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The interaction of water with synthetically prepared goethite (α-FeOOH) and amorphous hyd-rated ferric oxide surfaces was studied using i.r. absorption and water vapor adsorption measurements. I.R. results show that the last traces of physically adsorbed water are removed from the amorphous material by outgassing at 25°C. In contrast, goethite retains approximately a monolayer of physically adsorbed water with similar outgassing. This monolayer of water on goethite, which is presumably hydrogen-bonded at least in part with structural hydroxyls, is readily exchangeable with D2O.
Integral entropies of adsorption were evaluated from water vapor adsorption isotherms at 15, 25 and 35°C and compared with values for mobile and immobile layers calculated through application of statistical mechanics (McCafferty and Zettlemoyer, 1970). Entropy values for both the first physically adsorbed monolayer of water on the amorphous material and the second monolayer on goethite were about the same as or greater than those calculated for an immobile layer, indicating strong hydrogen bonding of water by both surfaces. The larger deviation between the entropy values for goethite and those calculated for the immobile layer may be associated with changes in the structure of the first as well as the second physically adsorbed water layers. Surface areas, calculated using the BET method, were 320 and 32 m2 g-1 for the amorphous material and goethite respectively. Since the unit surface activity is probably about the same for the two materials, it follows that as the amorphous material crystallizes to form goethite, there would be a reduction in total surface activity in proportion to the reduction in surface area.
Whole-genome sequencing (WGS) shotgun metagenomics (metagenomics) attempts to sequence the entire genetic content straight from the sample. Diagnostic advantages lie in the ability to detect unsuspected, uncultivatable, or very slow-growing organisms.
Objective:
To evaluate the clinical and economic effects of using WGS and metagenomics for outbreak management in a large metropolitan hospital.
Design:
Cost-effectiveness study.
Setting:
Intensive care unit and burn unit of large metropolitan hospital.
Patients:
Simulated intensive care unit and burn unit patients.
Methods:
We built a complex simulation model to estimate pathogen transmission, associated hospital costs, and quality-adjusted life years (QALYs) during a 32-month outbreak of carbapenem-resistant Acinetobacter baumannii (CRAB). Model parameters were determined using microbiology surveillance data, genome sequencing results, hospital admission databases, and local clinical knowledge. The model was calibrated to the actual pathogen spread within the intensive care unit and burn unit (scenario 1) and compared with early use of WGS (scenario 2) and early use of WGS and metagenomics (scenario 3) to determine their respective cost-effectiveness. Sensitivity analyses were performed to address model uncertainty.
Results:
On average compared with scenario 1, scenario 2 resulted in 14 fewer patients with CRAB, 59 additional QALYs, and $75,099 cost savings. Scenario 3, compared with scenario 1, resulted in 18 fewer patients with CRAB, 74 additional QALYs, and $93,822 in hospital cost savings. The likelihoods that scenario 2 and scenario 3 were cost-effective were 57% and 60%, respectively.
Conclusions:
The use of WGS and metagenomics in infection control processes were predicted to produce favorable economic and clinical outcomes.
Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.
Aims
To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.
Method
Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.
Results
Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.
Conclusions
AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
Due to lack of data on the epidemiology, cardiac, and neurological complications among Ontario visible minorities (Chinese and South Asians) affected by coronavirus disease (COVID-19), this population-based retrospective study was undertaken to study them systematically.
Methods:
From January 1, 2020 to September 30, 2020 using the last name algorithm to identify Ontario Chinese and South Asians who were tested positive by PCR for COVID-19, their demographics, cardiac, and neurological complications including hospitalization and emergency visit rates were analyzed compared to the general population.
Results:
Chinese (N = 1,186) with COVID-19 were found to be older (mean age 50.7 years) compared to the general population (N = 42,547) (mean age 47.6 years) (p < 0.001), while South Asians (N = 3,459) were younger (age of 42.1 years) (p < 0.001). The 30-day crude rate for cardiac complications among Chinese was 169/10,000 (p = 0.069), while for South Asians, it was 64/10,000 (p = 0.008) and, for the general population, it was 112/10,000. For neurological complications, the 30-day crude rate for Chinese was 160/10,000 (p < 0.001); South Asians was 40/10,000 (p = 0.526), and general population was 48/10,000. The 30-day all-cause mortality rate was significantly higher for Chinese at 8.1% vs 5.0% for the general population (p < 0.001), while it was lower in South Asians at 2.1% (p < 0.001).
