Broomrapes (Orobanche spp.) are root holoparasitic plants that cause severe damage to economically important crops, especially in Mediterranean countries. Egyptian broomrape is the most troublesome weed on tomatoes grown for processing in Israel. In the present study, we tested the efficacy and selectivity of four sulfonylurea herbicides in controlling Egyptian broomrape on tomatoes grown in pots under greenhouse conditions. MON 37500, rimsulfuron, HOE 404 and SL-160 were applied postemergence (POST) and preplant incorporated (PPI) followed by POST applications. MON 37500 and rimsulfuron were more selective to tomato and controlled the parasite more effectively than HOE 404 and SL-160. MON 37500 and rimsulfuron at 50 and 100 g ai/ha and at 100, 150, and 200 g ai/ha, respectively, applied on tomato foliage 14, 28, and 42 d after planting (DAP) and followed by sprinkler irrigation to field capacity, resulted in complete control of the parasite. However, a significant reduction in control efficacy was observed when the experiment was repeated with charcoal-topped pots, suggesting that the herbicides act mainly through the soil. Except for rimsulfuron, the PPI followed by two POST treatments was more phytotoxic to tomato plants than the POST treatments. The PPI plus POST applications controlled Egyptian broomrape effectively, but tomato plants were injured by HOE 404 at all PPI application rates and by MON 37500 at the high rate at 150 g/ha. The present study determined that three POST applications or a PPI application followed by two POST applications of MON 37500 at 50 or 100 g/ha, or rimsulfuron at 100, 150, or 200 g/ha were effective and selective in controlling Egyptian broomrape on tomato, under greenhouse conditions.