In this paper we give an answer to Furstenberg’s problem on topological disjointness. Namely, we show that a transitive system $(X,T)$ is disjoint from all minimal systems if and only if $(X,T)$ is weakly mixing and there is some countable dense subset $D$ of $X$ such that for any minimal system $(Y,S)$ , any point $y\in Y$ and any open neighbourhood $V$ of $y$ , and for any non-empty open subset $U\subset X$ , there is $x\in D\cap U$ such that $\{n\in \mathbb{Z}_{+}:T^{n}x\in U,S^{n}y\in V\}$ is syndetic. Some characterization for the general case is also given. By way of application we show that if a transitive system $(X,T)$ is disjoint from all minimal systems, then so are $(X^{n},T^{(n)})$ and $(X,T^{n})$ for any $n\in \mathbb{N}$ . It turns out that a transitive system $(X,T)$ is disjoint from all minimal systems if and only if the hyperspace system $(K(X),T_{K})$ is disjoint from all minimal systems.

In this research communication we used digital gene expression (DGE) analysis to identify differences in gene expression in the mammary glands of dairy cows between early lactation and the mid-dry period. A total of 741 genes were identified as being differentially expressed by DGE analysis. Compared with their expression in dry cows, 214 genes were up-regulated and 527 genes were down-regulated in lactating cow mammary glands. Gene Ontology analysis showed that lactation was supported by increased gene expression related to metabolic processes and nutrient transport and was associated with decreased gene expression related to cell proliferation. Pathway mapping using the Kyoto Encyclopedia of Genes and Genomes showed that 579 differentially expressed genes had pathway annotations related to 204 pathways. Metabolic pathway-related genes were the most significantly enriched. Genes and pathways identified by the present study provide insights into molecular events that occur in the mammary gland between early lactation and mid-dry period, which can be used to facilitate further investigation of the mechanisms underlying lactation and mammary tissue remodeling in dairy cows.

To optimise patients’ outcomes and gain insight into transmitted drug resistance (TDR) among human immunodeficiency virus (HIV)-1 treatment-naive patients in Beijing, the prevalence of TDR was assessed. Demographic and clinical data of 1241 treatment-naive patients diagnosed between April 2014 and February 2015 were collected. TDR was defined using the Stanford University HIV drug resistance mutations database. The risk factors were evaluated by multi-logistic regression analysis. Among 932 successfully amplified cases, most were male (96.78%) and infected through men having sex with men (91.74%). Genotype were CRF01_AE (56.44%), B (20.60%), CRF07_BC (19.96%), C (1.61%) and other genotypes (1.39%). The overall prevalence of TDR was 6.12%. Most frequent mutations occurred in non-nucleoside reverse transcriptase inhibitors (NNRTIs) (3.11%), followed by protease inhibitors (PIs) (2.25%) and nucleoside reverse transcriptase inhibitors (NRTIs) (1.32%). Furthermore, HIV-1 genotype was associated with high risk of resistance, in which genotype C and other genotype may have higher risk for resistance. The prevalence among treatment-naive patients in Beijing was low. Resistance to NNRTIs was higher than with PIs or NRTIs. Continuous monitoring of regional levels of HIV-1 TDRs would contribute to improve treatment outcomes and prevent failures.

In this paper, we experimentally investigated the extreme frequency shift in high-power Raman fiber laser (RFL). The RFL was developed by using a pair of fiber Bragg gratings with fixed and matched central wavelength (1120 nm) combined with a piece of 31-m-long polarization maintaining (PM) passive fiber adopted as Raman gain medium. The pump source was a homemade high-power, linearly polarized (LP) wavelength-tunable master oscillator power amplifier (MOPA) source with ${\sim}25~\text{nm}$ tunable working range (1055–1080 nm). High-power and high-efficiency RFL with extreme frequency shift between the pump and Stokes light was explored. It is found that frequency shift located within 10.6 THz and 15.2 THz can ensure efficient Raman lasing, where the conversion efficiency is more than 95% of the maximal value, 71.3%. In addition, a maximum output power of 147.1 W was obtained with an optical efficiency of 71.3%, which is the highest power ever reported in LP RFLs to the best of our knowledge.

