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The oxidation behavior of the selective laser melting (SLM)–fabricated Inconel 718 was investigated through isothermal oxidation testing at 650 °C for 500 h and compared with that of the as-cast and as-forged specimens at the same testing conditions. The effect of microstructure and surface roughness on the oxidation behavior of the SLM-fabricated, as-cast, and as-forged Inconel 718 specimens was examined. The result shows that Inconel 718 fabricated by SLM with the unique layer structure exhibited a better resistance to the 500 h oxidation at 650 °C compared with as-cast and as-forged 718 with coarse dendritic structure and uniform equiaxed grain microstructure, respectively. The influence of the surface roughness on the long-time oxidation resistance of SLM specimens is not pronounced compared with that of as-cast and as-forged specimens. The tiny dendrites instead of grain boundaries are a major influencing factor for the oxidation process of SLM specimens. The surface roughness has more evident influence on the oxidation resistance of as-forged specimens than that of the as-cast ones subjected to the 500 h oxidation at 650 °C.
Schizophrenia is a common major mental disorder and prenatal nutritional deficiency may increase its risk. We aimed to investigate long-term impact of prenatal exposure to malnutrition on risk of schizophrenia in adulthood using the Chinese famine of 1959–1961 as a natural experiment.
We obtained data from the Second National Sample Survey on Disability implemented in 31 provinces in 2006, and restricted our analysis to 387,093 individuals born from 1956 to 1965. Schizophrenia was ascertained by psychiatrists based on the International Statistical Classification of Diseases, Tenth Revision. Famine severity was defined as cohort size shrinkage index. The famine effect on adult schizophrenia was estimated by difference-in-difference models, established by examining the variations of famine exposure across birth cohorts.
Compared with the reference cohort of 1965, famine cohorts (1959–1962) had significantly higher odds (OR: 1.84; 95% CI: 1.13, 3.00; P = 0.014) of schizophrenia in the rural population. After adjusting for multiple covariates, this association remained significant (OR: 1.82; 95% CI: 1.11, 2.98; P = 0.018). We did not observe statistically significant differences in odds of schizophrenia among famine cohorts compared with the reference cohort in the urban population.
Prenatal malnutrition exposure has a detrimental impact on risk of schizophrenia in adulthood in the rural population. Further studies were needed to investigate corresponding mechanisms on this topic.
The effects of flow topology on the subgrid-scale (SGS) kinetic energy flux in compressible isotropic turbulence is studied. The eight flow topological types based on the three invariants of the filtered velocity gradient tensor are analysed at different scales, along with their roles in the magnitude and direction of kinetic energy transfer. The unstable focus/compressing (UFC), unstable node/saddle/saddle (UN/S/S) and stable focus/stretching (SFS), are the three predominant topological types at all scales; they account for at least 75 % of the flow domain. The UN/S/S and SFS types make major contributions to the average SGS flux of the kinetic energy from large scales to small scales in the inertial range. The unstable focus/stretching (UFS) topology makes a contribution to the reverse SGS flux of kinetic energy from small scales to large scales. In strong compression regions, the average contribution of the stable node/saddle/saddle (SN/S/S) topology to the SGS kinetic energy flux is positive and is predominant over those of other flow topologies. In strong expansion regions, the UFS topology makes a major contribution to the reverse SGS flux of the kinetic energy. As the turbulent Mach number increases, the increase of volume fraction of the UFS topological regions leads to the increase of the SGS backscatter of kinetic energy. The SN/S/S topology makes a dominant contribution to the direct SGS flux of the compressible component of the kinetic energy, while the UFS topology makes a dominant contribution to the reverse SGS flux of the compressible component of the kinetic energy.
Schizophrenia is a complex mental disorder with high heritability and polygenic inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of brain structure and function are a plausible neurobiological characterisation of schizophrenia. However, the polygenic effects of schizophrenia on these imaging endophenotypes have not yet been fully elucidated.
To investigate the effects of polygenic risk for schizophrenia on the brain grey matter volume and functional connectivity, which are disrupted in schizophrenia.
