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This study was a retprospective review on use of electroconvulsive therapy (ECT) in a Military Medical Academy, Belgrade, Serbia. Aim of the study was to determine demographic and clinical predictors of ECT outcome.
Method:
The study subjects were 120 patients (59 male and 61 female) treated with bilateral ECT over the period 2000-2004. Data extracted from clinical records included demographic variables (age, sex, education and heredity of psychiatric illness) and clinical characteristics (diagnosis, duration of illness, episode duration, comorbid psychiatric disorders, presence of psychosis, previous hospitalizations, and ECT variables). As outcome measure was used Clinical Global Impression (CGI) scale.
Results:
The significant sex difference was found concerning age and diagnosis. Female patients were much older (mean age=46.9 years, SD=14.3) compared to male patients (mean age=35.4 years, SD=14.1), with much longer duration of illness (mean=88.7 months, SD=95.8), compared to male patients (51.9 months, SD=58.1). After a clinical course of ECT, 52.5% of all patients were rated as "much", and 40% as "very much" improved on the CGI. Statistically significant predictors of remission were sex and the number of previous hospitalizations.
Conclusion:
Significant improvement after use of electroconvulsive therapy was associated with sex and the number of previous hospitalizations, but not with age or duration of illness or presence of psychosis.
Single-photon emission computed tomography (SPECT) is a valid method for measuring regional cerebral blood flow (rCBF). Recent studies regarding rCBF in patients with first episode psychosis (FEP) reported heterogeneous results, but were limited with small sample size. Neuroimaging can help us in setting the diagnosis of illness, as well as in following the progress and finding more effective treatment for psychotic disorders.
Objectives
To compare, baseline alterations of the rCBF using SPECT with psychopathological status in FEP during acute phase.
Aims
To investigate the changes of rCBF in patients with FEP during acute phase.
Methods
We conducted a study on 40 drug – naïve patients with FEP at acute phase of illness during their hospitalization at Zagreb University hospital centre. The diagnosis was confirmed using diagnostic and statistical manual of mental disorders, fifth edition. rCBF was measured with SPECT and psychopathological status rated with the Positive and Negative Syndrome Scale.
Results
Our findings showed moderate to severe parieto-temporal perfusion deficits, mild to moderate parieto-fronto-temporal perfusion deficits or borderline perfusion deficits in all but one patient.
Conclusion
Our results showed alteration in rCBF at the beginning of the illness that indicate a biological market of psychotic disorder.
Disclosure of interest
The authors have not supplied their declaration of competing interest.
The aim of this review paper is to review the data on tea tree (Melaleuca alternifolia) as an antimicrobial, antioxidant and acaricidal in poultry production. Tea tree exhibits a wide spectrum of antimicrobial activities with minimal inhibitory concentrations between 0.12 and 4 mg/ml. Its modes of action against Gram-negative bacterium Escherichia coli (0.12 to 1.5 mg/ml), Gram-positive bacterium Staphylococcus aureus (0.12 to 1 mg/ml), Aspergillus fumigatus (1.78 mg/ml) and yeast, Candida albicans (0.05 to 0.5 mg/ml) have been investigated using a range of different methods. As an antimicrobial, tea tree has high antifungal, bacteriostatic and germicidal activity (e.g. a decrease of 73.8% in Candida sp.), because of its components such as terpinen-4-ol, α-terpineol, linalool, α-pinene, β-pinene, β-myrcene and 1,8-cineole. Its bioactive compounds such as α-terpinene, α-terpinolene and γ-terpinene show high antioxidant activity when applied in concentrations of 100 and 200 µl/ml, while its essential oils demonstrated free radical scavenging activity of 60 to 80%. Tea trees insecticidal and acaricidal properties have been tested for tick control. The mortality of ticks (Ixodes ricinus) and poultry red mites (Dermanyssus gallinae) have been recorded at levels over 60% and 80%, respectively, when used in concentrations of 0.15 to 0.30 mg/cm2 during in vitro testing, and in vivo, when sprayed in poultry houses. When tea tree was used in a form of essential oils as a dietary supplement in concentrations of 50 to 150 mg/kg in broiler chicken diets, a significant increase in daily weight (by around 7%) and decrease in morbidity and mortality were seen. Additionally, when applied in laying hen nutrition, a significant increase in daily egg production has been recorded. Tea tree essential oils when supplemented in poultry diets have high positive effects regarding productivity performance, but this requires further field experiments to clarify standardisation of the material and effective inclusion levels.
