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The Murchison Widefield Array (MWA) is an open access telescope dedicated to studying the low-frequency (80–300 MHz) southern sky. Since beginning operations in mid-2013, the MWA has opened a new observational window in the southern hemisphere enabling many science areas. The driving science objectives of the original design were to observe 21 cm radiation from the Epoch of Reionisation (EoR), explore the radio time domain, perform Galactic and extragalactic surveys, and monitor solar, heliospheric, and ionospheric phenomena. All together
programs recorded 20 000 h producing 146 papers to date. In 2016, the telescope underwent a major upgrade resulting in alternating compact and extended configurations. Other upgrades, including digital back-ends and a rapid-response triggering system, have been developed since the original array was commissioned. In this paper, we review the major results from the prior operation of the MWA and then discuss the new science paths enabled by the improved capabilities. We group these science opportunities by the four original science themes but also include ideas for directions outside these categories.
In vivo positron emission tomography (PET) using [C11]-labeled Pittsburgh Compound B ([C11]PiB) has previously been shown to detect amyloid-β (Aβ) in late-onset Alzheimer disease (LOAD) brain; however, the sensitivity of this technique for detecting β-amyloidosis in autosomal dominant Alzheimer disease (ADAD) has not been systematically investigated. To validate [C11]PiB PET as a useful biomarker of β-amyloidosis, we measured the cortical and regional standardized uptake value ratios (SUVRs) in 16 ADAD and 15 LOAD cases and compared them with histopathologic measures of β-amyloidosis in postmortem brain. The PiB-PET data were obtained between 40–70 min after bolus injection of ∼15 mCi of [11C]PiB. MRI and PiB-PET images were co-registered and SUVRs were generated for several brain regions. Using Aβ immunohistochemistry (10D5, Eli Lilly), the burden of Aβ plaques was quantified in 16 regions of interest using an area fraction fractionator probe (Stereo Investigator, MicroBrightfield, VT). There were regional variations in Aβ plaque burden with highest densities observed in the neocortical areas and the striatum. On spearman correlations, in vivo PiB-PET correlated with postmortem Aβ plaque burden in both LOAD and ADAD, with strongest correlations seen in neocortical areas. In summary, [C11]PiB-PET has utility as a biomarker in both ADAD and LOAD.
This presentation will enable the learner to:
1.Discuss how PET-PiB beta-amyloid imaging is used as a potential biomarker of Alzheimer disease (AD)
2.Correlate postmortem neuropathologic evidence of beta-amyloidosis with PET-PiB data, and learn that PET-PiB is a potentially useful tool to detect beta-amyloidosis in presymptomatic and symptomatic individuals
This paper updates Living with Mortality published in 2006. It describes how the longevity risk transfer market has developed over the intervening period, and, in particular, how insurance-based solutions – buy-outs, buy-ins and longevity insurance – have triumphed over capital markets solutions that were expected to dominate at the time. Some capital markets solutions – longevity-spread bonds, longevity swaps, q-forwards and tail-risk protection – have come to market, but the volume of business has been disappointingly low. The reason for this is that when market participants compare the index-based solutions of the capital markets with the customised solutions of insurance companies in terms of basis risk, credit risk, regulatory capital, collateral and liquidity, the former perform on balance less favourably despite a lower potential cost. We discuss the importance of stochastic mortality models for forecasting future longevity and examine some applications of these models, e.g. determining the longevity risk premium and estimating regulatory capital relief. The longevity risk transfer market is now beginning to recognise that there is insufficient capacity in the insurance and reinsurance industries to deal fully with demand and new solutions for attracting capital markets investors are now being examined – such as longevity-linked securities and reinsurance sidecars.
This paper describes a model of electron energization and cyclotron-maser emission applicable to astrophysical magnetized collisionless shocks. It is motivated by the work of Begelman, Ergun and Rees [Astrophys. J. 625, 51 (2005)] who argued that the cyclotron-maser instability occurs in localized magnetized collisionless shocks such as those expected in blazar jets. We report on recent research carried out to investigate electron acceleration at collisionless shocks and maser radiation associated with the accelerated electrons. We describe how electrons accelerated by lower-hybrid waves at collisionless shocks generate cyclotron-maser radiation when the accelerated electrons move into regions of stronger magnetic fields. The electrons are accelerated along the magnetic field and magnetically compressed leading to the formation of an electron velocity distribution having a horseshoe shape due to conservation of the electron magnetic moment. Under certain conditions the horseshoe electron velocity distribution function is unstable to the cyclotron-maser instability [Bingham and Cairns, Phys. Plasmas 7, 3089 (2000); Melrose, Rev. Mod. Plasma Phys. 1, 5 (2017)].