Genomic and neuroimaging data from a large sample of Han Chinese patients with schizophrenia (N = 509) and healthy controls (N = 502) were included in this study. We examined grey matter volume and functional connectivity via structural and functional magnetic resonance imaging, respectively. Using the data from a recent meta-analysis of a genome-wide association study that comprised a large number of Chinese people, we calculated a polygenic risk score (PGRS) for each participant.
The imaging genetic analysis revealed that the individual PGRS showed a significantly negative correlation with the hippocampal grey matter volume and hippocampus–medial prefrontal cortex functional connectivity, both of which were lower in the people with schizophrenia than in the controls. We also found that the observed neuroimaging measures showed weak but similar changes in unaffected first-degree relatives of patients with schizophrenia.
These findings suggested that genetically influenced brain grey matter volume and functional connectivity may provide important clues for understanding the pathological mechanisms of schizophrenia and for the early diagnosis of schizophrenia.
Maternal exposure to major stressors during pregnancy has been found to increase the risk of neurodevelopmental, cognitive and psychiatric disorders in the offspring. However, the association between prenatal exposure to earthquake and the risk of adult schizophrenia has yet to be examined.
To explore the potential long-term effects of prenatal exposure to maternal stress on the risk of schizophrenia in adulthood, using the Great Tangshan Earthquake in 1976 as a natural experiment.
We obtained data from the Second China National Sample Survey on Disability, and analysed 94 410 Chinese individuals born between 1975 and 1979. We obtained difference-in-differences estimates of the earthquake effects on schizophrenia by exploiting temporal variation in the timing of earthquake exposure across four birth cohorts born between 1975 and 1979, along with geographical variation in earthquake severity at the prefecture level. Schizophrenia was ascertained by psychiatrists using the ICD-10 classification. Earthquake severity was measured by seismic intensity.
Earthquake cohort who experienced prenatal exposure to felt earthquake had higher risk of schizophrenia (odds ratio, 3.38; 95% CI 1.43–8.00) compared with the unexposed reference cohort. After specifying the timing of exposure by the trimester of pregnancy, prenatal exposure to felt earthquake during the first trimester of pregnancy increased the risk of adulthood schizophrenia significantly (odds ratio, 7.45; 95% CI 2.83–19.59).
Prenatal (particularly early pregnancy) exposure to maternal stress after a major disaster substantially affects the mental health of Chinese adults.
Cascades of temperature and entropy fluctuations are studied by numerical simulations of stationary three-dimensional compressible turbulence with a heat source. The fluctuation spectra of velocity, compressible velocity component, density and pressure exhibit the
scaling in an inertial range. The strong acoustic equilibrium relation between spectra of the compressible velocity component and pressure is observed. The
scaling behaviour is also identified for the fluctuation spectra of temperature and entropy, with the Obukhov–Corrsin constants close to that of a passive scalar spectrum. It is shown by Kovasznay decomposition that the dynamics of the temperature field is dominated by the entropic mode. The average subgrid-scale (SGS) fluxes of temperature and entropy normalized by the total dissipation rates are close to 1 in the inertial range. The cascade of temperature is dominated by the compressible mode of the velocity field, indicating that the theory of a passive scalar in incompressible turbulence is not suitable to describe the inter-scale transfer of temperature in compressible turbulence. In contrast, the cascade of entropy is dominated by the solenoidal mode of the velocity field. The different behaviours of cascades of temperature and entropy are partly explained by the geometrical properties of SGS fluxes. Moreover, the different effects of local compressibility on the SGS fluxes of temperature and entropy are investigated by conditional averaging with respect to the filtered dilatation, demonstrating that the effect of compressibility on the cascade of temperature is much stronger than on the cascade of entropy.
A 5G new radio cellular system is characterized by three main usage scenarios of enhanced mobile broadband (eMBB), ultra-reliable and low latency communications (URLLC), and massive machine type communications, which require improved throughput, latency, and reliability compared with a 4G system. This overview paper discusses key characteristics of 5G channel coding schemes which are mainly designed for the eMBB scenario as well as for partial support of the URLLC scenario focusing on low latency. Two capacity-achieving channel coding schemes of low-density parity-check (LDPC) codes and polar codes have been adopted for 5G where the former is for user data and the latter is for control information. As a coding scheme for data, 5G LDPC codes are designed to support high throughput, a variable code rate and length and hybrid automatic repeat request in addition to good error correcting capability. 5G polar codes, as a coding scheme for control, are designed to perform well with short block length while addressing a latency issue of successive cancellation decoding.
