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This chapter discusses the case of a 42-year-old patient who was admitted for the evaluation of opioid-induced central sleep apnea. It presents the clinical history, examination, follow-up, treatment, and the results of the procedures performed on the patient. The patient was presented for evaluation of frequent breathing pauses during sleep, which had been witnessed by his wife for 5 years along with intermittent mild snoring. His social history was negative for alcohol or other substance abuse, but he was an ex-smoker and he drank 12 cups of coffee per day. The patient had been maintained on narcotics for treatment of his chronic pain following the laminectomy, for a period of 8 years. In view of his sleep respiratory symptoms, polysomnography (PSG) was performed. Opioid-induced central sleep apnea (CSA) has attracted attention in recent years because of the surge in opioid administration to patients with pain.
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