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This study aims to investigate the prevalence and genotype distribution of anal human papillomavirus (HPV) infection among men with different sexual orientations with or without human immunodeficiency virus (HIV) in China. A cross-sectional study was conducted during 2016–2017 in Taizhou City, Zhejiang Province. Convenient sampling was used to recruit male participants from HIV voluntary counselling and testing clinics and Center for Disease Control and Prevention. A face-to-face questionnaire interview was administered and an anal-canal swab was collected for HPV genotyping. A total of 160 HIV-positive and 113 HIV-negative men participated in the study. The prevalence of any type HPV was 30.6% for heterosexual men, 74.1% for homosexual and 63.6% for bisexual men among HIV-positive participants, while the prevalence was 8.3%, 29.2% and 23.8% respectively among HIV-negatives. The most prevalent genotypes were HPV-58 (16.9%), HPV-6 (15.6%) and HPV-11 (15.0%) among HIV-positive men, and were HPV-16 (4.4%), HPV-52 (4.4%) and HPV-6 (3.5%) among HIV-negative men. Having ever had haemorrhoids and having ever seen blood on tissue after defaecation was associated with HPV infection. One-fourth of the HPV infections in this study population can be covered by the quadrivalent vaccine in market. The highly prevalent anal HPV infection among men especially HIV-infected men calls for close observation and further investigation for anal cancer prevention.
Using whole-genome sequence (WGS) data are supposed to be optimal for genome-wide association studies and genomic predictions. However, sequencing thousands of individuals of interest is expensive. Imputation from single nucleotide polymorphisms panels to WGS data is an attractive approach to obtain highly reliable WGS data at low cost. Here, we conducted a genotype imputation study with a combined reference panel in yellow-feather dwarf broiler population. The combined reference panel was assembled by sequencing 24 key individuals of a yellow-feather dwarf broiler population (internal reference panel) and WGS data from 311 chickens in public databases (external reference panel). Three scenarios were investigated to determine how different factors affect the accuracy of imputation from 600 K array data to WGS data, including: genotype imputation with internal, external and combined reference panels; the number of internal reference individuals in the combined reference panel; and different reference sizes and selection strategies of an external reference panel. Results showed that imputation accuracy from 600 K to WGS data were 0.834±0.012, 0.920±0.007 and 0.982±0.003 for the internal, external and combined reference panels, respectively. Increasing the reference size from 50 to 250 improved the accuracy of genotype imputation from 0.848 to 0.974 for the combined reference panel and from 0.647 to 0.917 for the external reference panel. The selection strategies for the external reference panel had no impact on the accuracy of imputation using the combined reference panel. However, if only an external reference panel with reference size >50 was used, the selection strategy of minimizing the average distance to the closest leaf had the greatest imputation accuracy compared with other methods. Generally, using a combined reference panel provided greater imputation accuracy, especially for low-frequency variants. In conclusion, the optimal imputation strategy with a combined reference panel should comprehensively consider genetic diversity of the study population, availability and properties of external reference panels, sequencing and computing costs, and frequency of imputed variants. This work sheds light on how to design and execute genotype imputation with a combined external reference panel in a livestock population.
Grounded on the premise that dust particles are charged hard balls, the analysis in Davletov et al. (Contrib. Plasma Phys., vol. 56, 2016, 308) provides an original pseudopotential model of intergrain interaction in complex (dusty) plasmas. This accurate model is engaged herein to consistently treat the finite-size effects from the process of dust particle charging to determination of the thermodynamic quantities and the dust-acoustic wave dispersion in the strongly coupled regime. The orbital motion limited approximation is adopted to evaluate an electric charge of dust grains immersed in a neutralizing background of the buffer plasma. To account for finite dimensions of dust particles, the radial distribution function is calculated within the reference hypernetted-chain (RHNC) approximation to demonstrate a well-pronounced short-range order formation at rather large values of the coupling parameter and the packing fraction. The evaluated excess pressure of the dust component is compared to the available theoretical approaches and the simulation data and is then used to predict the dust-acoustic wave (DAW) dispersion in the strongly coupled regime under the assumption that the dust particles charge varies in the course of propagation. In contrast to many previous investigations, it is demonstrated for the first time ever that for DAWs the charge variation of dust particles should necessarily be taken into account while evaluating the dust isothermal compressibility.
