This chapter examines ways in which technology can provide a medium for innovative design and the delivery of instruction that can result in new ways of learning and high levels of student engagement. Scaffolding can be a cognitive support for problem solving or motivational support to help learners realize their potential. BioWorld is a technology-rich learning environment designed to support medical students as they develop clinical reasoning skills. As stated earlier, the educational platforms are varied; they include pedagogical agents that serve as intelligent virtual tutors that employ language, facial expressions, and gestures to create effective learning experiences; simulation-based environments for promoting team effectiveness in trauma units; multimedia game environments to promote reasoning; virtual reality to provide immersive learning experiences; communication based video technologies to promote cross-cultural and cross-disciplinary teaching experiences; and social networking tools that are reusable for creating new knowledge.