedure is based on spectral proper orthogonal decomposition (SPOD), resolvent analysis and the energy budget of coherent structures and is demonstrated using the example of a turbulent jet. The focus is on the coherent component of the Reynolds stresses, the nonlinear interaction term of the fluctuating velocity component in frequency space, which appears as an unknown in the derivation of the linearized Navier–Stokes equations and which is the quantity modelled by the Boussinesq approach. For the considered jet the coherent Reynolds stresses are found to have a mostly dissipative effect on the energy budget of the dominant coherent structures. Comparison of the energy budgets of SPOD and resolvent modes demonstrates that dissipation caused by nonlinear energy transfer must be explicitly considered within the linear operator to achieve satisfactory results with resolvent analysis. Non-modelled dissipation distorts the energy balance of the resolvent modes and is not, as often assumed, compensated for by the resolvent forcing vector. A comprehensive analysis, considering different predictive and data-driven eddy viscosities, demonstrates that the Boussinesq model is highly suitable for modelling the dissipation caused by nonlinear energy transfer for the considered flow. Suitable eddy viscosities are analysed with regard to their frequency, azimuthal wavenumber and spatial dependence. In conclusion, the energetic considerations reveal that the role of eddy viscosity is to ensure that the energy the structures receive from the mean-field is dissipated.

Egalitarian theories assess when and why distributive inequalities are objectionable. How should egalitarians assess inequalities between generations? One egalitarian theory is (telic) distributive egalitarianism: other things being equal, equal distributions of some good are intrinsically better than unequal distributions. I first argue that distributive egalitarianism produces counterintuitive judgements when applied across generations and that attempts to discount or exclude intergenerational inequalities do not work. This being so, intergenerational comparisons also undercut the intragenerational judgements that made distributive egalitarianism intuitive in the first place. I then argue that egalitarians should shed distributive egalitarianism: relational and instrumental arguments against inequality likely suffice to capture egalitarian concerns – including across generations – without encountering the problems produced by distributive egalitarianism.

The small angle X-ray scattering data obtained in an earlier investigation of a series of Na-montmorillonite clay samples containing varying concentrations of sodium metaphosphate have been used to calculate the potential energy φ(x) of the interaction between two isolated parallel clay platelets separated by a distance x. All φ(x) curves have the form expected for Na-montmorillonite. In each curve there is a potential well for a platelet separation approximately equal to the most probable separation distance determined in the earlier study. Because the depth of the potential well is of the order of 0·01 eV for all samples, the attractive forces are relatively weak. While the calculated φ(x) functions are not highly accurate, in future investigations precautions can be taken to increase the reliability of the computed potential energy functions. This preliminary study suggests that determination of φ(x) from small angle X-ray scattering data can be a useful method for quantitative study of interparticle forces in Na-montmorillonite clays.

Background: Blood loss quantification and management are important facets of cranial surgery, having been linked with adverse outcomes if management is inadequate. While many studies report estimated blood loss (EBL) as an outcome measure, inconsistencies exist in EBL quantification and management strategies Methods: A systematic review of cranial surgery literature on blood loss measurement and management was conducted according to PRISMA guidelines utilizing a novel software platform, Nested Knowledge Results: Initial search yielded 1029 non-duplicated. 107 full-text studies were included. 70% of studies were retrospective. Most common treatment conditions were 41% craniosynostosis (44/107) and 36% tumor (39/107). Most common EBL measurement methods were comparison of pre-operative and post-operative hemoglobin/hematocrit in 46.7% (50/107), anesthesia record in 26.2% (28/107), and surgeon estimation in 9.3% (10/107). 53.3% of studies did not specify a quantification methodology. Blood loss management strategies also varied, with transfusion being the most common method in 64.5% (69/107) of studies Conclusions: EBL quantification and blood loss management remain important clinical and research metrics. Despite this, significant heterogeneity exists in blood loss quantification and management strategies, with most studies providing no data on EBL quantification. Standardization of EBL quantification/reporting should be undertaken to improve comparability and consistency across studies.