We describe the motivation and design details of the ‘Phase II’ upgrade of the Murchison Widefield Array radio telescope. The expansion doubles to 256 the number of antenna tiles deployed in the array. The new antenna tiles enhance the capabilities of the Murchison Widefield Array in several key science areas. Seventy-two of the new tiles are deployed in a regular configuration near the existing array core. These new tiles enhance the surface brightness sensitivity of the array and will improve the ability of the Murchison Widefield Array to estimate the slope of the Epoch of Reionisation power spectrum by a factor of ∼3.5. The remaining 56 tiles are deployed on long baselines, doubling the maximum baseline of the array and improving the array u, v coverage. The improved imaging capabilities will provide an order of magnitude improvement in the noise floor of Murchison Widefield Array continuum images. The upgrade retains all of the features that have underpinned the Murchison Widefield Array’s success (large field of view, snapshot image quality, and pointing agility) and boosts the scientific potential with enhanced imaging capabilities and by enabling new calibration strategies.
We present techniques developed to calibrate and correct Murchison Widefield Array low-frequency (72–300 MHz) radio observations for polarimetry. The extremely wide field-of-view, excellent instantaneous (u, v)-coverage and sensitivity to degree-scale structure that the Murchison Widefield Array provides enable instrumental calibration, removal of instrumental artefacts, and correction for ionospheric Faraday rotation through imaging techniques. With the demonstrated polarimetric capabilities of the Murchison Widefield Array, we discuss future directions for polarimetric science at low frequencies to answer outstanding questions relating to polarised source counts, source depolarisation, pulsar science, low-mass stars, exoplanets, the nature of the interstellar and intergalactic media, and the solar environment.
During the early afternoon of June 29, 2012, a line of destructive thunderstorms producing straight line winds known as a derecho developed near Chicago (Illinois, USA). The storm moved southeast with wind speeds recorded from 100 to 160 kilometers per hour (kph, 60 to 100 miles per hour [mph]). The storm swept across much of West Virginia (USA) later that evening. Power outage was substantial as an estimated 1,300,000 West Virginians (more than half) were without power in the aftermath of the storm and approximately 600,000 citizens were still without power a week later. This was one of the worst storms to strike this area and occurred as residents were enduring a prolonged heat wave. The wind damage left much of the community without electricity and the crippling effect compromised or destroyed critical infrastructure including communications, air conditioning, refrigeration, and water and sewer pumps. This report describes utilization of Emergency Medical Services (EMS) and hospital resources in West Virginia in response to the storm. Also reported is a review of the weather phenomena and the findings and discussion of the disaster and implications.
KearnsRD, WigalMS, FernandezA, TuckerMAJr, ZuidgeestGR, MillsMR, CairnsBA, CairnsCB. The 2012 Derecho: Emergency Medical Services and Hospital Response. Prehosp Disaster Med. 2014;29(5):1-4.
The increasing demand for food from limited available land, in light of declining soil fertility and future threats of climate variability and change have increased the need for more sustainable crop management systems. Conservation agriculture (CA) is based on the three principles of minimum soil disturbance, surface crop residue retention and crop rotations, and is one of the available options. In Southern Africa, CA has been intensively promoted for more than a decade to combat declining soil fertility and to stabilize crop yields. The objective of this review is to summarize recent advances in knowledge about the benefits of CA and highlight constraints to its widespread adoption within Southern Africa. Research results from Southern Africa showed that CA generally increased water infiltration, reduced soil erosion and run-off, thereby increasing available soil moisture and deeper drainage. Physical, chemical and biological soil parameters were also improved under CA in the medium to long term. CA increased crop productivity and also reduced on-farm labor, especially when direct seeding techniques and herbicides were used. As with other cropping systems, CA has constraints at both the field and farm level. Challenges to adoption in Southern Africa include the retention of sufficient crop residues, crop rotations, weed control, pest and diseases, farmer perception and economic limitations, including poorly developed markets. It was concluded that CA is not a ‘one-size-fits-all’ solution and often needs significant adaptation and flexibility when implementing it across farming systems. However, CA may potentially reduce future soil fertility decline, the effects of seasonal dry-spells and may have a large impact on food security and farmers’ livelihoods if the challenges can be overcome.
Some years ago, a group including the present author and Padma Shukla showed that a suitable non-thermal electron distribution allows the formation of ion sound solitary waves with either positive or negative density perturbations, whereas with Maxwellian electrons only a positive density perturbation is possible. The present paper discusses the qualitative features of this distribution allowing the negative waves and shared with suitable two-temperature distributions.
Significant new opportunities for astrophysics and cosmology have been identified at low radio frequencies. The Murchison Widefield Array is the first telescope in the southern hemisphere designed specifically to explore the low-frequency astronomical sky between 80 and 300 MHz with arcminute angular resolution and high survey efficiency. The telescope will enable new advances along four key science themes, including searching for redshifted 21-cm emission from the EoR in the early Universe; Galactic and extragalactic all-sky southern hemisphere surveys; time-domain astrophysics; and solar, heliospheric, and ionospheric science and space weather. The Murchison Widefield Array is located in Western Australia at the site of the planned Square Kilometre Array (SKA) low-band telescope and is the only low-frequency SKA precursor facility. In this paper, we review the performance properties of the Murchison Widefield Array and describe its primary scientific objectives.
