Ten herbicides were evaluated for broomrape (Orobanche ramosa L. # ORARA) control and their effect on growth, yield, and chemical composition of four tobacco (Nicotiana tabaccum L.) cultivars. Of the preplant-incorporated (PPI) herbicides, only pebulate (S-propyl butylethylcarbamothioate) at 7.2 kg ai/ha and metham (methylcarbamodithioic acid) at 66 kg ai/ha provided, although inconsistently, 30 to 50% broomrape control in oriental but not in burley tobacco. Single postemergence (POE) applications of glyphosate [N-(phosphonomethyl)glycine] at 0.2 kg ai/ha or MH (1,2-dihydro-3,6-pyridazinedione) at 0.7 kg ai/ha at 40 days after transplanting resulted in 60 to 80% broomrape control. Glyphosate or MH applications at 40 days after transplanting and again at 60 days resulted in 100% and 80 to 90% control, respectively. Very good (80 to 90%) control also occurred with pebulate (PPI) at 7.2 kg ai/ha followed by glyphosate (POE) at 0.2 kg ai/ha at 40 days after transplanting. Tobacco yield increased significantly, compared to that of untreated plots, where glyphosate or MH was used, but nicotine, total nitrogen, and reducing sugar contents were not significantly affected.