Background: Duchenne muscular dystrophy (DMD) is caused by DMD gene mutations. Delandistrogene moxeparvovec is an investigational gene transfer therapy, developed to address the underlying cause of DMD. We report findings from Part 1 (52 weeks) of the two-part EMBARK trial (NCT05096221). Methods: Key inclusion criteria: Ambulatory patients aged ≥4-<8 years with a confirmed DMD mutation within exons 18–79 (inclusive); North Star Ambulatory Assessment (NSAA) score >16 and <29 at screening. Eligible patients were randomized 1:1 to intravenous delandistrogene moxeparvovec (1.33×1014 vg/kg) or placebo. The primary endpoint was change from baseline in NSAA total score to Week 52. Results: At Week 52 (n=125), the primary endpoint did not reach statistical significance, although there was a nominal difference in change from baseline in NSAA total score in the delandistrogene moxeparvovec (2.6, n=63) versus placebo groups (1.9, n=61). Key secondary endpoints (time to rise, micro-dystrophin expression, 10-meter walk/run) demonstrated treatment benefit in both age groups (4-5 and 6-7 years; p<0.05).There were no new safety signals, reinforcing the favorable and manageable safety profile observed to date. Conclusions: Based on the totality of functional assessments including the timed function tests, treatment with delandistrogene moxeparvovec indicates beneficial modification of disease trajectory.

Limited analyses based on national samples have assessed whether early attention-deficit/hyperactivity disorder (ADHD) symptoms predict later internalizing and externalizing symptoms in youth and the influence of sex and pubertal timing on subsequent psychiatric symptoms. This study analyzed data (n = 2818) from the Environmental influences on Child Health Outcomes Program national cohort. Analyses used data from early childhood (mean age = 5.3 years) utilizing parent-reported ADHD symptoms to predict rates of internalizing and externalizing symptoms from late childhood/adolescence (mean age = 11.9 years). Within a subsample age at peak height velocity (APHV) acted as a proxy to assess pubertal timing from early childhood (mean age = 5.4 years) to adolescence (mean age = 12.3 years). Early-childhood ADHD symptoms predicted later psychiatric symptoms, including anxiety, depression, aggressive behavior, conduct problems, oppositional defiant disorder, and rule-breaking behavior. Earlier APHV was associated with increased Conduct Disorder symptoms from late childhood to adolescence for females only. A stronger relation between ADHD symptoms and later aggression was observed in females with earlier APHV, whereas this same pattern with aggression, conduct problems and depression was observed in males with later APHV. Clinicians should consider that both young girls and boys with elevated ADHD symptoms, particularly with off-set pubertal timing, may be at risk for later psychiatric symptoms.

A turbulent circular disk wake database (Chongsiripinyo & Sarkar, J. Fluid Mech., vol. 885, 2020) at Reynolds number $Re = U_\infty D/\nu = 5 \times 10^{4}$ is interrogated to identify the presence of large-scale streaks – coherent elongated regions of streamwise velocity. The unprecedented streamwise length – until $x/D \approx 120$ – of the simulation enables investigation of the near and far wakes. The near wake is dominated by the vortex shedding (VS) mode residing at azimuthal wavenumber $m=1$ and Strouhal number $St = 0.135$. After filtering out the VS structure, conclusive evidence of large-scale streaks with frequency $St \rightarrow 0$, equivalently streamwise wavenumber $k_x \rightarrow 0$ in the wake, becomes apparent in visualizations and spectra. These streaky structures are found throughout the simulation domain beyond $x/D \approx 10$. Conditionally averaged streamwise vorticity fields reveal that the lift-up mechanism is active in the near as well as the far wake, and that ejections contribute more than sweeps to events of intense $-u'_xu'_r$. Spectral proper orthogonal decomposition is employed to extract the energy and the spatiotemporal features of the large-scale streaks. The streak energy is concentrated in the $m=2$ azimuthal mode over the entire domain. Finally, bispectral mode decomposition is conducted to reveal strong interaction between $m=1$ and $St = \pm 0.135$ modes to give the $m=2$, $St \rightarrow 0$ streak mode. Our results indicate that the self-interaction of the VS mode generates the $m=2$, $St \rightarrow 0$ streamwise vortices, which leads to streak formation through the lift-up process. To the authors’ knowledge, this is the first study that reports and characterizes large-scale low-frequency streaks and the associated lift-up mechanism in a turbulent wake.

Previous studies have shown that the analysis of high frequency stress calls in pigs can serve as a reliable tool in welfare research. Our study focuses on the classification of three different classes of piglet vocalisation: grunting, squealing and screaming. In a castration experiment (Experiment 1), 3,285 vocalisations from 42 piglets were analysed for 21 different vocal characteristics. A first discriminant function for the three vocal types was derived from recordings made under laboratory-like conditions. A second discriminant function was derived from non-calibrated measurements of the relative sound energy content. These two classifications revealed 86.7% identical assignments of vocalisations to the three vocal types. The second classification allowed for vocalisation analyses of animals under on-farm recording conditions. This technique was validated during an open-field test (Experiment 2) with piglets housed in two different farrowing systems (11,089 vocalisations, 22 piglets). The proportion of screaming sounds was lower for piglets from a group-farrowing (GF) system than for those from a single-farrowing (SF) system. Sound properties showed differences between as well as within the two experiments for all three vocal types. Vocalisations from SF and GF piglets differed significantly in the duration, energy, and relative maximum levels. We conclude that vocal-type analysis can not only help to identify vocalisation indicative of pain during castration, but also vocal behaviour changes indicating separation stress during the open-field test. Therefore, classification of vocal types can add valuable information to studies that use pig vocalisation for the assessment of welfare.

