Space Infrared Telescope for Cosmology and Astrophysics (SPICA), the cryogenic infrared space telescope recently pre-selected for a ‘Phase A’ concept study as one of the three remaining candidates for European Space Agency (ESA's) fifth medium class (M5) mission, is foreseen to include a far-infrared polarimetric imager [SPICA-POL, now called B-fields with BOlometers and Polarizers (B-BOP)], which would offer a unique opportunity to resolve major issues in our understanding of the nearby, cold magnetised Universe. This paper presents an overview of the main science drivers for B-BOP, including high dynamic range polarimetric imaging of the cold interstellar medium (ISM) in both our Milky Way and nearby galaxies. Thanks to a cooled telescope, B-BOP will deliver wide-field 100–350 $\mu$ m images of linearly polarised dust emission in Stokes Q and U with a resolution, signal-to-noise ratio, and both intensity and spatial dynamic ranges comparable to those achieved by Herschel images of the cold ISM in total intensity (Stokes I). The B-BOP 200 $\mu$ m images will also have a factor $\sim $ 30 higher resolution than Planck polarisation data. This will make B-BOP a unique tool for characterising the statistical properties of the magnetised ISM and probing the role of magnetic fields in the formation and evolution of the interstellar web of dusty molecular filaments giving birth to most stars in our Galaxy. B-BOP will also be a powerful instrument for studying the magnetism of nearby galaxies and testing Galactic dynamo models, constraining the physics of dust grain alignment, informing the problem of the interaction of cosmic rays with molecular clouds, tracing magnetic fields in the inner layers of protoplanetary disks, and monitoring accretion bursts in embedded protostars.

Globally, the prevalence of tuberculosis (TB) disease is higher in males. This study examined the effect of sex and age on Mycobacterium tuberculosis (Mtb) infection. Demographic and exposure data were collected on household contacts of sputum smear-positive pulmonary TB patients in Brazil. Contacts with tuberculin skin test induration ⩾10 mm at baseline or 12 weeks were considered Mtb infected. The study enrolled 917 household contacts from 160 households; 508 (55.4%) were female, median age was 21.0 years (range 0.30–87.0) and 609 (66.4%) had Mtb infection. The proportion infected increased with age from 63.3% in girls <5 years to 75.4% in women ⩾40 years and from 44.9% in boys <5 years to 73.6% in men ⩾40 years. Multivariable modelling showed the odds of infection increased between age 5 and 14 years among female contacts (OR 1.5 per 5-year age increase; 95% CI 1.1–2.2; P = 0.02) and between ages 0–4 and 15–39 years among male contacts (OR 2.7, 95% CI 0.83–8.9 and 1.1, 95% CI 0.99–1.3 per 5-year age increase; P = 0.10, 0.07, respectively). The study suggests that the age at which Mtb infection increases most is different in females compared with males. Studies are needed to explore whether these findings are due to differences in host susceptibility, exposure outside the household or other factors.

To understand increasing rates of hepatitis C virus (HCV) infection in Tennessee, we conducted testing, risk factor analysis and a nested case–control study among persons who use drugs. During June–October 2016, HCV testing with risk factor assessment was conducted in sexually transmitted disease clinics, family planning clinics and an addiction treatment facility in eastern Tennessee; data were analysed by using multivariable logistic regression. A nested case–control study was conducted to assess drug-using risks and behaviours among persons who reported intranasal or injection drug use (IDU). Of 4753 persons tested, 397 (8.4%) were HCV-antibody positive. HCV infection was significantly associated with a history of both intranasal and IDU (adjusted odds ratio (aOR) 35.4, 95% confidence interval (CI) 24.1–51.9), IDU alone (aOR 52.7, CI 25.3–109.9), intranasal drug use alone (aOR 2.6, CI 1.8–3.9) and incarceration (aOR 2.7, CI 2.0–3.8). By 4 October 2016, 574 persons with a reported history of drug use; 63 (11%) were interviewed further. Of 31 persons who used both intranasal and injection drugs, 26 (84%) reported previous intranasal drug use, occurring 1–18 years (median 5.5 years) before their first IDU. Our findings provide evidence that reported IDU, intranasal drug use and incarceration are independent indicators of risk for past or present HCV infection in the study population.