The development of laser wakefield accelerators (LWFA) over the past several years has led to an interest in very compact sources of X-ray radiation – such as “table-top” free electron lasers. However, the use of conventional undulators using permanent magnets also implies system sizes which are large. In this work, we assess the possibilities for the use of novel mini-undulators in conjunction with a LWFA so that the dimensions of the undulator become comparable with the acceleration distances for LWFA experiments (i.e., centimeters). The use of a prototype undulator using laser machining of permanent magnets for this application is described and the emission characteristics and limitations of such a system are determined. Preliminary electron propagation and X-ray emission measurements are taken with a LWFA electron beam at the University of Michigan.
In order to compare estimates by one assessment scale across various cultures/ethnic groups, an important aspect that needs to be demonstrated is that its construct across these groups is invariant when measured using a similar and simultaneous approach (i.e., demonstrated cross-cultural measurement invariance). One of the methods for evaluating measurement invariance is testing for differential item functioning (DIF), which assesses whether different groups respond differently to particular items. The aim of this study was to evaluate the cross-cultural measurement invariance of the Revised Child Anxiety and Depression Scale (RCADS) in societies with different socioeconomic, cultural, and religious backgrounds.
Methods.
The study was organised by the International Child Mental Health Study Group. Self-reported data were collected from adolescents residing in 11 countries: Brazil, Bulgaria, Croatia, Indonesia, Montenegro, Nigeria, Palestinian Territories, the Philippines, Portugal, Romania and Serbia. The multiple-indicators multiple-causes model was used to test the RCADS items for DIF across the countries.
Results.
Ten items exhibited DIF considering all cross-country comparisons. Only one or two items were flagged with DIF in the head-to-head comparisons, while there were three to five items flagged with DIF, when one country was compared with the others. Even with all cross-culturally non-invariant items removed from nine language versions tested, the original factor model representing six anxiety and depressive symptoms subscales was not significantly violated.
Conclusions.
There is clear evidence that relatively small number of the RCADS items is non-invariant, especially when comparing two different cultural/ethnic groups, which indicates on its sound cross-cultural validity and suitability for cross-cultural comparisons in adolescent anxiety and depressive symptoms.
The mechanism behind the beneficial effects of enteral nutrition (EN) for patients with acute pancreatitis (AP) is largely unknown. Adipokines, as mediators of metabolism and inflammation, may be a possible mechanism. The study aimed to investigate the effect of EN on adipokines early in the course of AP. Patients with AP were randomised to EN or nil-by-mouth (NBM). Blood samples were taken on the first 4 d of admission and adipokine concentrations for adiponectin, leptin, omentin, resistin and visfatin were determined by ELISA assays. A linear mixed model analysis was run to determine differences in adipokine concentrations between the two study groups. A total of thirty-two patients were included in the study. Omentin concentrations were significantly higher in patients who received EN compared with NBM across the first 4 d of admission (mean difference: 11·6 (95 % CI 1·0, 22·3) ng/ml; P = 0·033). Leptin concentrations were significantly higher in patients who received EN compared with NBM after adjusting for age, sex and BMI (mean difference: 2·3 (95 % CI 0·1, 4·5) ng/ml; P = 0·037). No significant difference in adiponectin, resistin or visfatin concentrations were observed between the two study groups. EN significantly increases omentin and leptin concentrations in AP. Future research should be directed towards understanding whether these adipokines are responsible for the therapeutic benefits of EN.
This study evaluated the measurement invariance of the strengths and difficulties questionnaire (SDQ) self-report among adolescents from seven different nations.
Methods.
Data for 2367 adolescents, aged 13–18 years, from India, Indonesia, Nigeria, Serbia, Turkey, Bulgaria and Croatia were available for a series of factor analyses.
Results.
The five-factor model including original SDQ scales emotional symptoms, conduct problems, hyperactivity–inattention problems, peer problems and prosocial behaviour generated inadequate fit degree in all countries. A bifactor model with three factors (i.e., externalising, internalising and prosocial) and one general problem factor yielded adequate degree of fit in India, Nigeria, Turkey and Croatia. The prosocial behaviour, emotional symptoms and conduct problems factor were found to be common for all nations. However, originally proposed items loaded saliently on other factors besides the proposed ones or only some of them corresponded to proposed factors in all seven countries.