True ileal digestibility (TID) values of amino acid (AA) obtained using growing rats are often used for the characterisation of protein quality in different foods and acquisition of digestible indispensable amino acid scores (DIAAS) in adult humans. Here, we conducted an experiment to determine the TID values of AA obtained from nine cooked cereal grains (brown rice, polished rice, buckwheat, oats, proso millet, foxtail millet, tartary buckwheat, adlay and whole wheat) fed to growing Sprague–Dawley male rats. All rats were fed a standard basal diet for 7 d and then received each diet for 7 d. Ileal contents were collected from the terminal 20 cm of ileum. Among the TID values obtained, whole wheat had the highest values (P<0·05), and polished rice, proso millet and tartary buckwheat had relatively low values. The TID indispensable AA concentrations in whole wheat were greater than those of brown rice or polished rice (P<0·05), and polished rice was the lowest total TID concentrations among the other cereal grains. The DIAAS was 68 for buckwheat, 47 for tartary buckwheat, 43 for oats, 42 for brown rice, 37 for polished rice, 20 for whole wheat, 13 for adlay, 10 for foxtail millet and 7 for proso millet. In this study, the TID values of the nine cooked cereal grains commonly consumed in China were used for the creation of a DIAAS database and thus gained public health outcomes.
We study the numerical Adomian decomposition method for the pricing of European options under the well-known Black–Scholes model. However, because of the nondifferentiability of the pay-off function for such options, applying the Adomian decomposition method to the Black–Scholes model is not straightforward. Previous works on this assume that the pay-off function is differentiable or is approximated by a continuous estimation. Upon showing that these approximations lead to incorrect results, we provide a proper approach, in which the singular point is relocated to infinity through a coordinate transformation. Further, we show that our technique can be extended to pricing digital options and European options under the Vasicek interest rate model, in both of which the pay-off functions are singular. Numerical results show that our approach overcomes the difficulty of directly dealing with the singularity within the Adomian decomposition method and gives very accurate results.
While a classic result by Merton (1973, Bell J. Econ. Manage. Sci., 141–183) is that one should never exercise an American call option just before expiration if the underlying stock pays no dividends, the conclusion of a very recent empirical study conducted by Jensen and Pedersen (2016, J. Financ. Econ.121(2), 278–299) suggests that one should ‘never say never’. This paper complements Jensen and Pedersen's empirical study by presenting a theoretical study on how to price American call options under a hard-to-borrow stock model proposed by Avellaneda and Lipkin (2009, Risk22(6), 92–97). Our study confirms that it is the lending fee that results in the early exercise of American call options and we shall also demonstrate to what extent lending fees have affected the early exercise decision.
Kawasaki disease, which is characterised by systemic vasculitides accompanied by acute fever, is regularly treated by intravenous immunoglobulin to avoid lesion formation in the coronary artery; however, the mechanism of intravenous immunoglobulin therapy is unclear. Hence, we aimed to analyse the global expression profile of serum exosomal proteins before and after administering intravenous immunoglobulin.
Two-dimensional electrophoresis coupled with mass spectrometry analysis was used to identify the differentially expressed proteome of serum exosomes in patients with Kawasaki disease before and after intravenous immunoglobulin therapy.
Our analysis revealed 69 differential protein spots in the Kawasaki disease group with changes larger than 1.5-fold and 59 differential ones in patients after intravenous immunoglobulin therapy compared with the control group. Gene ontology analysis revealed that the acute-phase response disappeared, the functions of the complement system and innate immune response were enhanced, and the antibacterial humoral response pathway of corticosteroids and cardioprotection emerged after administration of intravenous immunoglobulin. Further, we showed that complement C3 and apolipoprotein A-IV levels increased before and decreased after intravenous immunoglobulin therapy and that the insulin-like growth factor-binding protein complex acid labile subunit displayed reverse alteration before and after intravenous immunoglobulin therapy. These observations might be potential indicators of intravenous immunoglobulin function.