Diarrhea is a common cause of morbidity and mortality and the incidence of diarrhea in the world has changed little over the past four decades. To assess the prevalence of and healthcare practices for diarrhea, a cross-sectional study was conducted in Pudong, Shanghai, China. In October 2014, a total of 5324 community residents were interviewed. Respondents were asked if they had experienced diarrhea (defined as ⩾3 passages of watery, loose, bloody, or mucoid stools within a 24-h period) in the previous month prior to the interview. The monthly prevalence of diarrhea was 4·1% (95% CI: 3·3–4·8), corresponding to an incidence rate of 0·54 episodes per person-year. The proportion of individuals with diarrhea who sought healthcare was 21·2% (95% CI: 13·4–29·0). Diarrhea continues to impose a considerable burden on the community and healthcare system in Pudong. Young age and travel were identified as predictors of increased diarrhea occurrence.
An in-depth look at diffusion mechanics within lithium-ion electrodes under fast charging conditions is presented. Electrochemical impedance spectroscopy is used as the primary technique to investigate lithium diffusion within electrode material and in electrolyte near the electrode-electrolyte interface. Half-cells of silicon are charged under varying galvanostatic rates while obtaining impedance data. Collected data is analyzed with the help of an electrical equivalent circuit model that provides mechanical and electrochemical parameters for each instance. The novelty of this equivalent circuit partly lies in its ability to resolve between solid-phase diffusion and liquid-phase diffusion, both of which occur during cycling of a lithium-ion electrode. Observed patterns in the parameters of this circuit provide insight into impact of fast charging on mechanics of lithium diffusion, both inside the electrode matrix and within electrolyte.
The objective of this study was to evaluate the potential of using Multiplex 3, a hand-held canopy fluorescence sensor, to determine rice nitrogen (N) status at different growth stages. In 2013, a paddy rice field experiment with five N fertilizer treatments and two varieties was conducted in Northeast China. Field samples and fluorescence data were collected simultaneously at the panicle initiation (PI), stem elongation (SE), and heading (HE) stages. Four N status indicators, leaf N concentration (LNC), plant N concentration (PNC), plant N uptake (PNU) and N nutrition index (NNI), were determined. The preliminary results indicated that different N application rates significantly affected most of the fluorescence variables, especially the simple fluorescence ratios (SFR_G, SFR_R), flavonoid (FLAV), and N balance indices (NBI_G, NBI_R). These variables were highly correlated with N status indicators. More studies are needed to further evaluate the accuracy of rice N status diagnosis using fluorescence sensing at different growth stages.
Background: Historically, description of patient visual acuity and visual field changes following intracranial procedures has been very rudimentary. Clinicians and researchers have relied on the use of vague descriptions like “improved”, “worsened”, and “unchanged” to describe outcomes following resections of tumours affecting the optic apparatus, which are difficult to quantify in a clinical setting. Methods: We present a novel way to describe a patient’s visual function as a combination of visual acuity and visual field assessment that is simple to use and can be used by surgeons, and researchers to gauge visual outcomes following tumour resection. Results: With our scale we were able to capture the overall visual change while being sensitive enough to define the overall quantity of improvement or worsening quantitatively, using categories that are clinically relevant and understandable. Conclusions: The implementation of pre- and post- operative assessment provides clinically relevant information for surgeons and is robust for routine use.
Pig farmers and veterinarians have high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) due to the occupational livestock exposure, while few reported this association on slaughterhouse workers. We conducted this cross-sectional study to explore the phenotypic and molecular characteristics of S. aureus and MRSA in slaughterhouse pig-related workers and control workers in Guangdong Province, China. Participants were interviewed and provided two nasal swabs. Swabs were tested for S. aureus, and isolates were further tested for antimicrobial susceptibility, virulence genes and multi-locus sequence typing. Compared with control workers, pig-related workers have significantly higher prevalence of MRSA carriage (adjusted odd ratio (aOR) 3·70, 95% CI 1·63–8·40). The proportions of MRSA resistant to clindamycin, erythromycin, tetracycline or chloromycetin were significantly higher in pig-related workers than in control workers. The predominant phenotypes of S. aureus were resistant to penicillin, clindamycin, erythromycin and tetracycline. Three MRSA CC9 isolates with livestock-associated characteristics (resistance to tetracycline and absence of immune evasion cluster (IEC) genes) were detected in pig-related workers but not in control workers. For human-associated CCs (CC7, CC59, CC6, and CC188), there was no significant difference in IEC profile or antimicrobial resistance between the groups. These findings reveal that there may be a potential risk for livestock-to-human transmission of LA-MRSA and human-to-human transmission of human-associated MRSA.
