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Page 1 of 4

Case Studies in Assisted Reproduction
  • Case Studies in Assisted Reproduction
  • Common and Uncommon Presentations
  • Edited by Nick S. Macklon, Human M. Fatemi, Robert J. Norman, Pasquale Patrizio
  • Published online: 05 February 2015
  • Print publication: 22 January 2015
  • View description
    Clinical case studies have long been recognized as a useful adjunct to problem-based learning and continuing professional development. They emphasize the need for clinical reasoning, integrative thinking, problem-solving, communication, teamwork and self-directed learning - all desirable generic skills for health care professionals. This volume contains a selection of cases on assisted reproduction that will inform and challenge reproductive medicine practitioners at all stages in their careers. Both common and uncommon cases are included. The aim is to reinforce diagnostic skill through careful analysis of individual presenting patterns, and to guide treatment decisions. Each case consists of a clinical history, examination findings and special investigations, before a diagnosis is made. Clinical issues raised by each case are discussed and major teaching points emphasized. Selective references are provided. The book provides a useful complementary adjunct to existing textbooks of reproductive medicine, and an excellent resource for teaching and continuing professional development.
  • 31 - Obesity and oocyte quality
    • from Section 5 - Pathology
    • By Rebecca L. Robker, The Robinson Institute Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia, Robert J. Norman, The Robinson Institute Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia
  • Edited by Alan Trounson, Roger Gosden, Ursula Eichenlaub-Ritter, Universität Bielefeld, Germany
  • Book: Biology and Pathology of the Oocyte
  • Published online: 05 October 2013
  • Print publication: 24 October 2013, pp 362-370
  • View extract

    Summary

    Introduction

    Obesity has become one of the most urgent nutritional and health issues of our time. Globally, the number of obese people is at a historical high with the incidence continuing to rise. Obesity is prevalent in young women [1] and latest predictions indicate that in the USA and UK 40–50% of women will be obese by 2030 [2]. A neglected complication of obesity is female infertility as well as increased risk of polycystic ovary syndrome (or PCOS), a prevalent endocrine disorder which manifests with both metabolic symptoms including insulin resistance and dyslipidemia, as well as reproductive complications such as anovulation. Entering pregnancy in an obese condition predisposes both mother and fetus to significant health problems that can complicate an already risky pregnancy.

    It is increasingly evident that obesity is a self-perpetuating transgenerational disease that is transmitted from mothers to the next generation. While obesity alters body metabolism and leads to consequences in multiple aspects of the reproductive system, this chapter will summarize the available data from experimental animal models and clinical studies showing an impact on oocyte developmental potential. This rapidly accumulating evidence, particularly from animal models, demonstrates that obesity affects oocyte maturation and the earliest stages of embryo development; alterations that have lasting consequences on the metabolism and developmental programming of the progeny.

Page 1 of 4

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