Shoots of naturally established, foliated red maple (Acer rubrum L.) and persimmon (Diospyros virginiana L.) growing in North Carolina were treated with 2,4-dichlorophenoxyacetic acid (2,4-D) or 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) formulations following various shoot management procedures. Shoot management prior to treatment consisted of decapitating or not decapitating shoots at 2 inches above the ground line in May when the plants were 3 to 6 ft high. Herbicidal applications were made to uncut shoots and to resprouts of previously cut shoots at 30 and 60 days after decapitation. Responses measured 10, 14, and 22 months after treatment were percent control or original shoots, percent control of new shoots, shoot height, number of live stems/plant. The original shoot and new shoot values were averaged to provide a total shoot control index. Spraying of previously cut shoots at 30 or 60 days after cutting was more effective than spraying of uncut shoots except for 2,4,5-T applied to persimmon. The average total shoot control index for 2,4-D treated red maple, considering all rates, application dates, and evaluation dates was 82% for previously cut shoots and 56% for uncut shoots while the corresponding heights were 0.9 and 4.2 ft, respectively. For 2,4,5-T-treated red maple, the total shoot control indices were 92% and 78% for previously cut and uncut shoots, respectively, while the corresponding heights were 0.4 and 1.4 ft. For persimmon, there was a net advantage for treating previously cut shoots with 2,4-D, but the reverse was true for 2,4,5-T. The results are consistent with the theoretical behavior of 2,4-D and 2,4,5-T in woody plants outlined as a basis for conducting the study. Alternate explanations of results are proposed and practical implications described.