Conclusions.
Due to the lack of a common acceptable model across all countries, namely the same numbers of factors (i.e., dimensional invariance), it was not possible to perform the metric and scalar invariance test, what indicates that the SDQ self-report models tested lack appropriate measurement invariance across adolescents from these seven nations and it needs to be revised for cross-country comparisons.
Understanding crystal orientation at the ferroelectric domain level, using a non destructive technique, is crucial for the design and characterization of nano-scale devices. In this study, piezoresponse force spectroscopy (PFS) is used to identify ferroelectric domain orientation. The impact of crystal orientation on the switching field of ferroelectric BaTiO3 is also investigated at the domain level. The preferential domain orientations for BaTiO3 thin films prepared by pulsed laser deposition (PLD) in this study are [001], [101] and [111]. They have been mapped onto PFS spectra to show three corresponding switching fields of 460, 330 and 120 kV/cm respectively. In addition, the electric field at which the enhanced piezoresponse occurs was found to vary, due to a phase change. The polarization reversal occurs via a 2-step process (rotation and switching) for [101] and [111] orientations. The piezoresponse enhancement is absent for the [001] (pure switching) domains. The results demonstrate that an electric field induced phase change causes the [101] and [111] domains to reverse polarization at a lower field than the [001] domain.
The VLTI (Very Large Telescope Interferometer) makes available milli-arcsecond-scale observations in the infrared. It offers new possibilities for constraining stellar structures such as polar jets, equatorial disks and rotationally-flattened photospheres of Be stars. Such constraints allows us to better estimate the stellar fundamental parameters and refine the mechanisms such as mass loss, pulsation and magnetism that govern the variability and evolution of these stars.
In this paper we present a chromatic semi-analytical model of fast rotators, which allows us to study the dynamics and the interaction between the photosphere and the wind of fast rotating stars of O, B, A and F spectral types. Our simple analytical model addresses the oblateness, inclination and position angle of the rotation axis of the star. It produces iso-velocity maps and intensity maps. It includes line profiles, limb-darkening and the von Zeipel effect and the non-radial pulsations.
SCIROCCO+: Simulation Code of Interferometric-observations for ROtators and CirCumstellar Objects including Non-Radial Pulsations, includes all the parameters cited above in order to be fast, powerful and light simulation tool in high angular resolution of rotating objects.
In this research, we performed experimental investigations of the influence of copper presence on hardness of arsenic triselenide (As2Se3)–arsenic triiodide (AsI3) pseudobinary glasses. The samples belong to the group of chalcogenide glasses, that, when compared with oxide glasses, can be synthesized much more easily in a wide variety of compositions, allowing also fine-tuning of their properties. Here, presence of iodine (I) facilitates glass formation, whereas addition of copper (Cu) creates possibility for interesting optoelectronic properties. As it is important to study mechanical properties of materials with respect to their fabrication and manipulation, we report results of instrumented indentation testing (IIT) of bulk samples of Cux[(As2Se3)0.9(AsI3)0.1]100−x with x = 5, 10, 20, and 25 at.% of Cu. This technique enables fast determination of indentation hardness, hardness value according to Vickers and indentation modulus directly from the indentation load–displacement curves. It was shown that all these parameters increase linearly with the increase of copper content. Improvement of the mechanical properties justifies the addition of Cu into the glass matrix.
