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Uniform distribution of diamond grains is difficult to achieve using traditional fabrication of the micro grinding wheel. The design and performance of novel resinous diamond composites (RDCs) fabricated by hot pressing molding were studied to fabricate micro resinous diamond grinding wheels. The physical and mechanical properties of RDCs were analyzed by constructing and simulating five kinds of RDCs, including acrylonitrile butadiene styrene (ABS)/polyvinyl chloride (PVC)/dioctyl phthalate (DOP)/diamond materials with different mass ratios. Diamond grains presented good compatibility with the ABS–PVC–DOP copolymer, which resulted in improved mechanical properties of RDCs. RDC1–RDC5 samples were fabricated, and their hardness, surface roughness, and infrared spectra were analyzed. The optimal mass ratio of ABS/PVC/diamond/DOP for fabricating RDCs was 62.5/18.6/10.6/8.3. The results provide guidance in fabricating novel materials for resinous diamond grinding wheels with desirable performances for precision and ultraprecision machining.
SCN5A encodes sodium-channel α-subunit Nav1.5. The mutations of SCN5A can lead to hereditary cardiac arrhythmias such as the long-QT syndrome type 3 and Brugada syndrome. Here we sought to identify novel mutations in a family with arrhythmia.
Genomic DNA was isolated from blood of the proband, who was diagnosed with atrial flutter. Illumina Hiseq 2000 whole-exome sequencing was performed and an arrhythmia-related gene-filtering strategy was used to analyse the pathogenic genes. Sanger sequencing was applied to verify the mutation co-segregated in the family.
Results and conclusions
A novel missense mutation in SCN5A (C335R) was identified, and this mutation co-segregated within the affected family members. This missense mutation was predicted to result in amplitude reduction in peak Na+ current, further leading to channel protein dysfunction. Our study expands the spectrum of SCN5A mutations and contributes to genetic counselling of families with arrhythmia.
This paper presents a Chinese adaption of the Formal Characteristics of the Behavior-Temperament Inventory (FCB-TI), a self-report instrument that evaluates six temperamental scales, based on Strelau’s concept of temperament. A first sample of 626 undergraduates completed the Chinese version of the Regulative Theory of Temperament Questionnaire (RTTQ), which is an initial pool of 381 items. Internal consistency suggests adequate reliability (.66 to .82), and an exploratory factor analysis revealed a six-factor solution consistent with the original instrument. A follow-up confirmatory factor analysis revealed good support for the temperament structure with a second sample of students (N = 2.980). Internal consistency and factorial structure were re-examined (Cronbach’s alpha ranged .64 to .85), and test-retest correlations over a two-week period ranged from .82 to .96 with a third sample of adults (N = 2.265). Convergent and discriminant validity was explored in relation to the Eysenck Personality Questionnaire-Revision Short Scale for Chinese (EPQ-RSC) model dimensions. Results indicate that the Chinese version of the FCB-TI has similar psychometric properties and generally satisfactory reliability and validity.
Two self-assembling twin guanine-cytosine (G∧C) hybrid molecules featuring porphyrin (TPPO-(G∧C)2) and oligothiophene groups (6T-(G∧C)2) were synthesized. In organic solution, these molecules self-assemble into one-dimensional rosette nanotubes (RNTs) featuring the porphyrin or oligiothiophene groups on the outer surface. Using a combination of imaging and spectroscopic techniques we established the structure of the TPPO-(G∧C)2 and 6T-(G∧C)2 RNTs and compared the HOMO and LUMO energy levels with PC61BM, a well-known electron acceptor material. These studies, in combination with solid-state photoluminescence data of PC61BM-TPPO-(G∧C)2 RNT blended thin films, indicates that these self-assembled nanomaterials have great potential as electron donor materials for solution-processed organic photovoltaics.
The chemical abundances of the metal-poor stars in the stellar stream provide important information for setting constraints on models of neutron-capture processes. The study of these stars could gives us a better understanding of the r-process nucleosynthesis and chemical composition of the early Galaxy. Using the updated main r-process and weak r-process patterns, we fit abundances in the stellar stream stars. The weak r-process component coefficients are almost constant for the sample stars, including r-rich stars, which means that both the weak r-process and Fe are produced as primary elements from Type II supernovae and their yields have nearly a constant mass fraction. The difference between the stream stars and r-rich stars is obvious. For the stream stars, the fact that the increased trend in the main r-process component coefficients as metallicity increases means a gradual increase in the production of main r-process elements relative to iron. This behaviour implies that the masses of progenitors for the main r-process are smaller than those of the weak r-process. Furthermore, we find that the metal-poor stream star HD 237846 is a weak r-process star.
This study was conducted to investigate the pattern of DNA methylation in vitrified–thawed mouse oocytes and their in vitro fertilized early embryos. Firstly, mouse oocytes at metaphase II (MII) stage of meiosis were allocated randomly into three groups: (1) untreated (control); (2) exposed to vitrification solution without being plunged into liquid nitrogen (toxicity); or (3) vitrified by open-pulled straw (OPS) method (vitrification). Oocytes from all three groups were fertilized subsequently in vitro. The level of DNA methylation in the MII oocytes and their early embryos was then examined by immunofluorescence using an anti-5-methylcytosine (anti-5-MeC) monoclonal antibody and fluorescein isothiocyanate (FITC)-conjugated goat anti-mouse IgG. Developmental rates to 2-cell embryos (62.28%) and blastocysts (43.68%) of the vitrified–thawed oocytes were lower (P < 0.01) than those of fresh oocytes (81.47%, 61.99%) and vitrification solution treated (79.20%, 60.04%) oocytes. DNA methylation (as reflected by 5-MeC fluorescence intensity) in the vitrification group was less (P < 0.01) for MII oocyte and 2- to 8-cell stages compared with that in the control and toxicity groups. Accordingly, a reduction in global genomic methylation due to vitrification of MII oocytes may result in compromised in vitro developmental potential in early mouse embryos.
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