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  • Chapter 6 - Mortality and Morbidity of Medication-Resistant Epilepsy

  • Edited by John M. Stern, Raman Sankar, Michael Sperling
  • Book:
    Medication-Resistant Epilepsy
    Published online:
    20 August 2020
    Print publication:
    10 September 2020, pp 39-50

  • Summary

    There is significant mortality and morbidity associated with medication-resistant epilepsy, with attendant major impact on physical, psychological, emotional, socioeconomic and other aspects of the lives of persons with epilepsy and their families. Emphasis on these issues is an imperative that is often underappreciated or overlooked, with subsequent far-reaching consequences that may be avoidable. Young adults with active epilepsy from low socioeconomic groups are more likely to die prematurely, and important contributors to mortality include comorbid disorders, such as cardiovascular diseases, cancer and unintentional injuries [1]. Notably, deaths from direct epilepsy-related causes occur in about 10% of cases, but are likely to be underestimated [2]. In this chapter, we examine the risks, types, impact and governing factors of mortality and morbidity in the population of persons with intractable epilepsy. We also discuss the commonest category of death in the intractable population – sudden unexpected death in epilepsy (SUDEP).