We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure coreplatform@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
We prove that for any prime power $q\notin \{3,4,5\}$, the cubic extension $\mathbb {F}_{q^{3}}$ of the finite field $\mathbb {F}_{q}$ contains a primitive element $\xi $ such that $\xi +\xi ^{-1}$ is also primitive, and $\operatorname {\mathrm {Tr}}_{\mathbb {F}_{q^{3}}/\mathbb {F}_{q}}(\xi )=a$ for any prescribed $a\in \mathbb {F}_{q}$. This completes the proof of a conjecture of Gupta et al. [‘Primitive element pairs with one prescribed trace over a finite field’, Finite Fields Appl.54 (2018), 1–14] concerning the analogous problem over an extension of arbitrary degree $n\ge 3$.
On the U.S. Court of Appeals for the District of Columbia, then-Judge Ruth Bader Ginsburg authored an opinion with profound implications not only for the law of taxation but also for the role of courts in ending racial discrimination in education. The case, Wright v. Regan, involved the dramatic intersection of the income tax law and equal protection obligations of federal authorities under the Constitution’s Fifth and Fourteenth Amendments.
Hypotension is an adverse event that may be related to systemic exposure of milrinone; however, the true exposure–safety relationship is unknown.
Methods:
Using the Pediatric Trials Network multicentre repository, we identified children ≤17 years treated with milrinone. Hypotension was defined according to age, using the Pediatric Advanced Life Support guidelines. Clinically significant hypotension was defined as hypotension with concomitant lactate >3 mg/dl. A prior population pharmacokinetic model was used to simulate milrinone exposures to evaluate exposure–safety relationships.
Results:
We included 399 children with a median (quarter 1, quarter 3) age of 1 year (0,5) who received 428 intravenous doses of milrinone (median infusion rate 0.31 mcg/kg/min [0.29,0.5]). Median maximum plasma milrinone concentration was 110.7 ng/ml (48.4,206.2). Median lowest systolic and diastolic blood pressures were 74 mmHg (60,85) and 35 mmHg (25,42), respectively. At least 1 episode of hypotension occurred in 178 (45%) subjects; clinically significant hypotension occurred in 10 (2%). The maximum simulated milrinone plasma concentrations were higher in subjects with clinically significant hypotension (251 ng/ml [129,329]) versus with hypotension alone (86 ng/ml [44, 173]) versus without hypotension (122 ng/ml [57, 208], p = 0.002); however, this relationship was not retained on multivariable analysis (odds ratio 1.01; 95% confidence interval 0.998, 1.01).
Conclusions:
We successfully leveraged a population pharmacokinetic model and electronic health record data to evaluate the relationship between simulated plasma concentration of milrinone and systemic hypotension occurrence, respectively, supporting the broader applicability of our novel, efficient, and cost-effective study design for examining drug exposure–response and –safety relationships.
Substantial progress has been made in the standardization of nomenclature for paediatric and congenital cardiac care. In 1936, Maude Abbott published her Atlas of Congenital Cardiac Disease, which was the first formal attempt to classify congenital heart disease. The International Paediatric and Congenital Cardiac Code (IPCCC) is now utilized worldwide and has most recently become the paediatric and congenital cardiac component of the Eleventh Revision of the International Classification of Diseases (ICD-11). The most recent publication of the IPCCC was in 2017. This manuscript provides an updated 2021 version of the IPCCC.
The International Society for Nomenclature of Paediatric and Congenital Heart Disease (ISNPCHD), in collaboration with the World Health Organization (WHO), developed the paediatric and congenital cardiac nomenclature that is now within the eleventh version of the International Classification of Diseases (ICD-11). This unification of IPCCC and ICD-11 is the IPCCC ICD-11 Nomenclature and is the first time that the clinical nomenclature for paediatric and congenital cardiac care and the administrative nomenclature for paediatric and congenital cardiac care are harmonized. The resultant congenital cardiac component of ICD-11 was increased from 29 congenital cardiac codes in ICD-9 and 73 congenital cardiac codes in ICD-10 to 318 codes submitted by ISNPCHD through 2018 for incorporation into ICD-11. After these 318 terms were incorporated into ICD-11 in 2018, the WHO ICD-11 team added an additional 49 terms, some of which are acceptable legacy terms from ICD-10, while others provide greater granularity than the ISNPCHD thought was originally acceptable. Thus, the total number of paediatric and congenital cardiac terms in ICD-11 is 367. In this manuscript, we describe and review the terminology, hierarchy, and definitions of the IPCCC ICD-11 Nomenclature. This article, therefore, presents a global system of nomenclature for paediatric and congenital cardiac care that unifies clinical and administrative nomenclature.
The members of ISNPCHD realize that the nomenclature published in this manuscript will continue to evolve. The version of the IPCCC that was published in 2017 has evolved and changed, and it is now replaced by this 2021 version. In the future, ISNPCHD will again publish updated versions of IPCCC, as IPCCC continues to evolve.
