To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Movement disorders in systemic disease
Sheila R. Eichenseer, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA,
Deborah A. Hall, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Unlike other systemic diseases, movement disorders are infrequent in hematological disease. Although some hematological diseases, such as superficial siderosis and neuroacanthocytosis, may present initially with neurological symptoms, the majority of patients with these diseases are identified due to complications related to the underlying hematological abnormalities. Each hematological disorder will be described, with clinical manifestations, pathophysiology, and treatment, with genetic considerations if appropriate.
Hemochromatosis is characterized by enhanced intestinal absorption of dietary iron. The presence of an association between hemochromatosis and movement disorders is controversial (Russo et al. 2004). Hereditary hemochromatosis (HH), which results in iron accumulation, is a common genetic disorder, affecting 0.5 percent of the US population. It is estimated that one in ten individuals are carriers of the most frequent mutation and they are typically Caucasians of Northern European descent (Feder et al. 1996). Movement disorders in individuals with HH have only infrequently been reported in the literature. This section will summarize the cases of movement disorders in the setting of hemochromatosis described in the literature. However, it remains unclear whether these rare cases can be attributed to hemochromatosis or are coincidental.