We correlated antibiotic consumption measured by point prevalence survey with defined daily doses (DDD) across multiple hospitals. Point prevalence survey had a higher correlation (1) with monthly DDDs than annual DDDs, (2) in nonsurgical versus surgical wards, and (3) on high- versus low-utilization wards. Findings may be hospital specific due to hospital differences.

Patients with Parkinson’s disease psychosis (PDP) are often treated with an atypical antipsychotic, especially quetiapine or clozapine, but side effects, lack of sufficient efficacy, or both may motivate a switch to pimavanserin, the first medication approved for management of PDP. How best to implement a switch to pimavanserin has not been clear, as there are no controlled trials or case series in the literature to provide guidance. An abrupt switch may interrupt partially effective treatment or potentially trigger rebound effects from antipsychotic withdrawal, whereas cross-taper involves potential drug interactions. A panel of experts drew from published data, their experience treating PDP, lessons from switching antipsychotic drugs in other populations, and the pharmacology of the relevant drugs, to establish consensus recommendations. The panel concluded that patients with PDP can be safely and effectively switched from atypical antipsychotics used off label in PDP to the recently approved pimavanserin by considering each agent’s pharmacokinetics and pharmacodynamics, receptor interactions, and the clinical reason for switching (efficacy or adverse events). Final recommendations are that such a switch should aim to maintain adequate 5-HT2A antagonism during the switch, thus providing a stable transition so that efficacy is maintained. Specifically, the consensus recommendation is to add pimavanserin at the full recommended daily dose (34 mg) for 2–6 weeks in most patients before beginning to taper and discontinue quetiapine or clozapine over several days to weeks. Further details are provided for this recommendation, as well as for special clinical circumstances where switching may need to proceed more rapidly.

While social scientists have long advocated the use of statistical methodology in legal analysis, its practical application has not been tested. Statistical models based on social science theories have been used to predict judicial decisions and explain court behavior, but the legal profession has failed to develop statistical models based on traditional legal theories and using data familiar to the lawyer. This article seeks to demonstrate by practical application of statistical methodologies, coupled with traditional legal research methods, that such research can produce important insight into a court's decision making and provide a useful model for predicting the probability of a favorable decision. The zoning amendment decisions of the Connecticut Supreme Court are the data base of this study, which also provides a comprehensive explanation of zoning amendment law in Connecticut as a backdrop against which to evaluate the insights gained by statistical analysis.

Based on the data from the Next Generation Virgo cluster Survey (NGVS), we statistically study the photometric properties of globular clusters (GCs), ultra-compact dwarfs (UCDs) and dwarf nuclei in the Virgo core (M87) region. We found an obvious negative color (g - z) gradient in GC system associate with M87, i.e. GCs in the outer regions are bluer. However, such color gradient does not exist in UCD system, neither in dwarf nuclei system around M87. In addition, we found that many UCDs are surrounded by extended, low surface brightness envelopes. The dwarf nuclei and UCDs show different spatial distributions from GCs, with dwarf nuclei and UCDs (especially for the UCDs with visible envelopes) lying at larger distances to the Virgo center. These results support the view that UCDs (at least for a fraction of UCDs) are more tied to dwarf nuclei than to GCs.

The Neotoma Paleoecology Database is a community-curated data resource that supports interdisciplinary global change research by enabling broad-scale studies of taxon and community diversity, distributions, and dynamics during the large environmental changes of the past. By consolidating many kinds of data into a common repository, Neotoma lowers costs of paleodata management, makes paleoecological data openly available, and offers a high-quality, curated resource. Neotoma’s distributed scientific governance model is flexible and scalable, with many open pathways for participation by new members, data contributors, stewards, and research communities. The Neotoma data model supports, or can be extended to support, any kind of paleoecological or paleoenvironmental data from sedimentary archives. Data additions to Neotoma are growing and now include >3.8 million observations, >17,000 datasets, and >9200 sites. Dataset types currently include fossil pollen, vertebrates, diatoms, ostracodes, macroinvertebrates, plant macrofossils, insects, testate amoebae, geochronological data, and the recently added organic biomarkers, stable isotopes, and specimen-level data. Multiple avenues exist to obtain Neotoma data, including the Explorer map-based interface, an application programming interface, the neotoma R package, and digital object identifiers. As the volume and variety of scientific data grow, community-curated data resources such as Neotoma have become foundational infrastructure for big data science.

The Alphabet of Words (AW), a Latin alphabet text with an interlinear Old English gloss, occurs among the additions made to the Durham Collectar (D) by the priest Aldred in the tenth century. Previously thought to be extant only in D, and possibly by Aldred himself, AW also survives (without the OE gloss) in a Kassel manuscript (K) from the second half of the eighth century, as well as in a defective twelfth-century copy in Karlsruhe (Kr). Most of AW is also incorporated in a Latin treatise on the alphabet (“Audiuimus multos”: AM) compiled probably in the ninth century. AW belongs to the genre of “parenetic alphabet,” widely attested in Greek but also sporadically in Latin, including in a ninth-century Paris manuscript (P: BNF, lat. 2796) that shares lemmata and glosses with AW for the letters X, Y, and Z. We provide the first critical edition and translation of AW from D, K, and Kr, with variants from AM and P, together with a discussion of AW’s genre and relation to other alphabetical texts as well as a full commentary on the biblical, apocryphal, and patristic lore transmitted by AW’s lemmata and glosses on each letter.

