Rotating plasmas have the potential to offer unique capabilities for isotope and mass separation. Among the various electric and magnetic field configurations offering mass separation capabilities, rotating plasmas produced through static or oscillating fields are shown to be a leading candidate for tackling the unsolved problem of large-scale plasma separation. The successful development and deployment of industrial-scale plasma separation technologies could, among many other applications, provide an innovative path towards advanced sustainable nuclear energy. In this context, the potential and versatility of plasma rotation induced by rotating magnetic fields is uncovered and analysed. Analytical stability diagrams are derived from rotating ion orbits as a function of ion mass. Based on these findings, the basic principles of a rotating field plasma separator are then introduced. In light of these results, challenges associated with this original separation process are underlined, and the main directions for a future research program aimed at this important unsolved problem of applied plasma physics are identified.