The objective of this study was to test the potential for using a single-entry procedure to revegetate Russian knapweed– and green rabbitbrush–infested rangeland. I hypothesized that simultaneously applying an herbicide and seeding in the fall would produce the highest establishment and growth of desired species. For Russian knapweed, treatments included three seeding rates (zero, low, and high) and two herbicides (with and without clopyralid plus 2,4-D) applied in either the spring (2003) or fall (2004). The seed mixture included pubescent wheatgrass, Siberian wheatgrass, and alfalfa. Grasses were seeded on October 21, 2003 (fall dormant), and April 5, 2004 (spring), using a no-till rangeland drill. The seeding rates consisted of 3.4, 6.8, and 9.3 (low) or 5.0, 9.0, and 12.3 (high) kg ha−1 of alfalfa, Siberian wheatgrass, and pubescent wheatgrass, respectively. For green rabbitbrush, treatments included two seeding levels (13.5 kg ha−1 of Siberian wheatgrass and not seeded) and three herbicides (clopyralid, dicamba, and 2,4-D) and a control applied in July. Clopyralid plus 2,4-D (0.21 plus 1.12 kg ha−1) and dicamba at 2.1 kg ha−1 gave 61 and 66% control of Russian knapweed and green rabbitbrush, respectively. Herbicides interacted with seeding to provide the highest density of seeded species on the Russian knapweed site. These data support the hypothesis that simultaneously applying an herbicide and seeding in the fall would produce the highest establishment and growth of desired species. Conversely, only seeding affected Siberian wheatgrass establishment on the rabbitbrush sites. It may be reasonable to seed Siberian wheatgrass without controlling rabbitbrush if forage production is the primary objective.