The COVID-19 pandemic has harmed many people's mental health globally. Whilst the evidence generated thus far from high-income countries regarding the pandemic's impact on suicide rates is generally reassuring, we know little about its influence on this outcome in lower- and middle-income countries or among marginalised and disadvantaged people. There are some signals for concern regarding the pandemic's potentially unequal impact on suicide rates, with some of the affected demographic subgroups and regions being at elevated risk before the pandemic began. However, the evidence-base for this topic is currently sparse, and studies conducted to date have generally not taken account of pre-pandemic temporal trends. The collection of accurate, complete and comparable data on suicide rate trends in ethnic minority and low-income groups should be prioritised. The vulnerability of low-income groups will likely be exacerbated further by the current energy supply and cost-of-living crises in many countries. It is therefore crucial that reassuring messaging highlighting the stability of suicide rates during the pandemic does not lead to complacency among policymakers.

We use spectral proper orthogonal decomposition (SPOD) to extract and analyse coherent structures in the turbulent wake of a disk at Reynolds number $ {\textit {Re}} = 5 \times 10^{4}$ and Froude numbers $ {\textit {Fr}} = 2$, 10. We find that the SPOD eigenspectra of both wakes exhibit a low-rank behaviour and the relative contribution of low-rank modes to total fluctuation energy increases with $x/D$. The vortex shedding (VS) mechanism, which corresponds to $ {\textit {St}} \approx 0.11 - 0.13$ in both wakes, is active and dominant throughout the domain in both wakes. The continual downstream decay of the SPOD eigenspectrum peak at the VS mode, which is a prominent feature of the unstratified wake, is inhibited by buoyancy, particularly for $ {\textit {Fr}} = 2$. The energy at and near the VS frequency is found to appear in the outer region of the wake when the downstream distance exceeds $Nt = Nx/U = 6 - 8$. Visualizations show that unsteady internal gravity waves (IGWs) emerge at the same $Nt = 6 - 8$. A causal link between the VS mechanism and the unsteady IGW generation is also established using the SPOD-based reconstruction and analysis of the pressure transport term. These IGWs are also picked up in SPOD analysis as a structural change in the shape of the leading SPOD eigenmode. The $ {\textit {Fr}} = 2$ wake shows layering in the wake core at $Nt > 15$ which is captured by the leading SPOD eigenmodes of the VS frequency at downstream locations $x/D > 30$. The VS mode of the $ {\textit {Fr}} = 2$ wake is streamwise coherent, consisting of $V$-shaped structures at $x/D \gtrsim 30$. Overall, we find that the coherence of wakes, initiated by the VS mode at the body, is prolonged by buoyancy to far downstream. Also, this coherence is spatially modified by buoyancy into horizontal layers and IGWs. Low-order truncations of SPOD modes are shown to efficiently reconstruct important second-order statistics.

Background: Competitive flow diversion (CFD) is a novel application of flow diversion stenting (FDS), redirecting flow into a normal artery proximal or distal to the aneurysmal parent artery. A classification system for CFD has not been previously reported. Methods: Report of operative technique and novel classification system for CFD. Results: A patient with subarachnoid haemorrhage and three aneurysms arising from the Pcomm-P1 complex, was treated with endovascular coiling and CFD. The PCOM aneurysm was coiled. Two aneurysms arose from the distal right P1- PCA. After a failed attempt to treat with FDS across the P1-PCA, the P1-aneurysms were successfully treated with CFD distal to the P1-PCA, from Pcomm to P2. Over 12 months, CFD redirected flow via ICA-Pcomm-P2, reducing the size of the P1-PCA, obliterating the P1-aneurysms. Herein, we classify competitive flow diversion into two types. Type I CFD is when the parent artery harbouring the aneurysm is “jailed” proximally. Type II CFD occurs when flow is diverted from the parent artery distal to the aneurysm origin. Conclusions: Herein, we propose a novel classification for CFD. We describe the first case of aneurysm occlusion in the circle of Willis with Type II CFD, and use of CFD for the treatment of multiple adjacent aneurysms.