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Water cultures were significantly more sensitive than concurrently collected swab cultures (n=2,147 each) in detecting Legionella pneumophila within a Veterans Affairs healthcare system. Sensitivity for water versus swab cultures was 90% versus 30% overall, 83% versus 48% during a nosocomial Legionnaires’ disease outbreak, and 93% versus 22% post outbreak.
Children who grow up in poverty are more likely to experience chronic stressors that generate “wear” on stress regulatory systems including the hypothalamus–pituitary–adrenal (HPA) axis. This can have long-term consequences for health and well-being. Prior research has examined the role of proximal family and home contributions to HPA axis functioning. However, there is evidence to suggest that more distal levels of context, including neighborhoods, also matter. Prior evidence has primarily focused on adolescents and adults, with little evidence linking the neighborhood context with HPA activity in infancy and toddlerhood. We tested whether neighborhood disadvantage (indexed by US Census data) was associated with basal salivary cortisol levels at 7, 15, and 24 months of child age in a large sample of families (N = 1,292) residing in predominately low-income and rural communities in the United States. Multilevel models indicated that neighborhood disadvantage was positively associated with salivary cortisol levels and that this effect emerged across time. This effect was moderated by the race/ethnicity of children such that the association was only observed in White children in our sample. Findings provide preliminary evidence that the neighborhood context is associated with stress regulation during toddlerhood, elucidating a need for future work to address possible mechanisms.
Humanity has long been fascinated by the planet Mars. Was its climate ever conducive to life? What is the atmosphere like today and why did it change so dramatically over time? Eleven spacecraft have successfully flown to Mars since the Viking mission of the 1970s and early 1980s. These orbiters, landers and rovers have generated vast amounts of data that now span a Martian decade (roughly eighteen years). This new volume brings together the many new ideas about the atmosphere and climate system that have emerged, including the complex interplay of the volatile and dust cycles, the atmosphere-surface interactions that connect them over time, and the diversity of the planet's environment and its complex history. Including tutorials and explanations of complicated ideas, students, researchers and non-specialists alike are able to use this resource to gain a thorough and up-to-date understanding of this most Earth-like of planetary neighbours.
Conner et al. have reported the sudden emergence of a strong X-ray source at 3-12 keV in a position well removed from any previously known X-ray source. This source has been confirmed by Kitamura et al. We wish to report the results of an attempt to detect the source during a balloon flight made from Mildura, Australia, on 1969 August 25.
The segregation behavior of model dopants during liquid phase epitaxy of A/A1−xBx heterostructures is studied using Non-equilibrium Molecular Dynamics computer simulation. Interatomic interactions are modelled using the Lennard-Jones potential and the dopant “B” atoms are assigned to have a different diameter than the host “A” atoms. The extent of segregation as a function of regrowth velocity is found to be well represented by the Continuous Growth Model of Aziz for solidification on the (111) orientation. The mechanism of segregation, however, more closely resembles the physical picture due to Jackson, Gilmer and Leamy.
A novel method of fabricating low-density hollow sphere metallic foam has been developed. Utilizing pre-existing technology, thin-wall, hollow oxide spheres, ∼ 2mm in diameter, were formed from powder slurries with a coaxial nozzle process. Oxide foams were constructed by bonding sintered spheres at points of contact and firing. The oxide foams were reduced to the metallic state in a hydrogen atmosphere. Successful precursor compositions for transformation included NiO, Cu2O, and NiO-Cu2O. After reduction, the metal foams were sintered to increase strength and resulting foam densities were generally 10–20% of theoretical density. Wall thickness of the spheres which constitute the foams ranged from 50–100 μ m. Nickel foams were crushed under uniaxial compressive stress, and mechanical properties (yield stress, elastic modulus, and energy absorption) were investigated under varying density in order to determine parametric relationships to compare to existing models of foam properties. The effects of sintering, reduction, and compressive deformation on the microstructures were examined with SEM and EDS.
Silicon nitride ceramics have been prepared using the fused deposition (FD) process in a Stratasys 1650 modeler. Two types of silicon nitride have been prepared: GS44 and AS800. AS800 is processed and used at higher temperatures than GS44. The strength of machined surfaces of either type of silicon nitride prepared using FD is comparable to conventionally processed material. Using standard build conditions strengths for as-built and as-sintered
surfaces are approximately 50% lower. The additive nature of solid freeform processes also allows multi-material combinations to be deposited which result in enhanced performance. For example, combinations of silicon nitride based materials with different thermal expansion coefficients have been prepared which demonstrate strength increases > 20%. In addition, components containing complicated internal cavities may also be fabricated.
The Fused Deposition of Ceramics (FDC) process is an extrusion based layered manufacturing technique. In this study, the microstructural and property homogeneity of GS44-Si3N4 parts made by FDC is examined. The feedstock, green, and sintered parts were examined using characterization techniques such as optical and scanning electron microscopy, x-ray radiography, and x-ray diffraction. In addition, mechanical properties (σf, and Klc), shrinkage, and warpage results were used to characterize the FDC parts. It was found that by using proper build parameters and tool paths, dense, homogenous, near-net-shape GS44-Si3N4 parts can be fabricated. While the mechanical properties of these parts are shown to be isotropic, there is some degree of texturing detected with XRD. Si3N4 filament feedstock intentionally textured with 5.5 vol% of β-seed particles has also been made.
Microcephaly is a marker of abnormal fetal cerebral development, and a known risk factor for cognitive dysfunction. Patients with hypoplastic left heart syndrome have been found to have an increased incidence of abnormal neurodevelopmental outcomes. We hypothesized that reduced cerebral blood flow from the diminutive ascending aorta and transverse aortic arch in the setting of hypoplastic left heart syndrome may influence fetal growth of the brain. The purpose of our study, therefore, was to define the prevalence of microcephaly in full-term infants with hypoplastic left heart syndrome, and to investigate potential cardiac risk factors for microcephaly. We carried out a retrospective review of full-term neonates with hypoplastic left heart syndrome. Eligible patients had documented indexes of birth weight, and measurements of length, and head circumference, as well as adequate echocardiographic images for measurement of the diameters of the ascending aorta and transverse aortic arch. We used logistic regression for analysis of the data. A total of 129 neonates met the criterions for inclusion, with 15 (12%) proving to have microcephaly. The sizes of their heads were disproportionately smaller than their weights (p less than 0.001) and lengths (p less than 0.001) at birth. Microcephaly was associated with lower birth weight (p less than 0.001), lower birth length (p equal to 0.007), and a smaller diameter of the ascending aorta (p equal to 0.034), but not a smaller transverse aortic arch (p equal to 0.619), or aortic atresia (p equal to 0.969). We conclude that microcephaly was common in this cohort of neonates with hypoplastic left heart syndrome, with the size of the head being disproportionately smaller than weight and length at birth. Microcephaly was associated with a small ascending aorta, but not a small transverse aortic arch. Impairment of somatic growth may be an additional factor in the development of microcephaly in these neonates.