The Northern Hemisphere ice sheets decayed rapidly during deglacial phases of the ice-age cycle, producing meltwater fluxes that may have been of sufficient magnitude to perturb oceanic circulation. The continental record of ice-sheet history is more obscured during the growth and advance of the last great ice sheets, ca. 120,000–20,000 yr B.P., but ice cores tell of high-amplitude, millennial-scale climate fluctuations that prevailed throughout this period. These climatic excursions would have provoked significant fluctuation of ice-sheet margins and runoff variability whenever ice sheets extended to mid-latitudes, giving a complex pattern of freshwater delivery to the oceans. A model of continental surface hydrology is coupled with an ice-dynamics model simulating the last glacial cycle in North America. Meltwater discharged from ice sheets is either channeled down continental drainage pathways or stored temporarily in large systems of proglacial lakes that border the retreating ice-sheet margin. The coupled treatment provides quantitative estimates of the spatial and temporal patterns of freshwater flux to the continental margins. Results imply an intensified surface hydrological environment when ice sheets are present, despite a net decrease in precipitation during glacial periods. Diminished continental evaporation and high levels of meltwater production combine to give mid-latitude runoff values that are highly variable through the glacial cycle, but are two to three times in excess of modern river fluxes; drainage to the North Atlantic via the St. Lawrence, Hudson, and Mississippi River catchments averages 0.356 Sv for the period 60,000–10,000 yr B.P., compared to 0.122 Sv for the past 10,000 yr. High-amplitude meltwater pulses to the Gulf of Mexico, North Atlantic, and North Pacific occur throughout the glacial period, with ice-sheet geometry controlling intricate patterns of freshwater routing variability. Runoff from North America is staged in the final deglaciation, with a stepped sequence of pulses through the Mississippi, St. Lawrence, Arctic, and Hudson Strait drainages.