Hepatitis C virus (HCV) infection is one of the leading causes of death and morbidity associated with liver disease. Risk factors identified for the transmission of HCV include contaminated blood products, intravenous drug use, body piercing, an infected mother at birth, sexual activity, and dental therapy, among others. However, the exact diversity of the HCV genotype and genetic variation among patients with low-risk factors is still unknown. In this study, we briefly described and analysed the genotype distribution and genetic variation of HCV infections with low-risk factors using molecular biology techniques. The results suggested that genotype 1b was predominant, followed by genotypes 2a and 1a. Genetic variations in the 5′ UTR sequences of HCV were identified, including point mutations, deletions, and insertions. The frequency of genetic variations in 1b was higher than in 2a. This study provides considerable value for the prevention and treatment of liver disease caused by HCV among patients with low-risk factors and for the development of HCV diagnostic reagents and vaccines.

Glacier area changes on the Tibetan Plateau were studied in different drainage basins based on Landsat satellite images from three epochs: 263 in the mid-1970s, 150 in 1999–2002 and 148 in 2013/14. Three mosaics (M1976, M2001 and M2013) with minimal cloud and snow cover were constructed, and the uncertainty due to each epoch having a finite span was accounted for. Glacier outlines (TPG1976, TPG2001 and TPG2013) were digitized manually with guidance from the SRTM DEM v4.1 and Google Earth imagery. To achieve complete multi-temporal coverage in a reasonable time, only debris-free ice was delineated. Area mapping uncertainty was evaluated at three study sites, Mount Qomolangma (Everest), Mount Naimona'Nyi, Mount Geladandong, where the largest differences between present and earlier measurements were within ~±4%. Area differences with previous inventories ranged from −19.6% (TPG1976 minus the first Chinese Glacier Inventory) to −3.6% and −1.1% (TPG2013 and TPG2001, respectively minus the second Chinese Glacier Inventory), while the difference TPG2001 minus the GAMDAM Glacier Inventory was +10.4%. Glacier area on the plateau decreased from 44 366 ± 2827 km2 (1.7% of the study area) in the 1970s to 42 210 ± 1621 km2 in 2001 and 41 137 ± 1616 km2 in 2013. Shrinkage was faster in external drainage basins of the southeast than in the interior basins of the northwest, from a maximum of −0.43% a−1 (−1.60% a−1 during 1994–2013) in the Mekong catchment down to a minimum of −0.12% a−1 in the Tarim interior drainage.

The effect of electropulsing assisted ultrasonic surface modification (EUSM) on microstructure and surface properties of S50C steel welded components is investigated. Compared with conventional ultrasonic surface modification (USM) process, EUSM process achieves significant improvements in microstructure, including deeper strengthened layers and gradient microstructure on the surface. The EUSM-induced microstructure results in higher levels of surface compressive residual stress and greater surface microhardness and its effective depth. Conventional USM process is inevitably accompanied by some plastic damages, such as pit and crack defects. The damages, however, can be eliminated to some extent during the EUSM process. These enhancements may be attributed to the thermal and athermal effects caused by electropulsing treatment, which accelerates the mobility of dislocations in the dynamic recrystallization process.

The morphology, chemistry and phylogenetic relationships of Chinese populations of Bulbothrix are described. Nine species, including two new species B. mammillaria Y. Y. Zhang & Li S. Wang sp. nov. and B. lacinia Y. Y. Zhang & Li S. Wang sp. nov., and two newly recorded for the flora, B. scortella and B. meizospora, are reported. Bulbothrix mammillaria can be recognized by the sparse cilia that are reduced to a bulbate structure and the broad lobes (3–11 mm). Bulbothrix lacinia differs from other species of the genus by dark brown, spherical to short-cylindrical isidia and common lacinulae on the upper surface. Phylogenetic relationships of currently known ITS sequences from Bulbothrix were inferred to assess the affinities of the new species. A key to all known species from China is presented.

