Purple and yellow nutsedge are problematic weeds in Florida small fruit and vegetable production. EPTC and fomesafen are PRE herbicides that suppress both nutsedge species, but field application in Florida has shown control to be erratic. Greenhouse experiments were conducted in Gainesville, FL, from May to August 2014 and in Wimauma, FL, from March to May 2015 to investigate susceptibility of purple and yellow nutsedge to EPTC and fomesafen applications. Treatments included EPTC at 2.91 kg ai ha−1 and fomesafen at 0.42 kg ai ha−1 at 0, 3, 6, 9, 12, and 15 d after planting (DAP) tubers, plus a nontreated control. EPTC and fomesafen applications averaged across timings decreased purple and yellow nutsedge emergence, shoot height, leaf number, and shoot mass compared to the nontreated control. Herbicide applications 0 DAP reduced purple nutsedge emergence greater than 65% compared to the nontreated control and caused at least 74% injury 4 wk after planting. Herbicide applications 0 DAP decreased yellow nutsedge emergence and shoot mass compared to the nontreated control by at least 86 and 93%, respectively. Applications of EPTC and fomesafen have the ability to suppress short-term purple and yellow nutsedge growth. Applications made at or prior to tuber sprouting maximize herbicide efficacy.