In this paper, we perform an absolute equation of state (EOS) measurement on the principal Hugoniot of aluminum using a near-symmetric impact method. The flyer plates are accelerated to high velocities using the laser-ramp-driven method. An aluminum flyer plate of ~25 µm is accelerated to the velocity range from 4 to 12 km/s. Then the aluminum flyer plate propagates across a vacuum gap and impacts with an aluminum step target. A line-imaging optical recording velocity interferometer for any reflector (ORVIS) is used to measure the aluminum flyer plate and the shock velocity simultaneously. Aluminum EOS data were measured with pressures range from 50 to 200 GPa. This absolute EOS measurement method may be used for studying a variety of materials.
The 2083 m Vostok Antarctic ice core provides a unique opportunity for access to many paleoclimatic and paleo-environmental proxy data. This core, which has been dated by using a glaciological model, fully covers the last glacial-interglacial cycle, and goes back to the ice age which preceded the last interglaciai (−160 ka B P ).
A continuous deuterium record is now available and we have interpreted it in terms of local temperature changes. This record is dominated by the large 100 ka glacial-inter-glacial oscillation, with a maximum temperature amplitude of about 11°C; the long Last Glacial period is very well documented and it is confirmed that the warmest part of the Last Interglaciai period was about 2°C warmer than the Holocene. Comparison with the ice-volume marine record shows that the Vostok climate record is of relatively large geographical significance, which makes it possible to establish, over the last 160 ka, the link between worldwide climatic changes and the Vostok dust record that we present here.
This dust content corresponds to the non-soluble microparticles. It was obtained on a discontinuous basis (1 sample = about ∼10 m). Due to the very low concentration of some samples (down to 20 x 10−9gg−1) and cracks in the ice from the first 1000 m depth, we used stringent decontamination procedures. Size distribution and total concentration were measured, using a Coulter counter and an optical microscope; the results were tested against chemical measurements (aluminium concentration). In previous studies, it has been shown that the main proportion of insoluble microparticles is of terrigenous origin and represents the small-sized (radius <2 μm) dust produced on the continents.
The Vostok record displays an increase in dust concentration of up to 20 times during the coldest climatic periods, coupled with the presence of larger particles. It confirms, on a much longer time-scale, a characteristic previously noted in Antarctic and Greenland ice cores over the Last Glacial Maximum. This large increase is attributed to a greater areal extent of global tropical aridity during the cold periods, coupled with higher efficiency of atmospheric circulation in respect of dust production and transport. Beyond this, the relationship between the dust input and the successive stages during the Last Glacial is now very well documented and will be discussed with a view to correlating the Vostok climatic record with other marine and terrestrial paleodata.
As a kind of flash heat source, intense pulsed ion beam (IPIB) can be used for material surface modification. The ablation effect has important influence on interaction between IPIB and material. Therefore, the understanding of ablation mechanism is of great significance to IPIB application. In this work, pure zinc targets were irradiated and ablated by IPIB. In the ablation process under the different ion beam energy densities, the ablation products were collected by a monocrystalline silicon substrate. By analyzing the ablation products with scanning electron microscope and energy-dispersive spectrometer, the surface morphology, and the spatial distribution of ablation products quantity were obtained. The results are useful for clearing the ablation process and the influence of beam parameter on the ablation effect.
Personality may predispose family caregivers to experience caregiving differently in similar situations and influence the outcomes of caregiving. A limited body of research has examined the role of some personality traits for health-related quality of life (HRQoL) among family caregivers of persons with dementia (PWD) in relation to burden and depression.
Data from a large clinic-based national study in South Korea, the Caregivers of Alzheimer's Disease Research (CARE), were analyzed (N = 476). Path analysis was performed to explore the association between family caregivers’ personality traits and HRQoL. With depression and burden as mediating factors, direct and indirect associations between five personality traits and HRQoL of family caregivers were examined.
Results demonstrated the mediating role of caregiver burden and depression in linking two personality traits (neuroticism and extraversion) and HRQoL. Neuroticism and extraversion directly and indirectly influenced the mental HRQoL of caregivers. Neuroticism and extraversion only indirectly influenced their physical HRQoL. Neuroticism increased the caregiver's depression, whereas extraversion decreased it. Neuroticism only was mediated by burden to influence depression and mental and physical HRQoL.
Personality traits can influence caregiving outcomes and be viewed as an individual resource of the caregiver. A family caregiver's personality characteristics need to be assessed for tailoring support programs to get the optimal benefits from caregiver interventions.
EVA foams, like all other polymers, also exhibit strain-rate effects and hysteresis. However, currently available approaches for predicting the mechanical response of polymeric foam subjected to an arbitrarily imposed loading history and strain-rate effect are highly limited. Especially, the strain rates in the intermediate rate domain (between 100 and 102 s–1) are extremely difficult to study. The use of data generated through the drop tower technique for implementation in constitutive equations or numerical models has not been considered in past studies. In this study, an experiment including a quasi-static compression test and drop impact tests with a high speed camera was conducted. An inverse analysis technique combined with a finite element model for material parameter identification was developed to determine the stress–strain behavior of foam at different specific strain rates. It was used in this study to simulate multiple loading and unloading cycles on foam specimens, and the results were compared with experimental measurements.