Our results show the differential proteomic profile of serum exosomes of patients with Kawasaki disease before and after intravenous immunoglobulin therapy, such as complement C3, apolipoprotein A-IV, and insulin-like growth factor-binding protein complex acid labile subunit. These results may be useful in the identification of markers for monitoring intravenous immunoglobulin therapy in patients with Kawasaki disease.
In this paper, we propose an integral equation approach for pricing an American-style Parisian up-and-out call option under the Black–Scholes framework. The main difficulty of pricing this option lies in the determination of its optimal exercise price, which is a three-dimensional surface, instead of a two-dimensional (2-D) curve as is the case for a “one-touch” barrier option. In our approach, we first reduce the 3-D pricing problem to a 2-D one by using the “moving window” technique developed by Zhu and Chen (2013, Pricing Parisian and Parasian options analytically. Journal of Economic Dynamics and Control, 37(4): 875-896), then apply the Fourier sine transform to the 2-D problem to obtain two coupled integral equations in terms of two unknown quantities: the option price at the asset barrier and the optimal exercise price. Once the integral equations are solved numerically by using an iterative procedure, the calculation of the option price and the hedging parameters is straightforward from their integral representations. Our approach is validated by a comparison between our results and those of the trusted finite difference method. Numerical results are also provided to show some interesting features of the prices of American-style Parisian up-and-out call options and the behaviour of the associated optimal exercise boundaries.
The Myanmar snub-nosed monkey Rhinopithecus strykeri was discovered in 2010 on the western slopes of the Gaoligong Mountains in the Irrawaddy River basin in Myanmar and subsequently in the same river basin in China, in 2011. Based on 2 years of surveying the remote and little disturbed forest of the Gaoligong Mountains National Nature Reserve in China, with outline transect sampling and infrared camera monitoring, a breeding group comprising > 70 individuals was found on the eastern slopes of the Gaoligong Mountains in the Salween River Basin. Given the Critically Endangered status of this primate (a total of < 950 individuals are estimated to remain in the wild), efforts to protect the relatively undisturbed habitat of this newly discovered population and to prevent hunting are essential for the long-term survival of this species.
We derive an analytical solution for the value of Parisian up-and-in calls by using the “moving window” technique for pricing European-style Parisian up-and-out calls. Our pricing formula can be applied to both European-style and American-style Parisian up-and-in calls, due to the fact that with an “in” barrier, the option holder cannot do or decide on anything before the option is activated, and once the option is activated it is just a plain vanilla call, which could be of American style or European style.
In this paper, a closed-form pricing formula in the form of an infinite series for European call options is derived for the Heston stochastic volatility model under a chosen martingale measure. Given that markets with the stochastic volatility are incomplete, there exists a number of equivalent martingale measures and consequently investors face a problem of making a choice of appropriate measure when they price options. The one we adopt here is the so-called minimal entropy martingale measure shown to be related to the expected utility maximization theory (Frittelli 2000 Math. Finance10(1), 39–52) and the financial rationality for choosing this measure will be further illustrated in this paper. A great advantage of our newly-derived pricing formula is that the convergence of the solution in series form can be proved theoretically; such a proof of the convergence is also complemented by some numerical examples to demonstrate the speed of convergence. To further show the validity of our formula, a comparison of prices calculated through the newly derived formula is made with those obtained directly from the Monte Carlo simulation as well as those from solving the PDE (partial differential equation) with the finite difference method.
We develop a simplified analytical approach for pricing discretely-sampled variance swaps with the realized variance, defined in terms of the squared log return of the underlying price. The closed-form formula obtained for Heston’s two-factor stochastic volatility model is in a much simpler form than those proposed in literature. Most interestingly, we discuss the validity of our solution as well as some other previous solutions in different forms in the parameter space. We demonstrate that market practitioners need to be cautious, making sure that their model parameters extracted from market data are in the right parameter subspace, when any of these analytical pricing formulae is adopted to calculate the fair delivery price of a discretely-sampled variance swap.
