The composition of interstellar matter is driven by environmental parameters and results from extreme interstellar medium physico-chemical conditions. Astrochemists must rely on remote observations to monitor and analyze the interstellar solids composition. They bring additional information from the study of analogues produced in the laboratory, placed in simulated space environments. Planetologists and cosmochemists access and spectroscopically examine collected extraterrestrial material in the laboratory. Diffuse interstellar medium and molecular clouds observations set constraints on the composition of organic solids that can then be compared with collected extraterrestrial materials analyses, to shed light on their possible links.