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Ruminants are recognised to suffer from Cu-responsive disorders. Present understanding of Cu transport and metabolism is limited and inconsistent across vets and veterinary professionals. There has been much progress from the studies of the 1980s and early 1990s in cellular Cu transport and liver metabolism which has not been translated into agricultural practice. Cu metabolism operates in regulated pathways of Cu trafficking rather than in pools of Cu lability. Cu in the cell is chaperoned to enzyme production, retention within metallothionein or excretion via the Golgi into the blood. The hepatocyte differs in that Cu-containing caeruloplasmin can be synthesised to provide systemic Cu supply and excess Cu is excreted via bile. The aim of the present review is to improve understanding and highlight the relevant progress in relation to ruminants through the translation of newer findings from medicine and non-ruminant animal models into ruminants.
The principal aim of this study was to develop, pilot and evaluate an intervention intended to support the development of resilience and self-efficacy in parents of children with disabilities or complex health needs.
Previous research has found that families often experience physical, social and emotional stress in the context of living with and caring for their disabled child. The literature indicates that a key factor in determining how well the parents of these children cope with their situation may be how resilient and self-efficacious they are.
A total of 16 parents of children with complex needs and disabilities were engaged in a series of guided conversations delivered during six contact visits with nurse co-researchers (community children’s nurses who had received an intensive three-day preparation programme). The conversations, which were supported with additional material that was designed specifically for use in the study, were based around four key themes: emotional coping, practical coping, support networks and ‘you and your child’. The impact of the intervention was evaluated using both qualitative and quantitative measures.
When interviewed, parents reported increased self-belief and self-confidence and indicated that they felt better supported and stronger as a result of the intervention. This was consistent with the quantitative evaluation which identified significant improvements on scores for active coping and self-blame on the brief COPE inventory scale and for empathy and understanding and self-acceptance on the TOPSE scale. Scores on the self-report distress thermometer demonstrated a significant reduction in self-reported distress scores at the end of the intervention period.
Optimising oilseed rape canopy size through correct management is crucial for maximising yield. Plant growth regulators (PGRs) and nitrogen (N) fertiliser are generally applied at a flat rate, however variable applications may be useful for the optimisation of canopy size. The aim of this paper was to understand the potential for spectral reflectance indices to predict green area index (GAI) and crop N content in winter oilseed rape, with specific focus on the Fritzmeier Isaria Crop Sensor. Three large oilseed rape chessboard experiments were set up in 2015 and 2016 in the UK. The results show good correlations between the Isaria indices and both GAI and crop N content, suggesting that the Isaria may be a useful tool for variably applying PGRs and N fertiliser to oilseed rape.
A range of precision farming technologies are used commercially for variable rate applications of nitrogen (N) for cereals, yet these usually adjust N rates from a pre-set value, rather than predicting economically optimal N requirements on an absolute basis. This paper reports chessboard experiments set up to examine variation in N requirements, and to develop and test systems for its prediction, and to assess its predictability. Results showed very substantial variability in fertiliser N requirements within fields, typically >150 kg ha−1, and large variation in optimal yields, typically >2 t ha−1. Despite this, calculated increases in yield and gross margin with N requirements perfectly matched across fields were surprisingly modest (compared to the uniform average rate). Implications are discussed, including the causes of the large remaining variation in grain yield, after N limitations were removed.
This is a case study concerning the rate at which probabilistic coupling occurs for nilpotent diffusions. We focus on the simplest case of Kolmogorov diffusion (Brownian motion together with its time integral or, more generally, together with a finite number of iterated time integrals). We show that in this case there can be no Markovian maximal coupling. Indeed, there can be no efficient Markovian coupling strategy (efficient for all pairs of distinct starting values), where the notion of efficiency extends the terminology of Burdzy and Kendall (2000). Finally, at least in the classical case of a single time integral, it is not possible to choose a Markovian coupling that is optimal in the sense of simultaneously minimizing the probability of failing to couple by time t for all positive t. In recompense for all these negative results, we exhibit a simple efficient non-Markovian coupling strategy.
