Weed control in corn has traditionally relied on atrazine as a foundational tool to control problematic weeds. However, the recent discovery of atrazine in aquifers and other water sources increases the likelihood of more strict restrictions on its use. Therefore, field-based research trials to find atrazine alternatives were conducted in 2017 and 2018 in Fayetteville, Arkansas, by testing the tolerance of corn to PRE and POST applications of different photosystem II (PSII) inhibitors alone or in combination with mesotrione or S-metolachlor. All experiments were designed as a two-factor factorial, randomized complete block with the two factors being 1) PSII-inhibiting herbicide and 2) the herbicide added to create the mixture. The PSII-inhibiting herbicides were prometryn, ametryn, simazine, fluometuron, metribuzin, linuron, diuron, atrazine, and propazine. The second factor consisted of either no additional herbicide, S-metolachlor, or mesotrione. Treatments were applied immediately following planting in the PRE experiments and at 30-cm tall corn for the POST experiments. For the PRE study, low levels of injury (<15%) were observed at 14 and 28 days after application (DAA) and corn height was negatively affected by the PSII-inhibiting herbicide applied. PRE-applied fluometuron- and ametryn-containing treatments consistently caused injury to corn, often exceeding 5%. Due to low levels of injury caused by all treatments, crop density and yield did not differ from the nontreated. For the POST study, crop injury, relative height, and relative yield were all impacted by PSII-inhibiting herbicide and herbicide added. Ametryn-, diuron-, linuron-, propazine-, and prometryn-containing treatments caused ≥25% injury to corn in at least one site-year. All PSII-inhibiting herbicides, except metribuzin and simazine when applied alone, caused yield loss in corn when compared to atrazine alone. Diuron-, linuron-, metribuzin-, and simazine-containing treatments applied PRE and metribuzin- and simazine-containing treatments applied POST should be further investigated as atrazine replacements.