The public career of M. Ulpius Appuleius Eurykles spanned most of the second half of the second century. He is recorded as a representative of his native city Aezani at the Panhellenion in Athens for the year 156/7. This was probably the last year of his four-year term. During that period Eurykles distinguished himself in the eyes of both his fellow Panhellenes and Athenian society for, after he left Athens and returned to Asia, four letters of commendation were sent on his behalf: two to Aezani and two to the koinon of Asia. A fifth letter was also directed by the Panhellenion to the emperor Antoninus Pius in which the virtues of Eurykles were drawn to his attention.