In this paper we describe a perfect simulation algorithm for the stable M/G/c queue. Sigman (2011) showed how to build a dominated coupling-from-the-past algorithm for perfect simulation of the super-stable M/G/c queue operating under first-come-first-served discipline. Sigman's method used a dominating process provided by the corresponding M/G/1 queue (using Wolff's sample path monotonicity, which applies when service durations are coupled in order of initiation of service). The method exploited the fact that the workload process for the M/G/1 queue remains the same under different queueing disciplines, in particular under the processor sharing discipline, for which a dynamic reversibility property holds. We generalise Sigman's construction to the stable case by comparing the M/G/c queue to a copy run under random assignment. This allows us to produce a naïve perfect simulation algorithm based on running the dominating process back to the time it first empties. We also construct a more efficient algorithm that uses sandwiching by lower and upper processes constructed as coupled M/G/c queues started respectively from the empty state and the state of the M/G/c queue under random assignment. A careful analysis shows that appropriate ordering relationships can still be maintained, so long as service durations continue to be coupled in order of initiation of service. We summarise statistical checks of simulation output, and demonstrate that the mean run-time is finite so long as the second moment of the service duration distribution is finite.
Cryptosporidium, a parasite known to cause large drinking and recreational water outbreaks, is tolerant of chlorine concentrations used for drinking water treatment. Human laboratory-based surveillance for enteric pathogens detected a cryptosporidiosis outbreak in Baker City, Oregon during July 2013 associated with municipal drinking water. Objectives of the investigation were to confirm the outbreak source and assess outbreak extent. The watershed was inspected and city water was tested for contamination. To determine the community attack rate, a standardized questionnaire was administered to randomly sampled households. Weighted attack rates and confidence intervals (CIs) were calculated. Water samples tested positive for Cryptosporidium species; a Cryptosporidium parvum subtype common in cattle was detected in human stool specimens. Cattle were observed grazing along watershed borders; cattle faeces were observed within watershed barriers. The city water treatment facility chlorinated, but did not filter, water. The community attack rate was 28·3% (95% CI 22·1–33·6), sickening an estimated 2780 persons. Watershed contamination by cattle probably caused this outbreak; water treatments effective against Cryptosporidium were not in place. This outbreak highlights vulnerability of drinking water systems to pathogen contamination and underscores the need for communities to invest in system improvements to maintain multiple barriers to drinking water contamination.
Consider the following random spatial network: in a large disk, construct a network using a stationary and isotropic Poisson line process of unit intensity. Connect pairs of points using the network, with initial/final segments of the connecting path formed by travelling off the network in the opposite direction to that of the destination/source. Suppose further that connections are established using ‘near geodesics’, constructed between pairs of points using the perimeter of the cell containing these two points and formed using only the Poisson lines not separating them. If each pair of points generates an infinitesimal amount of traffic divided equally between the two connecting near geodesics, and if the Poisson line pattern is conditioned to contain a line through the centre, then what can be said about the total flow through the centre? In Kendall (2011) it was shown that a scaled version of this flow has asymptotic distribution given by the 4-volume of a region in 4-space, constructed using an improper anisotropic Poisson line process in an infinite planar strip. Here we construct a more amenable representation in terms of two ‘seminal curves’ defined by the improper Poisson line process, and establish results which produce a framework for effective simulation from this distribution up to an L1 error which tends to 0 with increasing computational effort.
This paper describes the system architecture of a newly constructed radio telescope – the Boolardy engineering test array, which is a prototype of the Australian square kilometre array pathfinder telescope. Phased array feed technology is used to form multiple simultaneous beams per antenna, providing astronomers with unprecedented survey speed. The test array described here is a six-antenna interferometer, fitted with prototype signal processing hardware capable of forming at least nine dual-polarisation beams simultaneously, allowing several square degrees to be imaged in a single pointed observation. The main purpose of the test array is to develop beamforming and wide-field calibration methods for use with the full telescope, but it will also be capable of limited early science demonstrations.
