Open science is a new concept for the practice of experimental laboratory-based research, such as drug discovery. The authors have recently gained experience in how to run such projects and here describe some straightforward steps others may wish to take towards more openness in their own research programmes. Existing and inexpensive online tools can solve many challenges, while some psychological barriers to the free sharing of all data and ideas are more substantial.

Over the past few years electroconvulsive therapy (ECT) has come under increased scrutiny in the UK, with the first systematic review of patients' experiences and new national guidelines. Our aim in this article is to translate recent and sometimes confusing research and policy statements into practical guidance that benefits patients. We examined the evidence on the permanent memory and cognitive effects of ECT, with a focus on delineating their nature, understanding how ECT may cause them, informing prospective patients about them, and assessing their impact on former patients. We describe a simple and effective method for assessing retrograde amnesia. Data do not exist at this time to confirm the mechanisms by which ECT exerts its adverse effects, but clinicians should fully inform patients of the possible permanent adverse effects of the treatment, which include amnesia, memory disability and cognitive disability, and should provide follow-up testing using relevant instruments.

Barotropic and baroclinic tides were simulated for the Weddell Sea using ROMS. The model estimates for both tidal elevations and velocities showed good agreement with existing observations. The rms differences were 9 cm for elevations and 1.2–1.7 cm s−1 for the major axes of the tidal ellipses for the semidiurnal constituents and 6–8 cm and 4.5 cm s−1 for the diurnal constituents, respectively. Most of the discrepancies occurred deep under the ice shelf for the semidiurnal tides and along the continental slope for the diurnal tides. Along the continental slope, the model overestimated the generation of diurnal continental shelf waves. The diurnal tides were barotropic throughout the basin. However, internal tides were generated at semidiurnal frequencies over rough topography. Over the continental slope, semidiurnal baroclinic tidal generation was enhanced by the existence of continental shelf waves, through their harmonics. Baroclinic tides generated over rough topography in the northern Weddell Sea incited inertial oscillations as they propagated south. These inertial oscillations varied with depth since they were incited at different depths at different times as the internal tide progressed. Both the baroclinic tides and inertial oscillations induced vertical shear in the water column and increased the divergence of the horizontal surface velocities.

The barotropic and baroclinic tides in the Ross Sea were simulated using a primitive equation, sigma-coordinate model, the Regional Ocean Model System (ROMS), for four tidal constituents, M2, S2, K1, and O1. Small elevation amplitudes were predicted over most of the basin, with a combined standard deviation of 30–50 cm. Larger amplitudes, with standard deviations ranging from 50–70 cm, occurred deep within the ice shelf cavity, over the continental slope, and over Iselin Bank. Most of the elevation response was associated with the diurnal constituents (K1 and O1), as was most of the depth-independent (barotropic) velocity response. Baroclinic tides were generated at locations of steep topography for the semidiurnal constituents, but not the diurnal. Diurnal continental shelf waves were generated by the diurnal tides and found to amplify the semidiurnal elevations and baroclinic tidal velocities over the continental slope. Comparisons with observations in both elevation and velocities showed very good agreement for the semidiurnal constituents (M2 and S2) and moderate agreement for the diurnal constituents (K1 and O1). The disagreement for the diurnal constituents was associated with diurnal frequency continental shelf waves, which were overexcited along the shelf break. The baroclinic tides induced both small-scale horizontal and vertical shear in the velocity fields in the Ross Sea.

In certain regions of the Southern Ocean, tidal energy is believed to foster the mixing of different water masses, which eventually contribute to the formation of deep and bottom waters. The Ross Sea is one of the major ventilation sites of the global ocean abyss and a region of sparse tidal observations. We investigated M2 tidal dynamics in the Ross Sea using a three-dimensional sigma coordinate model, the Regional Ocean Model System (ROMS). Realistic topography and hydrography from existing observational data were used with a single tidal constituent, the semi-diurnal M2. The model fields faithfully reproduced the major features of the tidal circulation and had reasonable agreement with ten existing tidal elevation observations and forty-two existing tidal current measurements. The differences were attributed primarily to topographic errors. Internal tides were generated at the continental shelf/slope break and other areas of steep topography. Strong vertical shears in the horizontal velocities occurred under and at the edges of the Ross Ice Shelf and along the continental shelf/slope break. Estimates of lead formation based on divergence of baroclinic velocities were significantly higher than those based on barotrophic velocities, reaching over 10% at the continental shelf/slope break.

The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) RNA is known to interact with the 40S ribosomal subunit alone, in the absence of any additional initiation factors or Met-tRNAi. Previous work from this laboratory on the 80S and 48S ribosomal initiation complexes involving the HCV IRES showed that stem-loop III, the pseudoknot domain, and some coding sequence were protected from pancreatic RNase digestion. Stem-loop II is never protected by these complexes. Furthermore, there is no prior evidence reported showing extensive direct binding of stem-loop II to ribosomes or subunits. Using direct analysis of RNase-protected HCV IRES domains bound to 40S ribosomal subunits, we have determined that stem-loops II and III and the pseudoknot of the HCV IRES are involved in this initial binding step. The start AUG codon is only minimally protected. The HCV-40S subunit binary complex thus involves recognition and binding of stem-loop II, revealing its role in the first step of a multistep initiation process that may also involve rearrangement of the bound IRES RNA as it progresses.

A survey of Scottish psychiatric rehabilitation and support services, carried out in 1983 (McCreadie et al, 1985), found that although there were wide between-hospital differences, the National Health Service in Scotland was making considerable efforts to provide services for the long-term mentally ill. However, services provided by local authorities were seriously deficient.

Of all known schizophrenics living in Nithsdale, south-west Scotland, 146 (88%) were examined for the presence of the three principal movement disorders secondary to antipsychotic medication, namely akathisia, tardive dyskinesia and Parkinsonism. Of these, 18% had akathisia, 5% pseudoakathisia, 29% tardive dyskinesia, 8% persistent tardive dyskinesia, and 27% Parkinsonism. No movement disorder was seen in 44%, 36% had one and 20% had more than one movement disorder. Plasma neuroleptic levels at the time of clinical assessment were measured by the radioreceptor technique. Correlations between dose and plasma level were low; the ratio of mean plasma concentration to mean dose was greatest with fluphenazine decanoate and lowest for sulpiride. The concentration:dose ratio was higher in the elderly. There was no relationship between neuroleptic levels and akathisia, Parkinsonism or tardive dyskinesia. Additional psychotropic medication influenced neuroleptic levels. In 9% of patients receiving oral antipsychotic medication, no drug was detected in plasma.

Obstetric histories of 54 schizophrenic patients and 114 siblings were obtained from their mothers and scored using the Obstetric Complications Scale. There was no statistically significant difference in the proportion of schizophrenic patients (35%) and siblings (29%) who had at least one definite obstetric complication. There was no evidence that schizophrenic patients with a history of obstetric complications were less likely to have a first-degree relative with a history of psychiatric illness leading to in-patient care. Schizophrenic patients with a history of obstetric complications were more likely to have drug-induced Parkinsonism. There was a trend for tardive dyskinesia to be more common in those schizophrenic patients with no obstetric complications but a family history of schizophrenia.