Field experiments were conducted in 1989 and 1990 on silty clay and sandy loam soils to evaluate weed control and soybean yield with early-April preplant incorporation of selective herbicides in stale seedbed soybean followed by non-selective weed control measures at planting. Metribuzin applied PPI early followed by chlorimuron POST coupled with either glyphosate or paraquat PRE controlled sicklepod, pitted morningglory, and hemp sesbania to the same extent of that treatment applied PPI at planting. All stale seedbed treatments with POST applications and glyphosate, paraquat, or tillage at planting controlled pitted morningglory over 70%. However, imazaquin or metribuzin applied PPI early without a POST treatment controlled sicklepod and pitted morningglory poorly. Frequently, applying PPI herbicides at planting increased control compared with early PPI applications, but this was overcome by POST treatments. Early stale seedbed applications of metribuzin did not result in more than 60% control of hemp sesbania, whereas metribuzin applied PPI at planting controlled over 85%. However, metribuzin plus chlorimuron controlled hemp sesbania at least 74%, regardless of application timing or tillage method, whereas no imazaquin treatment achieved over 65% control. All stale seedbed herbicide treatments increased soybean yield compared with the untreated stale seedbed check. Selective herbicide treatments with either non-selective herbicide in a stale seedbed program resulted in equivalent yield to PPI at planting treatments most often, except with metribuzin.