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The yield strength, the failure strength and strain behavior of Isotactic Polypropylene are all a function of the molecular orientation in the polymer. Further, although Isotactic Polypropylene and PMDA-ODA polyimide are very different polymers, they behave similarly when the strain rate is slow enough for the polymer to be at the low strain rate limit of its failure envelope. A master True Stress-Total True Strain curve is obtained for both polymers.
Patients with early cervical cancer (FIGO stage IB1 or less) are conventionally considered treated with a surgical approach while those with more advanced disease are treated by radiotherapy with concurrent chemotherapy. Dargent's operation is the realization of a laparoscopic pelvic lymph-node dissection associated with a radical cervical amputation through a vaginal approach. Dargent's operation or radical trachelectomy enables preservation of fertility among women with early cervical cancer. The benefits of Dargent's operation are linked to the laparoscopic approach, which reduces the risk of adhesions on pelvis organs and the vaginal route that allows the preservation of uterine body and its optimal vascularization. Following the excellent results achieved by the Dargent's operation, several teams have proposed operating variants through laparotomy or laparoscopy. These modifications are subject to criticism because they are usually associated with the section of the uterine arteries and, thus, with a partial devascularization of the uterus.
The specialty of fertility preservation offers patients with cancer, who are rendered infertile by chemo- and radiotherapy, the opportunity to realize their reproductive potential. This gold-standard publication defines the specialty. The full range of techniques and scientific concepts is covered in detail, and the author team includes many of the world's leading experts in the field. The book opens with introductions to fertility preservation in both cancer and non-cancer patients, followed by cancer biology, epidemiology and treatment, and reproductive biology and cryobiology. Subsequent sections cover fertility preservation strategies in males and females, including medical/surgical procedures, ART, cryopreservation and transplantation of both ovarian tissue and the whole ovary, and in-vitro follicle growth and maturation. Concluding chapters address future technologies, as well as ethical, legal and religious issues. Richly illustrated throughout, this is a key resource for all clinicians specializing in reproductive medicine, gynecology, oncology, hematology, endocrinology and infertility.
Loss of fertility in adult life is a major psychologically traumatic consequence of cancer treatment. Improving therapeutic regimens using less gonadotoxic protocols could enable spontaneous recovery of spermatogenesis, but their use is not always possible without compromising patient survival. Cryopreservation of testicular tissue pieces may be considered as an alternative method capable of maintaining cell-to-cell contacts between Sertoli and germinal stem cells, and therefore preserving the stem cell niche necessary for their survival and subsequent maturation. In humans, preclinical in vitro studies using cadaver or surgically removed testes have demonstrated the feasibility of transplanting germ cell suspensions into testes. The first convincing demonstration of human testis transplantation was reported in 1978. The most important, life-threatening concern of spermatogonial transplantation is the risk of reintroducing malignant cells. Providing young people undergoing gonadotoxic treatment with adequate fertility preservation strategies is a challenging area of reproductive medicine.