Hydrophobic-oleophobic coatings are often used to provide the transparent electrodes in devices like touch panels and smart windows with protection from fingerprints and other contaminants which may degrade electronic and optical performance. Conventional fluorosilane monolayers or co-condensed films are often surface-enriched with fluorinated moieties due to the thermodynamic drive of these components to migrate to low-surface energy interfaces. Consequently, these conventional coatings may be strongly non-wetting and have low-surface energy when pristine, but upon wear and exposure of the bulk subsurface regions, the films are much less functional. This work explores the use of surfactant templated sol-gel silica films as scaffolds for encapsulating surface-segregating functional organic moieties as a mesoscopically dispersed phase with the goal of imparting sustained functionality. The results show that surfactant template concentration may be used to tune the dispersion of the fluorosilane-rich phase within the silica film in order to allow worn and exposed internal surfaces to maintain much of the original functionality of the pristine top surface.
A group of lawyers, psychiatrists, best interest assessors and independent mental capacity advocates were asked to make binary judgements about whether real-life situations in 12 vignettes amounted to deprivation of liberty. Kappa coefficients were calculated to describe the level of agreement within each professional group and for the total group of professionals.
There was total agreement between all professionals about deprivation of liberty in only 1 of the 12 cases. The overall level of agreement for judgements made by all professionals was ‘slight’ (κ=0.16, P < 0.01).
There are practical difficulties involved in making reliable deprivation of liberty judgements within the Deprivation of Liberty Safeguards (DoLS) legislation. A clear interpretation of deprivation of liberty is necessary to facilitate professionals' decision-making in this area.
This paper describes some aspects of lower-hybrid wave activity in space plasmas. Lower-hybrid waves are particularly important since they can transfer energy efficiently between electrons and ions in a collisionless magnetized plasma. We consider the ‘fan’ or anomalous Doppler resonance instability driven by energetic electron tails and show that it is responsible for the generation of lower-hybrid waves. We also demonstrate that observations of their intensity are sufficient to drive the modulational instability.
Amplification of a short laser pulse by means of its interaction with a counter-propagating long pulse in a plasma has been suggested as a way of reaching high intensities. Two regimes have been discussed in the literature. The first is the Raman regime, where the process is backward Raman scattering, described by the standard equations for resonant three-wave coupling, while the second is the Compton regime, in which electron dynamics is dominated by the ponderomotive force generated by the high-frequency wave, and electrons behave as single particles rather than producing a Langmuir wave. Our aim here is to use a simple model of electron dynamics to investigate the transition between these regimes.
We consider the Raman back-scatter instability produced by an electromagnetic wave in a plasma whose density increases in the direction of propagation. It is shown that, when reflexion of the waves involved in the interaction is taken into account, it may be possible to obtain, in the linear approximation, normal modes that grow exponentially in time. This is in contrast to the theory that neglects refiexion, and focuses attention only on the region of resonant interaction, which predicts only spatial amplification.
Any ion distribution f;i =(θ—ώit) is an exact solution of the Vlasov equation for a uniformly magnetized plasma. Here θ is the phase angle in velocity space and ώi is the Larmor frequency. Then fi rotates rigidly in velocity space with frequency ώ;i about an axis along a magnetic field line. If fi has anisotropy in the perpendicular velocity plane of the form fi(V, t) = fi(V) [1+A cos 2(θ— ώit)], then it represents a density modulation of frequency 2ώ;i which is confined to velocity space. This non-Maxwellian distribution is an oscillating source of free energy (a pump) which may stimulate certain ion Bernstein modes, their frequencies being near harmonics of Ωi. We here investigate the linear kinetic theory of the system. Linearization implies the parametric approximation of a strong constant pump. Application of the theory may be found in the earth's bow shock.
Magnetosonic solitons may be given smooth increasing profiles by assuming the presence within the wave of a current distribution Jy(x) of trapped ions perpendicular to Bz(x) and the wave velocity Vx. Suitable ions are found immediately upstream of perpendicular, collisionless shock waves and these are coincident with the often observed ‘foot’ in magnetic field profiles of moderately supercritical shocks. By modelling Jy(x) we apply the theory to previous experiments where Jy(x) is observed, and are able to reproduce reasonably, and thus explain, the profiles in the foot. Insight into a number of features of fast shocks is obtained.
We examine stimulated Raman scattering in an inhomogeneous plasma, and demonstrate that there may be an exponentially growing decay, which owes its existence to reflexion of the electromagnetic decay wave. Unlike absolute instabilities, which depend on simultaneous vanishing of the wavenumber mismatch and its derivative, it can occur over a wide spectrum of decay wave frequencies, and may, therefore, be of greater practical importance than those instabilities.