The importance of PRE herbicide applications in cotton has increased since the evolution of glyphosate-resistant (GR) Palmer amaranth. Cotton producers are relying on residual herbicides for control of Palmer amaranth, as POST options are limited or ineffective. S-Metolachlor, acetochlor, fomesafen, and dicamba all provide PRE control of Palmer amaranth; however, little is known about the effect of irrigation rate on incorporation and herbicidal efficacy. In 2015, an experiment was conducted on fine sand and loamy sand soils to evaluate the influence of irrigation volume (0.0 to 12.7 mm ha−1) on Palmer amaranth control with PRE herbicides. Irrigation volume after herbicide application was significant for both S-metolachlor and acetochlor. Efficacy of S-metolachlor was greatest in plots receiving 6.4 and 12.7 mm of irrigation where Palmer amaranth biomass was reduced to 4 and 2% of a nontreated control (NTC), respectively, compared with 61% in plots with the 0-mm irrigation treatment. Palmer amaranth control by acetochlor incorporated at 3.2- to 12.7-mm irrigation did not differ but did reduce Palmer amaranth biomass compared with the 1.6-mm irrigation rate. Irrigation volume was not significant for the soil incorporation of fomesafen or dicamba. Across all herbicides, fomesafen-treated plots provided the most consistent control of Palmer amaranth, reducing its biomass to < 3% of NTC at all irrigation rates. Dicamba provided the least and most inconsistent control of Palmer amaranth, producing 17 to 51% of NTC biomass.