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic is still ongoing along with the global vaccination efforts against it. Here, we aimed to understand the longevity and strength of anti-SARS-CoV-2 IgG responses in a small community (n = 283) six months following local SARS-COV-2 outbreak in March 2020. Three serological assays were compared and neutralisation capability was also determined. Overall 16.6% (47/283) of the participants were seropositive and 89.4% (42/47) of the IgG positives had neutralising antibodies. Most of the symptomatic individuals confirmed as polymerase chain reaction (PCR) positive during the outbreak were seropositive (30/32, 93.8%) and 33.3% of the individuals who quarantined with a PCR confirmed patient had antibodies. Serological assays comparison revealed that Architect (Abbott) targeting the N protein LIASON® (DiaSorin) targeting the S protein and enzyme-linked immunosorbent assay (ELISA) targeting receptor binding domain detected 9.5% (27/283), 17.3% (49/283) and 17% (48/283), respectively, as IgG positives. The latter two assays highly agreed (kappa = 0.89) between each other. In addition, 95%, (19/20, by ELISA) and 90.9% (20/22, with LIASON) and only 71.4% (15/21, by Architect) of individuals that were seropositive in May 2020 were found positive also in September. The unexpected low rate of overall immunity indicates the absence of un-noticed, asymptomatic infections. Lack of overall high correlation between the assays is attributed mainly to target-mediated antibody responses and suggests that using a single serological assay may be misleading.
This study aimed to investigate general factors associated with prognosis regardless of the type of treatment received, for adults with depression in primary care.
Methods
We searched Medline, Embase, PsycINFO and Cochrane Central (inception to 12/01/2020) for RCTs that included the most commonly used comprehensive measure of depressive and anxiety disorder symptoms and diagnoses, in primary care depression RCTs (the Revised Clinical Interview Schedule: CIS-R). Two-stage random-effects meta-analyses were conducted.
Results
Twelve (n = 6024) of thirteen eligible studies (n = 6175) provided individual patient data. There was a 31% (95%CI: 25 to 37) difference in depressive symptoms at 3–4 months per standard deviation increase in baseline depressive symptoms. Four additional factors: the duration of anxiety; duration of depression; comorbid panic disorder; and a history of antidepressant treatment were also independently associated with poorer prognosis. There was evidence that the difference in prognosis when these factors were combined could be of clinical importance. Adding these variables improved the amount of variance explained in 3–4 month depressive symptoms from 16% using depressive symptom severity alone to 27%. Risk of bias (assessed with QUIPS) was low in all studies and quality (assessed with GRADE) was high. Sensitivity analyses did not alter our conclusions.
Conclusions
When adults seek treatment for depression clinicians should routinely assess for the duration of anxiety, duration of depression, comorbid panic disorder, and a history of antidepressant treatment alongside depressive symptom severity. This could provide clinicians and patients with useful and desired information to elucidate prognosis and aid the clinical management of depression.
Let $r,n>1$ be integers and $q$ be any prime power $q$ such that $r\mid q^{n}-1$. We say that the extension $\mathbb{F}_{q^{n}}/\mathbb{F}_{q}$ possesses the line property for $r$-primitive elements property if, for every $\unicode[STIX]{x1D6FC},\unicode[STIX]{x1D703}\in \mathbb{F}_{q^{n}}^{\ast }$ such that $\mathbb{F}_{q^{n}}=\mathbb{F}_{q}(\unicode[STIX]{x1D703})$, there exists some $x\in \mathbb{F}_{q}$ such that $\unicode[STIX]{x1D6FC}(\unicode[STIX]{x1D703}+x)$ has multiplicative order $(q^{n}-1)/r$. We prove that, for sufficiently large prime powers $q$, $\mathbb{F}_{q^{n}}/\mathbb{F}_{q}$ possesses the line property for $r$-primitive elements. We also discuss the (weaker) translate property for extensions.
An internationally approved and globally used classification scheme for the diagnosis of CHD has long been sought. The International Paediatric and Congenital Cardiac Code (IPCCC), which was produced and has been maintained by the International Society for Nomenclature of Paediatric and Congenital Heart Disease (the International Nomenclature Society), is used widely, but has spawned many “short list” versions that differ in content depending on the user. Thus, efforts to have a uniform identification of patients with CHD using a single up-to-date and coordinated nomenclature system continue to be thwarted, even if a common nomenclature has been used as a basis for composing various “short lists”. In an attempt to solve this problem, the International Nomenclature Society has linked its efforts with those of the World Health Organization to obtain a globally accepted nomenclature tree for CHD within the 11th iteration of the International Classification of Diseases (ICD-11). The International Nomenclature Society has submitted a hierarchical nomenclature tree for CHD to the World Health Organization that is expected to serve increasingly as the “short list” for all communities interested in coding for congenital cardiology. This article reviews the history of the International Classification of Diseases and of the IPCCC, and outlines the process used in developing the ICD-11 congenital cardiac disease diagnostic list and the definitions for each term on the list. An overview of the content of the congenital heart anomaly section of the Foundation Component of ICD-11, published herein in its entirety, is also included. Future plans for the International Nomenclature Society include linking again with the World Health Organization to tackle procedural nomenclature as it relates to cardiac malformations. By doing so, the Society will continue its role in standardising nomenclature for CHD across the globe, thereby promoting research and better outcomes for fetuses, children, and adults with congenital heart anomalies.