The SPICA mid- and far-infrared telescope will address fundamental issues in our understanding of star formation and ISM physics in galaxies. A particular hallmark of SPICA is the outstanding sensitivity enabled by the cold telescope, optimised detectors, and wide instantaneous bandwidth throughout the mid- and far-infrared. The spectroscopic, imaging, and polarimetric observations that SPICA will be able to collect will help in clarifying the complex physical mechanisms which underlie the baryon cycle of galaxies. In particular, (i) the access to a large suite of atomic and ionic fine-structure lines for large samples of galaxies will shed light on the origin of the observed spread in star-formation rates within and between galaxies, (ii) observations of HD rotational lines (out to ~10 Mpc) and fine structure lines such as [C ii] 158 μm (out to ~100 Mpc) will clarify the main reservoirs of interstellar matter in galaxies, including phases where CO does not emit, (iii) far-infrared spectroscopy of dust and ice features will address uncertainties in the mass and composition of dust in galaxies, and the contributions of supernovae to the interstellar dust budget will be quantified by photometry and monitoring of supernova remnants in nearby galaxies, (iv) observations of far-infrared cooling lines such as [O i] 63 μm from star-forming molecular clouds in our Galaxy will evaluate the importance of shocks to dissipate turbulent energy. The paper concludes with requirements for the telescope and instruments, and recommendations for the observing strategy.

This study aimed to determine prevalence of Ralstonia spp. in cystic fibrosis patients, look for any evidence of cross infection and to describe clinical outcomes for patients infected by Ralstonia spp. Prevalence of Ralstonia spp. was calculated annually from 2008 to 2016. Pulsed-field gel electrophoresis was performed on ⩾1 sample from patients with an isolation of Ralstonia spp. between 2008 and 2016. A prospective, longitudinal observational study of adult patients was performed with 12 months follow-up from recruitment. Prevalence of Ralstonia spp. rose from 0·6% in 2008 to 2·4% in 2016. In total 12 out of 14 (86%) patients with ⩾1 isolation of Ralstonia spp. developed chronic infection. A pair and a group of three unrelated patients with epidemiological connections shared strains of Ralstonia mannitolilytica. Lung function of Ralstonia spp. infected patients was moderately to severely impaired. Prevalence of Ralstonia spp. is low but increasing. The risk of a patient developing chronic Ralstonia spp. infection following first acquisition is high and cross-infection may be possible. Whether Ralstonia spp. infection causes increased pulmonary exacerbation frequency and lung function decline needs to be evaluated in larger prospective studies.

We present a simple model for the formation of elliptical galaxies, based on a binary clustering hierarchy of dark matter, the chemical enrichment of the gas at each level being controlled by supernovae. The initial conditions for the non-linear phases of galaxy formation are set by the post-recombination power spectrum of density fluctuations. We investigate two models for this power spectrum - the first is a straightforward power law, |δ k |2 ∝ k n , and the second is Peeble's analytic approximation to the emergent spectrum in a universe dominated by cold dark matter. The normalisation is chosen such that on some scale, say M ∼ 1012 M ⊙, the objects that condense out have properties - radius and velocity dispersion - resembling ‘typical’ galaxies. There is some ambiguity in this due to the poorly determined mass-to-light ratio of a typical elliptical galaxy — we look at two normalisations, σ1D ∼ 350kms−1 and σ1D ∼ 140kms−1. The choice determines which of Compton cooling or hydrogen cooling is more important during the galaxy formation period. The non-linear behaviour of the perturbations is treated by the homogeneous sphere approximation.

The formation of disc galaxies is generally believed to involve the dissipative collapse of primordial gas clouds, moving in the potentials of dark, self-gravitating massive halos. Until now, most theories have considered only spherically symmetric collapse, with the luminous disc being formed out of a plane of cold gas which is in centrifugal equilibrium. However, it is unlikely that the halo potential will in fact be spherical.

In the 1998-99 flight, BOOMERanG has produced maps of ∼4% of the sky at high Galactic latitudes, at frequencies of 90, 150, 240 and 410 GHz, with resolution ≳ 10'. The faint structure of the Cosmic Microwave Background at horizon and sub-horizon scales is evident in these maps. These maps compare well to the maps recently obtained at lower frequencies by the WMAP experiment. Here we compare the amplitude and morphology of the structures observed in the two sets of maps. We also outline the polarization sensitive version of BOOMERanG, which was flown early this year to measure the linear polarization of the microwave sky at 150, 240 and 350 GHz.

Marine upwelling along coastal Peru can be intense and variable, making radiocarbon dating marine and coastal systems complex. Historical and proxy records of upwelling along coastal Peru are few, and long-lived species such as corals do not grow in the cold coastal waters. Mollusk shell carbonate, however, can record both the magnitude of the local marine reservoir correction, ΔR, and of seasonal oscillations in the ventilation age of coastal waters. If large, these seasonal oscillations would complicate radiocarbon dating of marine organisms. To examine this possibility, we sampled for δ13C, δ18O, and 14C content a set of pre-bomb Argopecten purpuratus shells collected from coastal Peru during 1908 and 1926. Intrashell variations of up to 216 14C yr were noted, but these were not consistently correlated with seasonal changes in δ18O or δ13C. Only an 11 yr difference was observed in the weighted average ΔR of Callao Bay shells collected during normal (1908) and El Niño (1926) years. Despite the intrashell 14C variation noted, weighted average ΔR values from all 3 sample sites and from normal and El Niño years all overlap at 1 σ. We report ΔR values of 183 ± 18 and 194 ± 23 yr from Callao Bay (12°4′S), 165 ± 24 yr from Salaverry (8°14′S), and 189 ± 23 yr from Sechura Bay (5°45′S).