Protein tyrosine phosphatase 1B (PTP1B) is implicated in the negative regulation of the insulin signalling pathway by dephosphorylating the insulin receptor (IR) and IR substrates. Ganodermalucidum has traditionally been used for the treatment of diabetes in Chinese medicine; however, its anti-diabetic potency and mechanism in vivo is still unclear. Our previously published study reported a novel proteoglycan PTP1B inhibitor, named Fudan-Yueyang-Ganoderma lucidum (FYGL) from G. lucidum, with a half-maximal inhibitory concentration (IC50) value of 5·12 (sem 0·05) μg/ml, a protein:polyglycan ratio of 17:77 and 78 % glucose in polysaccharide, and dominant amino acid residues of aspartic acid, glycine, glutamic acid, alanine, serine and threonine in protein. FYGL is capable of decreasing plasma glucose in streptozotocin-induced diabetic mice with a high safety of median lethal dose (LD50) of 6 g/kg. In the present study, C57BL/6 db/db diabetic mice were trialed further using FYGL as well as metformin for comparison. Oral treatment with FYGL in db/db diabetic mice for 4 weeks significantly (P < 0·01 or 0·05) decreased the fasting plasma glucose level, serum insulin concentration and the homeostasis model assessment of insulin resistance. FYGL also controlled the biochemistry indices relative to type 2 diabetes-accompanied lipidaemic disorders. Pharmacology research suggests that FYGL decreases the plasma glucose level by the mechanism of inhibiting PTP1B expression and activity, consequently, regulating the tyrosine phosphorylation level of the IR β-subunit and the level of hepatic glycogen, thus resulting in the improvement of insulin sensitivity. Therefore, FYGL is promising as an insulin sensitiser for the therapy of type 2 diabetes and accompanied dyslipidaemia.
Postherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ). The aim of the present study was to compare the nutritional status of PHN patients with that of healthy controls, and then to identify risk factors for PHN using multivariate multiple logistic regressions. In the present cross-sectional study, we prospectively enrolled fifty PHN patients for at least 3 months and fifty healthy controls. We selected nine circulating nutrients including ionised Ca, Zn, retinol, folic acid, vitamin B12, vitamin C, α-tocopherol, γ-tocopherol and lycopene associated with both immunity and the modulation of neuropathic pain, and measured their concentrations in plasma/serum. Concentrations of ionised Ca, Zn, vitamin C and vitamin B12 were significantly lower in PHN patients than in controls after excluding those patients receiving supplements since the outbreak of HZ. The prevalence of either mild/marginal or severe deficiencies for any of the nine selected circulating nutrients in PHN patients (92 %) was much higher than that in controls (46 %) (P < 0·001). Lower concentrations of vitamin C ( ≤ 45·0 μmol/l), ionised Ca ( ≤ 1·05 mmol/l) and Zn ( ≤ 0·91 g/l) were found to increase independently the risk of PHN using binary variable (dichotomy) analyses with both PHN patients and controls in a multivariate logistic regression analysis. No significant correlations existed between the risks of PHN and the concentrations of retinol, folic acid, vitamin B12, lycopene or α:γ-tocopherol ratios. Thus, lower concentrations of circulating nutrients, namely vitamin C, ionised Ca or Zn, are probably a risk factor in Taiwanese patients with PHN.
In this paper, the ion jet generation from the interaction of an ultraintense laser pulse and a rear-side concave target is investigated analytically using a simple fluid model. We find that the ion expanding surface at the rear-side is distorted due to a strong charge-separation field, and that this distortion becomes dramatic with a singular cusp shown on the central axis at a critical time. The variation of the transverse ion velocity and the relative ion density diverge on the cusp, signaling the emergence of an on-axis ion jet. We have obtained analytical expressions for the critical time and the maximum velocity of the ion jet, and suggested an optimum shape for generating a collimated energetic ion jet. The above theoretical analysis has been verified by particle-in-cell (PIC) numerical simulations.