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4 results

  • 18 - The acute effects of cannabinoids in patients with psychotic illness
  • Edited by David Castle, University of Melbourne, Robin M. Murray, Deepak Cyril D'Souza, Yale University, Connecticut
  • Book: Marijuana and Madness
  • Published online: 05 November 2011
  • Print publication: 27 October 2011, pp 198-209
  • View abstract

    Summary

    To explore whether cannabis has a potential role in actually causing bipolar disorder, a general population cohort study design is informative. Cahill et al. reviewed the interactions between chronic cannabis use and cognitive compromise in bipolar disorder. In trying to understand the interaction between the cannabis and bipolar disorder, attention has been given to the endocannabinoid system. Ashton et al. have detailed the mechanisms of the endocannabinoid system that have been implicated in brain reward pathways, pain, sleep, mood and anxiety. The authors have acknowledged the difficulties with studying the cannabinoids, including issues with doses, mode of administration and tolerance. There is no doubt a great deal of comorbidity between bipolar disorder and cannabis use. There is also a growing body of evidence regarding the deleterious effects of cannabis use in patients with bipolar disorder.
  • Psychosis reactivity to cannabis use in daily life: an experience sampling study
  • Cécile Henquet, Jim van Os, Rebecca Kuepper, Philippe Delespaul, Maurice Smits, Joost À Campo, Inez Myin-Germeys
  • Journal: The British Journal of Psychiatry / Volume 196 / Issue 6 / June 2010
  • Published online by Cambridge University Press: 02 January 2018, pp. 447-453
  • Print publication: June 2010
  • View abstract
    Background

    Little is known about the experiential dynamics of the interaction between cannabis and vulnerability to psychosis.

    Aims

    To examine the effects of cannabis on psychotic symptoms and mood in patients with psychosis and healthy controls.

    Method

    Patients with a psychotic disorder (η = 42) and healthy controls (η = 38) were followed in their daily lives using a structured time-sampling technique.

    Results

    Daily life cannabis use predicted subsequent increases in positive affect and in patients, but not in controls, decreases in negative affect. In patients, but not in controls, cannabis use predicted increased levels of hallucinatory experiences. Mood-enhancing properties of cannabis were acute, whereas psychosis-inducing effects were sub-acute. There was no direct evidence for self-medication effects in daily life.

    Conclusions

    Patients with psychosis are more sensitive to both the psychosis-inducing and mood-enhancing effects of cannabis. The temporal dissociation between acute rewarding effects and sub-acute toxic influences may be instrumental in explaining the vicious circle of deleterious use in these patients.

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