Conclusions:
Chinese and South Asians in Ontario affected by COVID-19 during the first wave of the pandemic were found to have a significant difference in their demographics, cardiac, and neurological outcomes.
Lawyers and judges often make arguments based on history - on the authority of precedent and original constitutional understandings. They argue both to preserve the inspirational, heroic past and to discard its darker pieces - such as feudalism and slavery, the tyranny of princes and priests, and the subordination of women. In doing so, lawyers tame the unruly, ugly, embarrassing elements of the past, smoothing them into reassuring tales of progress. In a series of essays and lectures written over forty years, Robert W. Gordon describes and analyses how lawyers approach the past and the strategies they use to recruit history for present use while erasing or keeping at bay its threatening or inconvenient aspects. Together, the corpus of work featured in Taming the Past offers an analysis of American law and society and its leading historians since 1900.
Field studies were conducted to determine the influence of annual herbicide treatments plus cultivation on weed populations and corn yields in ridge-till corn during a 3-yr period at Mitchell, NE, and a 7-yr period at North Platte, NE. When the experiment was initiated at North Platte, no weeds were present before corn planting. It took 4 yr before triazine-resistant kochia became a problem before corn planting in plots treated with atrazine, but these were controlled by other operations prior to corn harvest. In the cultivated check, green foxtail densities before harvest increased from 0 in 1985 to 32 plants 100 m−2 in 1991. Annual applications of dicamba plus 2,4-D 10 d early preplant followed by cultivation controlled triazine-resistant kochia and velvetleaf, but common lambsquarters, nightshade species, and green foxtail increased. Volunteer corn was controlled with cultivation. After 3 yr at Mitchell, the annual weed population increased 10-fold in the cultivated check. Thus, corn yields were reduced 64% with two cultivations compared with an annual early preplant application of dicamba plus 2,4-D followed by alachlor plus cyanazine PRE and two cultivations. With two cultivations under low annual weed populations at North Platte, grain yield from the cultivated check treatment was not different from annual treatments of herbicides after 7 yr. Metolachlor plus atrazine occasionally caused a reduction in corn grain yields.
Research conducted since 1979 in the north central United States and southern Canada demonstrated that after repeated annual applications of the same thiocarbamate herbicide to the same field, control of some difficult-to-control weed species was reduced. Laboratory studies of herbicide degradation in soils from these fields indicated that these performance failures were due to more rapid or “enhanced” biodegradation of the thiocarbamate herbicides after repeated use with a shorter period during which effective herbicide levels remained in the soils. Weeds such as wild proso millet [Panicum miliaceum L. spp. ruderale (Kitagawa) Tzevelev. #3 PANMI] and shattercane [Sorghum bicolor (L.) Moench. # SORVU] which germinate over long time periods were most likely to escape these herbicides after repeated use. Adding dietholate (O,O-diethyl O-phenyl phosphorothioate) to EPTC (S-ethyl dipropyl carbamothioate) reduced problems caused by enhanced EPTC biodegradation in soils treated previously with EPTC alone but not in soils previously treated with EPTC plus dietholate. While previous use of other thiocarbamate herbicides frequently enhanced biodegradation of EPTC or butylate [S-ethyl bis(2-methylpropyl)carbamothioate], previous use of other classes of herbicides or the insecticide carbofuran (2,3 -dihydro-2,2 -dimethyl-7-benzofuranyl methylcarbamate) did not. Enhanced biodegradation of herbicides other than the thiocarbamates was not observed.
[This was the second part of the Introduction to the Law & Society Review’s 1975 Festschrift for Hurst. Much has since been written on Hurst’s contributions to legal history, some of the best of it in a Symposium on Hurst’s work in 18 Law & History Review 1 (2000).]