Ten ice-sheet models are used to study sensitivity of the Greenland and Antarctic ice sheets to prescribed changes of surface mass balance, sub-ice-shelf melting and basal sliding. Results exhibit a large range in projected contributions to sea-level change. In most cases, the ice volume above flotation lost is linearly dependent on the strength of the forcing. Combinations of forcings can be closely approximated by linearly summing the contributions from single forcing experiments, suggesting that nonlinear feedbacks are modest. Our models indicate that Greenland is more sensitive than Antarctica to likely atmospheric changes in temperature and precipitation, while Antarctica is more sensitive to increased ice-shelf basal melting. An experiment approximating the Intergovernmental Panel on Climate Change’s RCP8.5 scenario produces additional first-century contributions to sea level of 22.3 and 8.1 cm from Greenland and Antarctica, respectively, with a range among models of 62 and 14 cm, respectively. By 200 years, projections increase to 53.2 and 26.7 cm, respectively, with ranges of 79 and 43 cm. Linear interpolation of the sensitivity results closely approximates these projections, revealing the relative contributions of the individual forcings on the combined volume change and suggesting that total ice-sheet response to complicated forcings over 200 years can be linearized.

Early in the history of schistosomiasis research, children under 5 years of age were known to be infected. Although this problem was recognized over 100 years ago, insufficient action has been taken to address this issue. Under current policy, such infected children only receive their first antiparasitic treatment (praziquantel – PZQ) upon entry into primary school as current mass drug administration programmes typically target school-aged children. For many infected children, they will wait up to 6 years before receiving their first medication and significant schistosomiasis-related morbidity may have already established. This inequity would not be accepted for other diseases. To unveil some of the reasons behind this neglect, it is paramount to understand the intricate historical relationship between schistosomiasis and British Imperial medicine, to underline its lasting influence on today's public health priorities. This review presents a perspective on the historical neglect of paediatric schistosomiasis, focusing on important gaps that persist from the early days after discovery of this parasite. Looking to end this inequity, we address several issues that need to be overcome to move forward towards the lasting success of schistosomiasis control and elimination efforts.

We present data produced through archaeological and geological survey, as well as geochemical analysis of the Zaragoza-Oyameles obsidian source area located on the northern and western flanks of the Los Humeros Caldera in eastern Puebla, Mexico. One result of the intensive archaeological surface survey of this obsidian source area was the identification of 117 obsidian flow-band exposures. Geologic samples from 40 of these were submitted for instrumental neutron activation analysis. Eighty-five projectile points collected from the surface were characterized using portable X-ray fluorescence. These analyses identified three sub-sources: Z-O1, Potreros Caldera, and Gomez Sur. The Gomez Sur sub-source appears chemically similar to the previously identified Altotonga source, located 25 km to the northeast. Results of the geological survey help elucidate the relationship of Altotonga obsidian with the Zaragoza-Oyameles source area. The data from the three sub-sources are compared to all consumer site data attributed to the Zaragoza-Oyameles source in the Missouri University Research Reactor database. Results indicate that the majority of consumer samples throughout Mesoamerica match the Z-O1 sub-source, while 4 percent match the Potreros Caldera sub-source. This information, combined with the Gomez Sur data, is discussed in terms of economic relations with the regional center of Cantona. Obsidian procurement and distribution may have been more nuanced than previously modeled. We suggest that a number of potentially independent communities in addition to Cantona may have been involved in distributing this obsidian throughout Mesoamerica.

The accurate and precise collection of three-dimensional (3D) context and provenience data is of critical importance for archaeologists. Traditional square-hole methods are being augmented by new digital techniques to increase the accuracy and precision with which 3D data are collected. Structure from Motion (SfM) photogrammetry is an emerging digital technique that is becoming more widespread for collecting 3D data of archaeological sites and features. We are using handheld digital cameras and ground-based SfM to record accurate and precise 3D context and provenience data at the scale of the excavation unit and profile during rockshelter excavations in the Lower Pecos Canyonlands of Texas. By combining SfM with traditional excavation methods, we collect 3D data on excavation units, layers, features, and profiles without excavating in grid-bound square units. SfM provides a straightforward and flexible method to excavate based on the stratigraphy and logistical pragmatics, which further aids in assigning precise context and provenience to recovered artifacts and samples. This article describes how ground-based SfM serves as a basic recording tool during excavation and shows that, by applying ground-based SfM methods to excavation, archaeologists can collect more, and more accurate, data than with traditional square-hole methods.

Wire strain meters and seismometers spaced longitudinally along the upper part of Variegated Glacier, Alaska, showed quasi-periodic episodes of increased velocity (mini-surges), which lasted about 1 day and recurred at intervals of a few days to 2 weeks during the early part of the melt seasons of 1979, 1980, and 1981. The zone affected by these mini-surges corresponds to the zone of highest velocity and basal stress increase over the previous decade, and the initiation of the most recent surge in 1982. Mini-surges initiate locally; as a single melt season progresses, the later mini-surges start at higher locations and show a distinct down-glacier propagation of a characteristic strain pattern and associated zone of acoustic emissions at speeds of 0.1–0.6 km h−1. During mini-surges, extensile and compressive strain-rates exceed 10 × 10−4 d−1 and 40 × 10−4 d−1, respectively; typical strain-rates between mini-surges were less than 2 × 10−4d−1 in magnitude. Seismic activity jumped by two orders of magnitude and was distinctly audible during a mini-surge. Maximum strain-rate during mini-surges decreased from year to year. The high time resolution of the strain allows short time-scale structure of velocity variations to be deduced. As a propagating mini-surge passes, the velocity anomaly at a fixed location is characterized by a rapid initial rise over a few hours to two distinct peaks separated by a few hours, followed by a slower return to normal velocity taking up to a day. The double peak in velocity may arise from a single, very sharp, transient peak in the basal slip velocity associated with the initial opening of cavities at the base in response to a sudden rise in basal water pressure (observed by Kamb and Engelhardt). This supports an important role for basal cavitation in the mini-surge mechanism.