Glyphosate effectively controls most weeds in glyphosate-resistant soybean. However, it is sometimes only marginally effective on Ipomoea spp. A field experiment was conducted at five locations in North Carolina to determine the effects of mixing 2,4-DB with glyphosate on Ipomoea spp. control and on soybean injury and yield. The isopropylamine salt of glyphosate at 560, 840, and 1,120 g ai/ha controlled mixtures of tall morningglory, entireleaf morningglory, and red morningglory at least 96% at two locations. Mixing the dimethylamine salt of 2,4-DB at 35 g ae/ha with glyphosate did not increase control but reduced soybean yield 6%. At two other locations, 2,4-DB increased control of tall morningglory and a mixture of entireleaf morningglory and ivyleaf morningglory 13 to 22% when mixed with glyphosate at 560 g/ha, but not when mixed with glyphosate at 840 or 1,120 g/ha. Soybean yield was reduced 31% at one location and was unaffected at the other. At the fifth location, 2,4-DB increased control of tall morningglory 25, 11, and 7% when mixed with glyphosate at 560, 840, and 1,120 g/ha, respectively. Soybean yield was increased 15%. In separate field experiments, glyphosate at 560, 840, and 1,120 g/ha controlled large crabgrass at least 99%. Mixing 2,4-DB at 35 g/ha with glyphosate did not affect control. In the greenhouse, mixing 2,4-DB at 35, 70, 140, or 280 g/ha with glyphosate at 70 to 560 g/ha did not affect large crabgrass control by glyphosate.