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214 results

Page 1 of 11

  • Simultaneous cochlear implantation and removal of acoustic neuroma: implications for hearing
  • S Roberts, B Levin, H Sanli, R Ferch, K Kong, R Eisenberg
  • Journal: The Journal of Laryngology & Otology / Volume 134 / Issue 6 / June 2020
  • Published online by Cambridge University Press: 17 June 2020, pp. 519-525
  • Print publication: June 2020
  • View abstract
    Objective

    To present our data evaluating the feasibility of simultaneous cochlear implantation with resection of acoustic neuroma.

    Methods

    This paper describes a case series of eight adult patients with a radiologically suspected acoustic neuroma, treated at a tertiary referral centre in Newcastle, Australia, between 2012 and 2015. Patients underwent cochlear implantation concurrently with removal of an acoustic neuroma. The approach was translabyrinthine, with facial nerve monitoring and electrically evoked auditory brainstem response testing. Standard post-implant rehabilitation was employed, with three and six months’ follow-up data collected. The main outcome measures were: hearing, subjective benefit of implant, operative complications and tumour recurrence.

    Results

    Eight patients underwent simultaneous cochlear implantation with resection of acoustic neuroma over a 3-year period, and had 25–63 months’ follow up. There were no major complications. All patients except one gained usable hearing and were daily implant users.

    Conclusion

    Simultaneous cochlear implantation with resection of acoustic neuroma has been shown to be a safe treatment option, which will be applicable in a wide range of clinical scenarios as the indications for cochlear implantation continue to expand.

  • Tutorial on the Visualization of Volumetric Data Using tomviz
  • Barnaby D.A. Levin, Yi Jiang, Elliot Padgett, Shawn Waldon, Cory Quammen, Chris Harris, Utkarsh Ayachit, Marcus Hanwell, Peter Ercius, David A. Muller, Robert Hovden
  • Journal: Microscopy Today / Volume 26 / Issue 1 / January 2018
  • Published online by Cambridge University Press: 05 January 2018, pp. 12-17
  • Print publication: January 2018
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    Tomography produces complex volumetric datasets containing the entire internal structure and density of an object in three dimensions (3D). Interpreting volumetric data requires 3D visualization but needs specialized software distinguishable from more familiar tools used in animation for 3D surface data. This tutorial reviews 3D visualization techniques for volumetric data using the open-source tomviz software package. A suite of tools including two-dimensional (2D) slices, surface contours, and full volume rendering provide quantitative and qualitative analysis of volumetric information. The principles outlined here are applicable to a wide range of 3D tomography techniques and can be applied to volumetric datasets beyond materials characterization.

  • A Simple Preparation Method for Full-Range Electron Tomography of Nanoparticles and Fine Powders
  • Elliot Padgett, Robert Hovden, Jessica C. DaSilva, Barnaby D. A. Levin, John L. Grazul, Tobias Hanrath, David A. Muller
  • Journal: Microscopy and Microanalysis / Volume 23 / Issue 6 / December 2017
  • Published online by Cambridge University Press: 11 December 2017, pp. 1150-1158
  • Print publication: December 2017
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    Electron tomography has become a valuable and widely used tool for studying the three-dimensional nanostructure of materials and biological specimens. However, the incomplete tilt range provided by conventional sample holders limits the fidelity and quantitative interpretability of tomographic images by leaving a “missing wedge” of unknown information in Fourier space. Imaging over a complete range of angles eliminates missing wedge artifacts and dramatically improves tomogram quality. Full-range tomography is usually accomplished using needle-shaped samples milled from bulk material with focused ion beams, but versatile specimen preparation methods for nanoparticles and other fine powders are lacking. In this work, we present a new preparation technique in which powder specimens are supported on carbon nanofibers that extend beyond the end of a tungsten needle. Using this approach, we produced tomograms of platinum fuel cell catalysts and gold-decorated strontium titanate photocatalyst specimens. Without the missing wedge, these tomograms are free from elongation artifacts, supporting straightforward automatic segmentation and quantitative analysis of key materials properties such as void size and connectivity, and surface area and curvature. This approach may be generalized to other samples that can be dispersed in liquids, such as biological structures, creating new opportunities for high-quality electron tomography across disciplines.

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