We shall begin with two stories of the October Revolution, as recalled by Russian musicians then at the peak of their careers. The first was provided by Fyodor Chaliapin, who was on stage as King Philip II in a performance of Don Carlos at the moment when a great thunderclap threw singers and audience alike into disarray. As all present later understood, this was the shot fired by the battleship Aurora, the designated signal for the insurrection to begin. Reliving the moment, Chaliapin reports:
From the cathedral steps, I see that my people have lost their nerve. The third and fourth shots, one after another. My square began to empty. Choir members and extras started moving towards the wings and, forgetting about the heretics, began to discuss which way they should run. The Spanish king, Philip II, had much trouble persuading his timid subjects that there was nowhere to run, since it was quite impossible to determine where the shells might fall. After a minute, several people came in from outside the theatre, and told us that the shells are flying in the opposite direction and we have nothing to fear. We remained on stage and the action continued. The audience also stayed put, not knowing where to run either and deciding to remain in their seats. […] By the end of the performance, the guns had fallen silent […]
Cerianite-(Ce), ideally CeO2, occurs as rounded grains up to 5 μm across in a block of highly altered calcite carbonatite lava from the Kerimasi volcano, and as euhedral crystals up to 200 μm across in carbonatite-derived eluvial deposits in the Kisete and Loluni explosion craters in the Gregory Rift, northern Tanzania. X-ray powder diffraction data (a = 5.434(5) Å) and Raman spectroscopy (minor vibration modes at 184 and 571 cm—1 in addition to a strong signal at 449 cm—1) suggest the presence of essential amounts of large cations and oxygen vacancies in the Kisete material. Microprobe analyses reveal that the mineral contains both light and heavy trivalent rare earth elements (REE) (7.9-15.5 wt.% LREE2O3 and 4.9-9.7 wt.% HREE2O3), and that it is enriched in yttrium (7.1 — 14.5 wt.% Y2O3) and fluorine (2.2—3.5 wt.%). Single-crystal structure refinement of the mineral confirms a fluorite-type structure with a cation—anion distance of 2.3471(6) Å. The cerianite-(Ce) is considered to be a late-stage secondary mineral in the carbonatitic rocks.
We finish the proof of the main structure theorems for a Chevalley group G(Φ, R) of rank ≥ 2 over an arbitrary commutative ring R. Namely, we prove that for any admissible pair (A, B) in the sense of Abe, the corresponding relative elementary group E(Φ,R, A, B) and the full congruence subgroup C(Φ, R, A, B) are normal in G(Φ, R) itself, and not just normalised by the elementary group E(Φ, R) and that [E (Φ, R), C(Φ, R, A, B)] = E, (Φ, R, A, B). For the case Φ = F4 these results are new. The proof is new also for other cases, since we explicitly define C (Φ, R, A, B) by congruences in the adjoint representation of G (Φ, R) and give several equivalent characterisations of that group and use these characterisations in our proof.
The paper presents experimental investigation of flow of dusty plasma medium formed by macroparticles in argon plasma. The dependences of the coefficient of shear viscosity of such liquid on the external force causing the flow of dusty plasma liquid and on the pressure of plasma-generating gas are studied. It is found that the viscosity of the dusty plasma medium decreases with increasing shear stress and increases with increasing pressure of buffer gas. An experimental investigation of the dynamics of macroparticles in an unperturbed liquid dusty plasma medium as a function of coupling parameter is performed; in so doing, formations of particles whose motion is correlated are observed in the region of high values of coupling parameter. It is assumed that the non-Newtonian pattern of dusty plasma liquid may be due to the emergence of crystal-like dusty plasma clusters in the ‘liquid’ phase. An experimental investigation of a crystalline dusty plasma structure under the effect of laser radiation is performed; in so doing, a macroscopic flow of the crystalline dusty plasma structure is observed under the effect of shear stress. The mechanism of formation and subsequent annihilation of edge misfit dislocations is observed and the threshold pattern of such flow is established; the threshold value of power of laser radiation is determined.
Site studies have proved Dome C to be an excellent site for optical interferometry, maybe the only possible site on Earth for the deployement of a large post-VLTI interferometric facility, like KEOPS. Indeed, recent studies have shown the possiblity of interferometric observations of faint objects, high sensitivity and high precision observations, direct imaging and nulling interferometry. However the achievement of this ambitious project assumes the pavement of a roadmap, including different steps. The first one should be a demonstrator, called Mykerinos. Mykerinos is a diluted aperture interferometer composed of at least two light collecting units with a baseline between 40 to 100 m (or more) consisting of 50 cm diameter telescopes. The telescope design is directly derived from our Laboratory's experience in the ASTEP experiment. Mykerinos will be equipped with a dual field focal instrument which is a pre-requisite for its site testing, as well as for its science demonstration purposes.
Response and remission defined by cut-off values on the last observed depression severity score are commonly used as outcome criteria in clinical trials, but ignore the time course of symptomatic change and may lead to inefficient analyses. We explore alternative categorization of outcome by naturally occurring trajectories of symptom change.
Method
Growth mixture models were applied to repeated measurements of depression severity in 807 participants with major depression treated for 12 weeks with escitalopram or nortriptyline in the part-randomized Genome-based Therapeutic Drugs for Depression study. Latent trajectory classes were validated as outcomes in drug efficacy comparison and pharmacogenetic analyses.