The development of synthetic scaffolds with a desirable combination of properties, such as bioactivity, the ability to locally deliver antibacterial agents and high osteogenic capacity, is a challenging but promising approach in bone tissue engineering. In this study, scaffolds of a borosilicate bioactive glass (composition: 6Na2O, 8K2O, 8MgO, 22CaO, 36B2O3, 18SiO2, 2P2O5; mol%) with controllable antibacterial activity were developed by doping the parent glass with varying amounts of Ag2O (0.05, 0.5, and 1.0 wt%). The addition of the Ag2O lowered the compressive strength and degradation of the bioactive glass scaffolds but it did not affect the formation of hydroxyapatite on the surface of the glass as determined by energy dispersive x-ray analysis, x-ray diffraction, and Fourier transform infrared analysis. The Ag2O-doped scaffolds showed a sustained release of Ag ions over more than 8 weeks in simulated body fluid and resistance against colonization by the bacterial strains Escherichia coli and Staphylococcus aureus. In vitro cell culture showed better adhesion, proliferation, and alkaline phosphatase activity of murine osteoblastic MC3T3-E1 cells on the Ag2O-doped bioactive glass scaffolds than on the undoped scaffolds. The results indicate that these Ag-doped borosilicate bioactive glass scaffolds may have potential in repairing bone coupled with providing a lower risk of bacterial infection.

Electropulsing treatment (EPT) provided a promising technology to improve the microstructure and plasticity of the cold-rolled Ti–6Al–4V noticeably while only affecting the strength mildly. Thus, titanium alloy of high plasticity and good comprehensive property can be obtained by this high efficient processing method. The research found that the tensile ductility could be improved largely with the increasing frequency. In the low frequency, the maximum ductility (32.5%) could be obtained at 293 Hz-EPT. Under high-frequency EPT, plasticity has a slight decrease but the tensile strength increases in the contrary. With the help of multi-characterization, abstracting phenomena are explained and therefore the conclusion has been drawn that the whole process of increasing frequency EPT can be divided roughly into two periods: (a) recrystallization period in the low frequency, at this period athermal effect of the EPT played a leading role and (b) phase change period in the high frequency, at this period the other important factor of the EPT thermal effect was predominant. As a comparison, furnace heat treatment is conducted to prove the preferential phase transition instead of complete recrystallization under the single heating effect. The mechanism of the results can be discussed by the competitive mechanism of recrystallization process and phase change in the EPT processing.

The self-assembly of α,ω-dihexylsexithiophene molecules on an Au(111) surface was examined by using scanning tunneling microscopy at room temperature, revealing the internal molecular structures of the sexithiophene backbones and the hexyl side chains. The α,ω-dihexylsexithiophene formed a large and well-ordered monolayer in which the molecule lay flatly on the Au(111) surface and was separated into two chiral domains. A detailed observation reveals that the admolecules were packed in one lamellae with their molecular axis aligned along the main axis of the Au(111) substrate with their hexyl chains deviated from ⟨110⟩ direction of the Au(111) substrate by 12 ± 0.5°. In contrast to the behavior in the three-dimensional bulk structure, flat-lying adsorption introduced molecular chirality: right- and left-handed molecules separate into domains of two different orientations, which are mirror symmetric with respect to the ⟨121⟩ direction of the Au(111) substrate. Details of the adlayer structure and the chiral self-assembly were discussed here.

Self-assembled nanostructures of α,ω-dihexylsexithiophene (DH6T) formed by spreading DH6T solutions onto freshly cleaved mica surface were studied by atomic force microscopy. The effects of solvent and concentration on the nanostructures of DH6T molecules were studied. Flat, well-ordered, and platelet-like domains were observed on mica surfaces after treatment with various polar solvent solutions of DH6T. These domains form a uniform film with height of 2.4 ± 0.2 nm, which is consistent with a 45° tilt in the molecular conformation of DH6T on mica surfaces. The formation mechanism of these multilayers is discussed in detail.

