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Obesity is highly prevalent and disabling, especially in individuals with severe mental illness including bipolar disorders (BD). The brain is a target organ for both obesity and BD. Yet, we do not understand how cortical brain alterations in BD and obesity interact.
Methods:
We obtained body mass index (BMI) and MRI-derived regional cortical thickness, surface area from 1231 BD and 1601 control individuals from 13 countries within the ENIGMA-BD Working Group. We jointly modeled the statistical effects of BD and BMI on brain structure using mixed effects and tested for interaction and mediation. We also investigated the impact of medications on the BMI-related associations.
Results:
BMI and BD additively impacted the structure of many of the same brain regions. Both BMI and BD were negatively associated with cortical thickness, but not surface area. In most regions the number of jointly used psychiatric medication classes remained associated with lower cortical thickness when controlling for BMI. In a single region, fusiform gyrus, about a third of the negative association between number of jointly used psychiatric medications and cortical thickness was mediated by association between the number of medications and higher BMI.
Conclusions:
We confirmed consistent associations between higher BMI and lower cortical thickness, but not surface area, across the cerebral mantle, in regions which were also associated with BD. Higher BMI in people with BD indicated more pronounced brain alterations. BMI is important for understanding the neuroanatomical changes in BD and the effects of psychiatric medications on the brain.
Diphtheria is a potentially devastating disease whose epidemiology remains poorly described in many settings, including Madagascar. Diphtheria vaccination is delivered in combination with pertussis and tetanus antigens and coverage of this vaccine is often used as a core measure of health system functioning. However, coverage is challenging to estimate due to the difficulty in translating numbers of doses delivered into numbers of children effectively immunised. Serology provides an alternative lens onto immunisation, but is complicated by challenges in discriminating between natural and vaccine-derived seropositivity. Here, we leverage known features of the serological profile of diphtheria to bound expectations for vaccine coverage for diphtheria, and further refine these using serology for pertussis. We measured diphtheria antibody titres in 185 children aged 6–11 months and 362 children aged 8–15 years and analysed them with pertussis antibody titres previously measured for each individual. Levels of diphtheria seronegativity varied among age groups (18.9% of children aged 6–11 months old and 11.3% of children aged 8–15 years old were seronegative) and also among the districts. We also find surprisingly elevated levels of individuals seropositive to diphtheria but not pertussis in the 6–11 month old age group suggesting that vaccination coverage or efficacy of the pertussis component of the DTP vaccine remains low or that natural infection of diphtheria may be playing a significant role in seropositivity in Madagascar.
Pertussis is a highly contagious infectious disease and remains an important cause of mortality and morbidity worldwide. Over the last decade, vaccination has greatly reduced the burden of pertussis. Yet, uncertainty in individual vaccination coverage and ineffective case surveillance systems make it difficult to estimate burden and the related quantity of population-level susceptibility, which determines population risk. These issues are more pronounced in low-income settings where coverage is often overestimated, and case numbers are under-reported. Serological data provide a direct characterisation of the landscape of susceptibility to infection; and can be combined with vaccination coverage and basic theory to estimate rates of exposure to natural infection. Here, we analysed cross-sectional data on seropositivity against pertussis to identify spatial and age patterns of susceptibility in children in Madagascar. A large proportion of individuals surveyed were seronegative; however, there were patterns suggestive of natural infection in all the regions analysed. Improvements in vaccination coverage are needed to help prevent additional burden of pertussis in the country.
Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.
Method
To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.
Results
The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.
Conclusion
These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.
The 'Goethe Yearbook,' first published in 1982, is a publication of the Goethe Society of North America and is dedicated to North American Goethe Scholarship. It aims above all to encourage and publish original English-language contributions to the understanding of Goethe and other authors of the 'Goethezeit,' while also welcoming contributions from scholars around the world. This year's volume features a cluster of exceptional essays that shed new light on Goethe's 'Wilhelm Meister' novels and 'Faust,' as well as fascinating articles on the early play 'Das Jahrmarktsfest zu Plundersweilen' and the poem 'Ilmenau,' Schiller's 'Die Räuber,' and an essay that places Goethe's thought in relation to current debates about cosmopolitanism and postcoloniality. Engaging reviews of recent publications in Goethe studies round out the volume. Contributors include Eric Denton, Matt Erlin, Jaimey Fisher, Ingrid Rieger, Rainer Kawa, David Barry, Stephanie Dawson, and John Pizer. Simon J. Richter is professor of German at the University of Pennsylvania. Book review editor Martha B. Helfer is professor of German at Rutgers University.
The 'Goethe Yearbook,' first published in 1982, is a publication of the Goethe Society of North America and is dedicated to North American Goethe scholarship. It aims above all to encourage and publish original English-language contributions to the understanding of Goethe and other authors of the 'Goethezeit,' while also welcoming contributions from scholars around the world. The book review section seeks likewise to evaluate a wide selection of recent publications on the period, and is important for all scholars of 18th-century literature. Volume 12 honors founding editor Thomas P. Saine with contributions from prominent scholars such as Ehrhard Bahr, Benjamin Bennett, Dieter Borchmeyer, Jane Brown, Jill Kowalik, Ruth Kluger, Meredith Lee, John McCarthy, Jeff Sammons, Helmut Schneider, Hans Vaget, and more. The volume includes essays on Goethe's novels, plays, and poems, the Ilmpark, Bach, Ossian, Goethe reception, and Schiller. Simon J. Richter is associate professor of German and Comparative Literature at the University of Pennsylvania. Book review editor Martha B. Helfer is associate professor of German at the University of Utah.