Mollusk shells provide brief (<5 yr per shell) records of past marine conditions, including marine radiocarbon reservoir age (R) and upwelling. We report 21 14C ages and R calculations on small (∼2 mg) samples from 2 Mesodesma donacium (surf clam) shells. These shells were excavated from a semi-subterranean house floor stratum 14C dated to 7625 ± 35 BP at site QJ-280, Quebrada Jaguay, southern Peru. The ranges in marine 14C ages (and thus R) from the 2 shells are 530 and 170 14C yr; R from individual aragonite samples spans 130 ± 60 to 730 ± 170 14C yr. This intrashell 14C variability suggests that 14C dating of small (time-slice much less than 1 yr) marine samples from a variable-R (i.e. variable-upwelling) environment may introduce centuries of chronometric uncertainty.

We describe preliminary results from our study of multi-scale structures in Centaurus A (NGC 5128) obtained using the Chandra X-ray Observatory HRC-I observations. The high-angular resolution Chandra images reveal X-ray multi-scale structures in this object with unprecedented detail and clarity. The region surrounding the Cen A nucleus, believed to be associated with a supermassive black hole, shows structures on arcsecond scales clearly resolved from the central source.

We have just completed the observational stage of a 2·4 GHz survey of the Southern Galactic Plane, using the Parkes radiotelescope, between 238° ≤ l ≤ 365° and with a latitude range of at least |b| ≤ 5° (beamwidth ~9 arcmin). The survey details both continuum emission and linear polarisation down to rms noises of approximately 12 and 4 mJy/beam respectively. It is the most sensitive survey to date of the southern plane at this frequency and should nicely complement the Effelsberg northern plane surveys in addition to the recent southern surveys such as the 843 MHz MOST survey and the 5 GHz PMN survey. The total-power maps are now completed, and reduction of the polarisation data is still in progress. In addition to compact HII regions and extragalactic sources, we are detecting on our total-power images a considerable amount of large-scale structure, and a significant number of new SNR candidates and spur-like features.

We report on phase-referenced 5 and 8.4 GHz VLBI images of supernova SN 1993J in M81, tracking the evolution of the source from 50 to 1000 days after the explosion.

With new 6 cm observations we confirm the self-similar expansion of SN 1993J previously discovered at 3.6 cm and estimate the expansion deceleration parameter. The results are inconsistent with the existence of a constant pre-explosion stellar wind but otherwise confirm the standard radio supernova model. The first map at 13 cm showing shell structure is also presented.

The Lick Northern Proper Motion (NPM) and the Yale-San Juan Southern Proper Motion (SPM) programs have been described on several occasions (Wright 1950; Deutsch and Klemola 1974; Vasilevskis 1973; and Wesselink 1974). The two programs represent an attempt to measure the coordinates and proper motions, with respect to the extragalactic reference frames, for large numbers of stars representing most of the astrophysically-recognized classes. The photographic plate material forming the basis of the NPM program derives from the first (1947-1954) and second (1970-present) epoch phases for 1246 fields with the Lick 51 cm Carnegie double-astrograph for centers at -20° and northward (Shane and Wirtanen 1967). A southern supplement of 144 additional fields takes the program to -30°. The SPM consists of 632 fields with centers at -20° and southward. The first epoch plates were taken between 1965 and 1974 and a partial extension of 72 fields to more northerly declinations is essentially complete. One short and one long exposure permit the measurement of positions and approximate photometry for selected stars and reference galaxies over the blue magnitude range from about 8 to 17-18.

A high-resolution solar spectrum in the range 2000–2200 Å was obtained in a recent flight of a sunpointing Skylark rocket. This was launched at 04.21 hr UT on April 22, 1969 from Woomera and reached an apogee of 178 km. An optical alignment system operating on the main vehicle pointing system gave a net stabilisation of ±3 arc sec in the position of the solar image relative to the spectrograph slit. The slit, of length 1.0 mm, was set in the north-east quadrant parallel to and 5 arc min from the north/south axis, its lower edge being 1 arc min from the equator. The roll control of ±2.5° was provided entirely by the standard Elliott Bros. type of vehicle stabilisation.