We report on a class of hybrid sensors involving single-walled carbon nanotube field effect transistors (SWNT FET's) functionalized with various oligonucleotides. These oligonucleotides include ten sequences of single stranded DNA and two sequences of single stranded. We show that the sequence of the adsorbed oligonucleotide is the key component in determining the response that the hybrid will experience upon exposure to a panel of five volatile organic compounds (VOC's). Our sensors present a change in conductance, which is specific to the analyte being tested, and the adsorbed species. Our devices respond and recover quickly (seconds), and are reproducible over ∼100 cycles. These traits are highly desirable for the creation of a technology for use as an electronic nose. We present a database of responses involving hundreds of devices.