The incidence and severity of Clostridium difficile infections (CDI) have increased in Western countries. However, there are limited data regarding the epidemiology of CDI in Eastern countries. This nationwide study was conducted in 17 hospitals to determine temporal trends in CDI incidence (from 2004 to 2008) in South Korea. The total incidence of CDI in Korea was 1·7 cases/1000 adult admissions in 2004, and 2·7/1000 cases in 2008 (P = 0·028). When analysing the clinical features of 1367 CDI patients diagnosed in 2008, oral metronidazole was effective as a first-line treatment for CDI (61·9%). Relapse rate was 8·9% and complicated CDI was only observed in 3·6%. The incidence of CDI increased significantly in Korea from 2004 to 2008. Although the clinical features were milder than in Western countries, the increasing burden of CDI needs ongoing surveillance systems.

An ∞-step nilsystem is an inverse limit of minimal nilsystems. In this article, it is shown that a minimal distal system is an ∞-step nilsystem if and only if it has no non-trivial pairs with arbitrarily long finite IP-independence sets. Moreover, it is proved that any minimal system without non-trivial pairs with arbitrarily long finite IP-independence sets is an almost one-to-one extension of its maximal ∞-step nilfactor, and each invariant ergodic measure is isomorphic (in the measurable sense) to the Haar measure on some ∞-step nilsystem. The question if such a system is uniquely ergodic remains open. In addition, the topological complexity of an ∞-step nilsystem is computed, showing that it is polynomial for each non-trivial open cover.

The initial stage of oxidation of Ti45Al7Nb0.4Y alloy (at.%) oxidized at 900 °C in air was investigated by using x-ray photoelectron spectroscopy and Auger electron spectroscopy. Experimental results revealed that YAl2 segregated along the grain boundaries preferentially oxidized to Y2O3 and Al2O3 due to strong affinity of Y to oxygen. Oxides grew faster at the grain boundaries than in lamellar colonies. As a result, Y and Al oxides pegs protruded into the substrate, which can increase the contact areas of oxide scale and substrate. Moreover, inward diffusion of oxygen more easily occurred along the grain boundaries. As a result, it promoted the external oxidation of Al within the grains due to lower inward diffusion flux of oxygen. And coarse-grained Y2O3 blocked the cationic intergranular diffusion. Therefore, Y addition can effectively enhance the Al2O3 layer and suppress the TiO2 outermost layer.

Cr3+-doped LiInSiO4 phosphors were prepared by a solid-state reaction method. X-ray diffraction measurement was carried out for crystalline phase identification. Absorption, photoluminescence, excitation, and time-resolved spectra were measured to investigate the optical properties of the phosphors. Two broadband near-infrared emissions centered at 920 and 1172 nm were observed. Time-resolved spectra show that the emission at 1172 nm decays more quickly than the emission at 920 nm. The electron spin resonance spectra exhibit a broad resonance signal at g = 1.96 because of exchange-coupled Cr3+ pairs. The value of Dq/B for low and intermediate crystal fields was evaluated. We suggest that Cr3+ incorporated into different octahedral sites of the crystal is responsible for the different near-infrared luminescence.

Cr3+/Ni2+ co-doped optically transparent magnesium aluminosilicate glass-ceramics containing MgAl2O4 nanocrystals have been prepared by heat-treatment. Greatly enhanced broadband near-infrared emission centered at 1216 nm in Cr3+/Ni2+ co-doped glass ceramics is observed when compared with the Ni2+ single-doped glass ceramics under 532 nm excitation. The observed enhancement of infrared emission is attributed to the energy transfer from Cr3+ to Ni2+ ions in the nanocrystalline phase, which leads to the emission due to 3T2(3F) → 3A2(3F) transition of octahedral Ni2+ ions.