This paper argues for a new way of thinking about Early Celtic art in the context of changes taking place throughout Eurasia during the fifth and fourth centuries bce. It applies ideas of anthropologist Alfred Gell, among others, regarding art as a stimulus to action. It asks, in the spirit of papers by Chris Gosden and W.J.T. Mitchell, ‘what did the art do’? The paper argues that this complex new art can be understood in terms of agency contributing to and even stimulating aggressive attitudes and practices on the part of elites during the late fifth and early fourth centuries bce. The new worldviews that are apparent in the new style, and actions driven by them, played major roles in Iron Age Europeans’ participation in the so-called Axial Age of dynamic change throughout Eurasia.

Humans have been producing ‘art’ for at least 75,000 years. But the word ‘art’ is problematic when applied to archaeology. This paper explores the use of the concept of ‘visually complex object’ to designate a very specific kind of what is generally known as ‘art’. I argue for the application of this concept to the analysis of both the design of objects and their arrangement in cultural spaces, to gain new perspectives on social and political change in a prehistoric complex society. The focus here is on visually enchanting objects and changes in the ways that such objects were used and arranged in relation to larger changes in cultural circumstances. I contrast two visual orders in Iron Age Europe—the mid final millennium bc, when the visual order of ‘princely graves’ and the eye-fixing qualities of objects focused attention on the persons of individuals competing for leadership positions; and the second and final centuries bc, when a new visual order emerged to focus attention on large, publicly deployed objects that directed attention in open spaces to create collective experiences. The principles developed from these examples from late prehistoric Europe can be applied to changes in other complex societies worldwide.

Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is balanced to maximise absorptive capacity, while maintaining efficient defensive reactions against chemical and microbial challenges. Evidence is mounting that disruption of epithelial barrier integrity is one of the major aetiological factors associated with several gastrointestinal diseases, including infection by pathogens, obesity and diabetes, necrotising enterocolitis, irritable bowel syndrome and inflammatory bowel disease. The notion that specific probiotic bacterial strains can affect barrier integrity fuelled research in which in vitro cell lines, animal models and clinical trials are used to assess whether probiotics can revert the diseased state back to homeostasis and health. This review catalogues and categorises the lines of evidence available in literature for the role of probiotics in epithelial integrity and, consequently, their beneficial effect for the reduction of gastrointestinal disease symptoms.

Large volume fractions of Mn–Ni–Si (MNS) precipitates formed in irradiated light water reactor pressure vessel (RPV) steels cause severe hardening and embrittlement at high neutron fluence. A new equilibrium thermodynamic model was developed based on the CALculation of PHAse Diagrams (CALPHAD) method using both commercial (TCAL2) and specially assembled databases to predict precipitation of these phases. Good agreement between the model predictions and experimental data suggest that equilibrium thermodynamic models provide a basis to predict terminal MNS precipitation over wider range of alloy compositions and temperatures, and can also serve as a foundation for kinetic modeling of precipitate evolution.