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34 results

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  • Chapter 10 - Olfactory Dysfunction in Parkinson’s Disease and Related Disorders
  • Edited by Néstor Gálvez-Jiménez, Florida International University, Amos D Korczyn, Tel-Aviv University, Ramón Lugo-Sanchez
  • Book: Non-motor Parkinson's Disease
  • Published online: 05 March 2022
  • Print publication: 10 March 2022, pp 99-114
  • View extract

    Summary

    Smell dysfunction is among the earliest and most salient non-motor signs of Parkinson’s disease (PD), occurring in an estimated 90% of so-called sporadic cases years before the onset of the classic motor symptoms. Until olfaction is tested formally, the vast majority of PD patients are unaware of their loss, which is usually less than total. The smell problem is rarely identified by neurologists, reflecting, in part, their failure to enquire about smell function let alone testing the olfactory nerve formally. The Quality Standards Committee of the American Academy of Neurology has designated olfactory dysfunction as one of the key diagnostic criteria for PD [1] and the Movement Disorder Society has recommended olfactory testing in the diagnosis of PD [2] and in the identification of prodromal PD [3].

Smell and Taste Disorders
  • Smell and Taste Disorders
  • Christopher H. Hawkes, Richard L. Doty
  • Published online: 17 January 2018
  • Print publication: 25 January 2018
  • View description
    Loss of the sense of smell or taste is often a sign of neurological disease. Evaluating chemosensation (the senses of smell and taste) during neurological examination can help early detection of neurodegenerative conditions such as Parkinson's and Alzheimer's disease. The importance of such testing is now receiving increasingly high profile in the medical curriculum. In this book, olfactory conditions are completely updated and the sense of taste is now included in similar detail. It is written by experts in the field, covering anatomy and physiology of human olfaction and taste, how they can be measured and their relevance to a wide range of major disorders such as diabetes, kidney disease, Alzheimer's and Parkinson's disease. The 'Olfactory Vector Hypothesis' that suggests a neuropathogen may enter the nose en route to the brain is evaluated in detail. This introduction to smell and taste disorders is an essential guide for neurologists, neurosurgeons, otolaryngologists, medical trainees, and chemosensory scientists.

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