Layer A in the Hayonim Cave in the western Galilee is an accumulation of ashes and dung caused by penned flocks since the 3rd century AD. A 2nd century AD glass furnace was found, dug into the Natufian deposits below (Layer B). Five Natufian occupation phases were characterized by a series of small rounds built from brought-in rocks. Burials including decorated individuals, a collection of incised limestone slabs and bone objects, rich assemblages of marine shells, bone pendants bone tools together with abundant lithics characterize the Natufian remains. At the entrance to the cave the Natufian dug into the Kebaran deposit (Layer C) and inside the cave into Aurignacian occupation (Layer D). Fortunately the later preserved a typical European-style lithic industry and an assemblage of bone and antler objects. The Late Mousterian, poorly represented, overlies rich occupations with lithic assemblages resembling Qafzeh cave. The latter cover with minimal interruptions a rich Early Mousterian deposit characterized by (many) retouched elongated blade blanks and points, (Layers E and F). Layer G, an Acheulo-Yabrudian, was tested in the deep sounding but bedrock was not attained.
Introduction: Common short screening measures of dependence that use number of cigarettes per day may not be appropriate for use in populations of occasional smokers.
Aims: In this study, we investigate whether perceived addiction (PA) predicts quit attempts and successful cessation among occasional smokers.
Methods: Current occasional smokers (18+) in the Ontario Tobacco Survey (OTS) longitudinal cohort study followed up every six months for up to three years. Respondents rated their self-perceived level of addiction (very vs. somewhat or not very addicted). Generalised Estimating Equation models and proportional hazard models were used to test the predictive ability of PA.
Results/Findings: Occasional smokers with very high PA had a higher likelihood of reporting a quit attempt (RR: 2.49; 95% CI: 1.88, 3.30) after adjusting for demographics. Given an incident quit attempt, occasional smokers who reported being very addicted were 2.93 times more likely to relapse (95%: 2.01, 4.28). The effect of PA was independent of other predictors of smoking behaviour.
Conclusions: For some, occasional smokers, smoking cessation is a difficult process that may require significant support. Asking occasional smokers about PA is an effective way to predict likely success in quitting smokers that may be easily assessed in population based, as well as in community and clinical, settings.
On the U.S. Court of Appeals for the District of Columbia, then-Judge Ruth Bader Ginsburg authored an opinion with profound implications not only for the law of taxation but also for the role of courts in ending racial discrimination in education. The case, Wright v. Regan, involved the dramatic intersection of the income tax law and equal protection obligations of federal authorities under the Constitution’s Fifth and Fourteenth Amendments. The precise technical legal issue before her was procedural – whether parents of black schoolchildren had standing to challenge the grant of federal tax-exempt status to racially segregated private schools – but it was hardly arcane or narrow. In affirming that standing existed and reversing the contrary decision of the District Court below, Judge Ginsburg opined that the tax benefits of exempt status constituted significant financial assistance and that the provision of such assistance to racially segregated private schools – so-called “seg academies” – violated equal protection obligations imposed by the Constitution.
Judge Ginsburg’s decision was unfortunately reversed on appeal by a divided Supreme Court, which ruled that the plaintiffs did not have standing because they lacked a sufficiently concrete interest in the outcome of the litigation. She nevertheless provided a persuasive and coherent defense of the right of victims of racial discrimination in education to seek redress in the courts, and strong dissents from Justices Brennan and Stevens (joined by Justice Blackmun) supported her position. She thus created a benchmark that future Supreme Courts may use to revise a Supreme Court majority decision that appears, at least to this observer, as fundamentally wrong and fundamentally flawed. Her opinion in Wright also offers ways of understanding the later development of educational equal protection doctrine, including Ginsburg’s seminal decision in the Virginia Military Institute case.
The terminal lake systems of central Australia are key sites for the reconstruction of late Quaternary paleoenvironments. Paleoshoreline deposits around these lakes reflect repeated lake filling episodes and such landforms have enabled the establishment of a luminescence-based chronology for filling events in previous studies. Here we present a detailed documentation of the morphology and chemistry of soils developed in four well-preserved beach ridges of late Pleistocene and mid-to-late Holocene age at Lake Callabonna to assess changes in dominant pedogenic processes. All soil profiles contain evidence for the incorporation of eolian-derived material, likely via the formation of desert pavements and vesicular horizons, and limited illuviation due to generally shallow wetting fronts. Even though soil properties in the four studied profiles also provide examples of parent material influence or site-specific processes related to the geomorphic setting, there is an overall trend of increasing enrichment of eolian-derived material since at least ~ 33 ka. Compared to the Holocene profiles, the derived average accumulation rates for the late Pleistocene profiles are significantly lower and may suggest that soils record important regional changes in paleoenvironments and dust dynamics related to shifts in the Southern Hemisphere westerlies.