This paper presents a parameterized gait generator based on linear inverted
pendulum model (LIPM) theory, which allows users to generate a natural gait
pattern with desired step sizes. Five types of zero moment point (ZMP)
components are proposed for formulating a natural ZMP reference, where ZMP moves
continuously during single support phases instead of staying at a fixed point in
the sagittal and lateral plane. The corresponding center of mass (CoM)
trajectories for these components are derived by LIPM theory. To generate a
parameterized gait pattern with user-defined parameters, a gait planning
algorithm is proposed, which determines related coefficients and boundary
conditions of the CoM trajectory for each step. The proposed parameterized gait
generator also provides a concept for users to generate gait patterns with
self-defined ZMP references by using different components. Finally, the
feasibility of the proposed method is validated by the experimental results with
a teen-sized humanoid robot, David, which won first place in the sprint event at
the 20th Federation of International Robot-soccer Association (FIRA) RoboWorld
This list contains radiocarbon dates of archaeologic samples of wood, charcoal, and peat measured between 1967 and 1973, analyzed by the Laboratory of the Institute of Archaeology, Leningrad Branch, USSR Academy of Sciences. The samples measured include charcoal from cultural strata and hearths, wood from kurgans and cultural strata, peat, etc, coll from various archaeologic sites by Soviet scientists, as well as a series from Dashly site, Afghanistan.
The suppression of interferences from atomic and molecular isobars is a key requirement for the extension of accelerator mass spectrometry (AMS) to the analysis of new cosmogenic isotopes and for increasing the range of applications for small AMS systems. In earlier work, it was shown that unwanted isobars can be eliminated by anion-gas reactions (Litherland et al. 2007). Recently, a prototype system in which such reactions could be applied to ions from an AMS ion source, the Isobar Separator for Anions (ISA), was described (Eliades et al. 2009). This system decelerates the beam of rare anions from keV to eV energies, guides them through a single radiofrequency quadrupole (RFQ) gas cell, and re-accelerates them for further analysis in a 2.5MV AMS system. Tests of this system with Cl and S anions and NO2 gas showed a suppression of S with respect to Cl of over 6 orders of magnitude, with a transmission of ∼30% for the Cl beam. In this work, results of the analysis of a range of standard reference materials are reported; these show the linearity of the system for measuring the 36Cl/35Cl ratio over a span of 2 orders of magnitude. Further tests, using the AMS system as a diagnostic tool, have provided clues about the loss of Cl at higher cell pressure and the nature of the residual low level of S transmission. These lead to the assessment of various gases for cooling the Cl– beam. Suppression measurements for 41K in the analysis of 41Ca, using NO2 as a reaction gas, are also discussed. These preliminary measurements have provided data for the development of a more advanced system with separate cooling and reaction cells.
During the period, work on the problem of the Earth’s rotation has continued to expand and increase its scope. The total number of institutions engaged in the determination of the Earth’s rotation parameters (ERP) by different techniques has been increased significantly. The rotation of the Earth is currently measured by classical astrometry, Doppler and laser satellite tracking, laser ranging of the Moon, and radio interferometry. Several long time series of the ERP are available from most of these techniques, in particular, those made during the Main Campaign of the MERIT project. The various series have been intercompared and their stability, in the time frame of years to days, has been estimated for the purposes of establishing a new conventional terrestrial reference system (COTES). On the other hand, the difficulties of maintaining a regular operation for laser ranging to the Moon (LLR) have been recognized. It resulted in the proposal to organize an one-month campaign of observations in 1985 in order to complement the COTES collocation program and to allow additional intercomparisons with other techniques.
During the period, there have been several major events which have effected the scope and interest of Commission 19. The most significant of these has been the dissolution of the BIH and IPMS and their replacement by the International Earth Rotation Service (IERS). The correlation of higher frequency fluctuations in the Earth’s rotation rate with changes in the Earth’s Atmospheric Angular Momentum is also significant. Many investigators now seem to believe that the “decade variations„ in the Earth’s rotation rate are caused by torques between the core and mantle caused by the uneven motions at the core-mantle boundary. These events and discoveries have made this an exciting period. It seems that the future holds more in the way of discovery due to the utilization of the more accurate and precise Earth rotation data coming from the modern observing techniques.