In Germany, Weimar Classicism (roughly the period from Goethe's return to Germany from Italy in 1788 to the death of his friend and collaborator Schiller in 1805) is widely regarded as an apogee of literary art. But outside of Germany, Goethe is considered a Romantic, and the notion of Weimar Classicism as a distinct period is viewed with skepticism. This volume of new essays regards the question of literary period as a red herring: Weimar Classicism is best understood as a project that involved the ambitious attempt not only to imagine but also to achieve a new quality of wholeness in human life and culture at a time when fragmentation, division, and alienation appeared to be the norm. By not succumbing to the myth of Weimar and its literary giants, but being willing to explore the phenomenon as a complex cultural system with a unique signature, this book provides an account of its shaping beliefs, preoccupations, motifs, and values. Contributions from leading German, British, and North American scholars open up multiple interdisciplinary perspectives on the period. Essays on the novel, poetry, drama, and theater are joined by accounts of politics, philosophy, visual culture, women writers, and science. The reader is introduced to the full panoply of cultural life in Weimar, its accomplishments as well as its excesses and follies. Emancipatory and doctrinaire by turns, the project of Weimar Classicism is best approached as a complex whole. Contributors: Dieter Borchmeyer, Charles Grair, Gail Hart, Thomas Saine, Jane Brown, Cyrus Hamlin, Roger Stephenson, Elisabeth Krimmer, Helmut Pfotenhauer, Benjamin Bennett, Astrida Orle Tantillo, W. Daniel Wilson. Simon J. Richter is associate professor of German at the University of Pennsylvania.
The 'Goethe Yearbook,' first published in 1982, is a publication of the Goethe Society of North America and is dedicated to North American Goethe Scholarship. It aims above all to encourage and publish original English-language contributions to the understanding of Goethe and other authors of the 'Goethezeit,' while also welcoming contributions from scholars around the world. Volume 14 features a special section on childhood in the Age of Goethe, co-edited with Anthony Krupp. In addition, readers will find two essays illuminating Goethe's 'Triumph der Empfindsamkeit,' an inspired reading of 'Das Märchen' against the background of Goethe's critique of Newtonian science, a careful analysis of the daemonic in the poem 'Mächtiges überraschen,' and essays on Egmont and 'Wilhelm Meisters Wanderjahre. CONTRIBUTORS: KELLY BARRY, PAUL FLEMING, EDGAR LANDGRAF, LILIANE WEISSBERG, JOHN HEINS, HEATHER L. SULLIVAN, RALEIGH WHITINGER, ANGUS NICHOLLS, ROBIN A. CLOUSER. Simon J. Richter is professor of German at the University of Pennsylvania, and book review editor Martha B. Helfer is professor of German at Rutgers University. Anthony Krupp is assistant professor of German at the University of Miami.
The Echelon-cross-Echelle Spectrograph (EXES), one of the first generation instruments for the Statospheric Observatory for Infrared Astronomy (SOFIA) will provide a unique tool for examining the ISM and star formation. The EXES high spectral resolution mode, R ≤ 120 000 from 4.5 μm to 28.3 μm, is designed for line observations of gas-phase molecules. The improved atmospheric transmission guaranteed by SOFIA will make observations of molecules such as H2O and CH4 fairly routine. EXES will also have medium and low resolution modes to enable a wide range of science projects. EXES is a PI instrument open for collaborative proposals following the model of the successful TEXES instrument (Lacy et al. 2002). It is currently scheduled for first science flights on SOFIA in 2013.
Bulk silicon-germanium (SiGe) alloys and two SiGe thick films (4 and 5 μm) on Si wafers were tested with the electron probe microanalyzer (EPMA) using wavelength dispersive spectrometers (WDS) for heterogeneity and composition for use as reference materials needed by the microelectronics industry. One alloy with a nominal composition of Si0.86Ge0.14 and the two thick films with nominal compositions of Si0.90Ge0.10 and Si0.75Ge0.25 on Si, evaluated for micro- and macroheterogeneity, will make good microanalysis reference materials with an overall expanded heterogeneity uncertainty of 1.1% relative or less for Ge. The bulk Ge composition in the Si0.86Ge0.14 alloy was determined to be 30.228% mass fraction Ge with an expanded uncertainty of the mean of 0.195% mass fraction. The thick films were quantified with WDS-EPMA using both the Si0.86Ge0.14 alloy and element wafers as reference materials. The Ge concentration was determined to be 22.80% mass fraction with an expanded uncertainty of the mean of 0.12% mass fraction for the Si0.90Ge0.10 wafer and 43.66% mass fraction for the Si0.75Ge0.25 wafer with an expanded uncertainty of the mean of 0.25% mass fraction. The two thick SiGe films will be issued as National Institute of Standards and Technology Reference Materials (RM 8905).