Results
The final two-piece growth mixture model categorized participants into a majority (75%) following a gradual improvement trajectory and the remainder following a trajectory with rapid initial improvement. The rapid improvement trajectory was over-represented among nortriptyline-treated participants and showed an antidepressant-specific pattern of pharmacogenetic associations. In contrast, conventional response and remission favoured escitalopram and produced chance results in pharmacogenetic analyses. Controlling for drop-out reduced drug differences on response and remission but did not affect latent trajectory results.
Conclusions
Latent trajectory mixture models capture heterogeneity in the development of clinical response after the initiation of antidepressants and provide an outcome that is distinct from traditional endpoint measures. It differentiates between antidepressants with different modes of action and is robust against bias due to differential discontinuation.
The ability of electron microscopes to analyze all the atoms in individual nanostructures is limited by lens aberrations. However, recent advances in aberration-correcting electron optics have led to greatly enhanced instrument performance and new techniques of electron microscopy. The development of an ultrastable electron microscope with aberration-correcting optics and a monochromated high-brightness source has significantly improved instrument resolution and contrast. In the present work, we report information transfer beyond 50 pm and show images of single gold atoms with a signal-to-noise ratio as large as 10. The instrument's new capabilities were exploited to detect a buried Σ3 {112} grain boundary and observe the dynamic arrangements of single atoms and atom pairs with sub-angstrom resolution. These results mark an important step toward meeting the challenge of determining the three-dimensional atomic-scale structure of nanomaterials.
The aim was to study the effect of twin gestations in a uterus with 2 bodies on the probability of breech presentation at delivery. The hypothesis was that the probability of breech presentation was not higher than 50%. A review was undertaken of MEDLINE (1966–2004) and of the article reference list for statistical analysis of presentation at delivery among twins in a normal uterus, singleton gestations in a uterus with 2 bodies, and case studies of twins in a uterus with 2 bodies. There are 10 studies of twin gestations in a normal uterus (Twin A 3036 cases, breech presentation 22.36%; Twin B 2758 cases, breech presentation 36.87%), 2 studies of singleton gestations in a uterus with 2 bodies (297 cases, breech presentation 42.09%), and 57 case report studies of twin gestations in a uterus with 2 bodies (Twin A 56 cases, breech presentation 14.29%; Twin B 54 cases, breech presentation 18.52%). The odds ratio and chi-square test for differences in probabilities show a significantly lower incidence of breech presentation for twins in a uterus with 2 bodies compared with twins in a normal uterus (Twin A, odds ratio = 0.58; χ2 = 2.08, p > .05, Twin B, odds ratio = 0.39, χ2 = 7.67, p < .05), and singleton gestations in a uterus with 2 bodies (Twin A, odds ratio = 0.23, χ2 = 15.51, p < .05; Twin B, odds ratio = 0.31, χ2 = 10.72, p < .05). Twin gestations in a uterus with 2 bodies decrease the probability of breech presentation.
The dielectric response of La- and Dy- doped BiFeO3 thin films at microwave frequencies (up to 12 GHz) has been monitored as a function of frequency, direct current (dc) electric field, and magnetic field in a temperature range from 25 to 300 °C. Both the real and imaginary parts of the response have been found to be non-monotonic (oscillating) functions of measuring frequency. These oscillations are not particularly sensitive to a dc electric field; however, they are substantially dampened by a magnetic field. The same effect has been observed when the volume of the characterized sample is increased. This phenomenon is attributed to the presence of a limited number of structural features with a resonance type response. The exact origin of these features is unknown at present. Leakage current investigations were performed on the whole set of films. The films were highly resistive with low leakage current, thereby giving us confidence in the microwave measurements. These typically revealed ‘N’-type I-V characteristics.
The dielectric response of La- and Dy- doped BiFeO3 thin films to electric- and magnetic fields was measured at microwave frequencies (up to 12GHz) in a temperature range from 25 °C to 300 °C. Interesting phenomena were observed. Significant oscillations in the C(f) characteristic which were unaffected by the electric field or by elevated temperature but which were dampened by a magnetic field. We also observed ‘N’-type I-V characteristics. A possible explanation for this mesoscopic response is the presence of structural features that cause resonance (e.g. grains, grain-boundaries, domains, domain walls etc), with a contribution strong enough to be averaged by the system. The exact origin of these features is unknown at present.