[This short essay appeared in a Symposium organized by the Georgetown Law Review to memorialize E. P. Thompson after his death in August, 1993. 82 Georgetown Law Review 2005 (1994). Thompson did not see himself as a “legal” historian, but was one of the first to recognize that both official law and popular law and custom pervasively structured social relationships, and he exerted a powerful influence on American as well as British social-legal historiography.]
[This essay is a somewhat revised and expanded version of the Thomas M. Cooley Lectures given at the University of Michigan Law School in February of 1993.]
[This was the second part of the Introduction to the Law & Society Review’s 1975 Festschrift for Hurst. Much has since been written on Hurst’s contributions to legal history, some of the best of it in a Symposium on Hurst’s work in 18 Law & History Review 1 (2000).]
[This essay first appeared in 10 Law & Society Review 9 (1975), as the first part of an introduction to a Festschrift for the Wisconsin social-legal historian James Willard Hurst. Its aim was to sketch the history of American legal historiography before Hurst came on the scene and to explain how Hurst broke with the tradition of largely “internal” legal history. (In this collection, the essay is split into two parts, with the second part on Hurst’s contributions – “James Willard Hurst – Social Legal History’s Pioneer” – in the section on “Legal Historians” that follows this one.) Since this was written several notable works have amplified and added much valuable detail to the account given here – most especially of legal history-writing in the nineteenth century: John Burrow, A Liberal Descent: Victorian Historians and the English Past (1981); Stephen Siegel, “Historism in Late Nineteenth Century Constitutional Thought,” 1990 Wis. L. Rev. 1431; Kunal Parker, Common Law, History and Democracy in America, 1790–1900: Legal Thought Before Modernism (2011); and David M. Rabban, Law’s History: American Legal Thought and the Transatlantic Turn to History (2012).]
[This piece was published as part of a Symposium commemorating the 100th anniversary of O. W. Holmes, Jr., The Common Law in 10 Hofstra Law Review 719 (1982). Its attempt to place Holmes’s legal theory in its formative intellectual context has been followed by a massive and distinguished literature on Holmes. I think the best of this work is a fine intellectual biography by G. Edward White, Justice Oliver Wendell Holmes: Law and the Inner Self (1993); a thorough and probing examination of Holmes’s contributions to and views on legal history in David M. Rabban, Law’s History: American Legal Thought and the Transatlantic Turn to History (2013); Louis Menand’s illuminating exploration of Holmes’s pragmatist Cambridge circle in The Metaphysical Club: A Story of Ideas in America (2001); and especially Thomas Grey’s penetrating essay on “Holmes and Legal Pragmatism,” 42 Stanford Law Review 787 (1989). Grey’s essay has convinced me that I was wrong in the piece that follows to see the conceptualism of Holmes’s early essays in analytical jurisprudence as existing in unresolved contradiction with his later historicism. Grey persuasively argues that Holmes’s purpose in refining the logical arrangement of legal doctrine into conceptual categories was the modest pragmatic one of making current law more accessible and predictable to lawyers. But his historicism taught him that any such arrangements, including his own, must be transient and provisional, saturated as all law is with the contingent and irrational cultural beliefs and political struggles of its time and place.]
[This was my brief contribution to the Symposium on Willard Hurst in 18 Law & History Review 167 (2000). The Symposium generally is the best source of recent reassessments of Hurst’s work and influence].
[This essay consolidates drafts of several public talks given in various venues, ranging from the scholarly (Wesleyan University, Yale Law School, University of Southern California) to the political (American Constitution Society meetings) between about 2005 and the present day. These talks were more frankly partisan and polemical than most of my writing and possibly less generous to opposing views than they should have been; but their main points still seem to me basically right.]
[This essay, published in 90 Yale Law Journal 1017 (1981) was written for a Symposium on Legal Scholarship held at Yale Law School in 1981. It was my first attempt to explain the nature of the threat that I believe historicism poses to legal theory and legal reasoning; and to describe the leading ways we have of coping with the threat. Prominent among those ways is what is called here “adaptation theory,” which in “Critical Legal Histories,” the essay that follows, becomes “evolutionary functionalism.”]
[This was written for a Symposium on the work of Morton Horwitz at the University of Tulsa Law School and originally published in 37 Tulsa Law Review 915 (2002).]