The Echelon-cross-Echelle Spectrograph (EXES), one of the first generation instruments for the Statospheric Observatory for Infrared Astronomy (SOFIA) will provide a unique tool for examining the ISM and star formation. The EXES high spectral resolution mode, R ≤ 120 000 from 4.5 μm to 28.3 μm, is designed for line observations of gas-phase molecules. The improved atmospheric transmission guaranteed by SOFIA will make observations of molecules such as H2O and CH4 fairly routine. EXES will also have medium and low resolution modes to enable a wide range of science projects. EXES is a PI instrument open for collaborative proposals following the model of the successful TEXES instrument (Lacy et al. 2002). It is currently scheduled for first science flights on SOFIA in 2013.