Consumption of almonds has been shown to be associated with a decreased risk of CHD, which may be related to their fatty acid (FA) composition. However, the effect of almond consumption on the serum FA composition is not known. Therefore, in the present study, we investigated whether almond consumption would alter the serum FA profile and risk of CHD, as calculated using Framingham's 10-year risk score, in a dose-dependent manner in hyperlipidaemic individuals when compared with a higher-carbohydrate control group using dietary interventions incorporating almonds. A total of twenty-seven hyperlipidaemic individuals consumed three isoenergetic (mean 1770 kJ/d) supplements during three 1-month dietary phases: (1) full-dose almonds (50–100 g/d); (2) half-dose almonds with half-dose muffins; (3) full-dose muffins. Fasting blood samples were obtained at weeks 0 and 4 for the determination of FA concentrations. Almond intake (g/d) was found to be inversely associated with the estimated Framingham 10-year CHD risk score (P= 0·026). In both the half-dose and full-dose almond groups, the proportions of oleic acid (OA) and MUFA in the TAG fraction (half-almond: OA P= 0·003; MUFA P= 0·004; full-almond: OA P< 0·001; MUFA P< 0·001) and in the NEFA fraction (half-almond: OA P= 0·01; MUFA P= 0·04; full-almond: OA P= 0·12; MUFA P= 0·06) increased. The estimated Framingham 10-year CHD risk score was inversely associated with the percentage change of OA (P= 0·011) and MUFA (P= 0·016) content in the TAG fraction. The proportions of MUFA in the TAG and NEFA fractions were positively associated with changes in HDL-cholesterol concentrations. Similarly, the estimated Framingham 10-year CHD risk score was inversely associated with the percentage change of OA (P= 0·069) and MUFA content in the NEFA fraction (P= 0·009). In conclusion, the results of the present study indicate that almond consumption increases OA and MUFA content in serum TAG and NEFA fractions, which are inversely associated with CHD lipid risk factors and overall estimated 10-year CHD risk.
Starting from the assumption that meaning in electroacoustic music is an outcome of the listener's mental processes, it is the goal of this essay to explicate the mental processes whereby feeling and emotion contribute to meaning when listening to electroacoustic music. This essay begins with a broad consideration of feeling and emotion with an eye toward artistic experience, spanning from basic emotions to nuanced phenomenal qualities. It then introduces the concept of mental layers in support of the multi-levelled nature of meaning, especially in this case, meaning that is felt as well as comprehended. These two preliminary topics precede the introduction of the feeling blend, an extension of blend theory as presented by Fauconnier and Turner (2002). Core issues for blend theory, such as what constitutes a mental space and what triggers a blend, are reconsidered in the light of practical examples from the literature of electroacoustic music. In conclusion, the feeling blend is proposed as an essential concept to understanding artistic experience and an intrinsic aspect of being human.
Consumer health organisations (CHOs), which operate outside the mainstream healthcare system with a specific focus on supporting people to self-manage their health conditions, have become widespread. Yet, there has been little systematic research into CHOs, including their perceived benefits and barriers, which encourage or deter their access by people with a variety of chronic health conditions.
This study explored the benefits of CHOs in self-management and also the barriers that inhibit their access, from the perspective of people with chronic conditions and their unpaid carers.
In-depth, semi-structured interviews were completed with 97 participants across four regions of Australia. The sample included a high representation of people from culturally and linguistically diverse backgrounds and Aboriginal and Torres Strait Islander people as well as non-indigenous Australians.
Three inter-related themes were identified that represented the benefits of involvement and participation in CHOs: knowledge and information, connection and support and experiential learning. However, limited access pathways emerged as a barrier that inhibited a person’s entry into CHOs. Furthermore, the person’s beliefs and experiences about their own health condition(s) also inhibited their continued participation in CHO programmes.
Although our findings confirm that CHOs are a valuable resource in alleviating the ‘work of being a patient’ for some people, there seems to be some barriers that prevent their full access and utilisation. Structured integration systems to increase the reliable delivery and accessibility of CHOs are needed to ensure that people who would benefit from accessing them can do so.