The U.S. Department of Veterans Affairs is actively transitioning away from a disease-centric model of healthcare to one that prioritizes disease prevention and the promotion of overall health and well-being. Described as Whole Health, this initiative aims to provide personalized, values-centered care that optimizes physical, behavioral, spiritual, and socioeconomic well-being. To inform this initiative, we analyzed cross-sectional data from a nationally representative sample of primarily older U.S. military veterans to estimate levels of well-being across these domains, and identify sociodemographic, military, and potentially modifiable health and psychosocial correlates of them. Results revealed that, overall, veterans reported high domain-specific well-being (average scores ranging from 6.7 to 8.3 out of 10), with the highest levels in the socioeconomic domain and lowest in the physical domain. Several modifiable factors, including purpose in life, resilience, and social support, were strongly associated with the examined well-being domains. Interventions targeting these constructs may help promote well-being among U.S. veterans.

The influence of Cu(II) on the hydrothermal and thermal transformations of a synthetic hectorite was investigated by a combined approach using mainly X-ray diffraction, thermal analyses, and electron paramagnetic resonance spectroscopy. The presence of Cu(II) during hydrothermal treatment increased the crystallite size. Copper (II) was both structure-bound and associated with the inner surfaces of the particles. Upon heating, structural destabilization of the hectorite began at ∼400°C as indicated by the formation of free radicals. Between 600 and 700°C, the hectorite converted to enstatite, and in the presence of Cu(II), to enstatite and richterite. The formation of richterite as an additional conversion product is explained by the creation of structural weakness due to structure-bound Cu(II) in F-containing hectorite. Our results suggest that traces of Cu(II), typical of natural environments, may influence the conversion products in high-temperature geochemical systems.

This systematic literature review aimed to provide an overview of the characteristics and methods used in studies applying the disability-adjusted life years (DALY) concept for infectious diseases within European Union (EU)/European Economic Area (EEA)/European Free Trade Association (EFTA) countries and the United Kingdom. Electronic databases and grey literature were searched for articles reporting the assessment of DALY and its components. We considered studies in which researchers performed DALY calculations using primary epidemiological data input sources. We screened 3053 studies of which 2948 were excluded and 105 studies met our inclusion criteria. Of these studies, 22 were multi-country and 83 were single-country studies, of which 46 were from the Netherlands. Food- and water-borne diseases were the most frequently studied infectious diseases. Between 2015 and 2022, the number of burden of infectious disease studies was 1.6 times higher compared to that published between 2000 and 2014. Almost all studies (97%) estimated DALYs based on the incidence- and pathogen-based approach and without social weighting functions; however, there was less methodological consensus with regards to the disability weights and life tables that were applied. The number of burden of infectious disease studies undertaken across Europe has increased over time. Development and use of guidelines will promote performing burden of infectious disease studies and facilitate comparability of the results.

The last meal of Tollund Man, a bog body from Early Iron Age Denmark, has been re-examined using new analyses of plant macrofossils, pollen, non-pollen palynomorphs, steroid markers and proteins found in his gut. Some 12–24 hours before he was killed, he ate a porridge containing barley, pale persicaria and flax, and probably some fish. Proteins and eggs from intestinal worms indicate that he was infected with parasites. Although the meal may reflect ordinary Iron Age fare, the inclusion of threshing waste could possibly relate to ritual practices. This re-analysis illustrates that new techniques can throw fresh light on old questions and contribute to understanding life and death in the Danish Early Iron Age.

The 1717 Christmas flood is one of the most catastrophic storm surges the Frisian coast (Netherlands and Germany) has ever experienced. With more than 13,700 casualties it is the last severe storm surge with a death toll of this order. At the same time, little is known about the hydrodynamic conditions and the morphological effects associated with this storm surge.

In this study, 41 potential dyke failures in the Province of Groningen (Netherlands) associated with the 1717 Christmas flood were systematically reconstructed and mapped by using historical maps and literature and by analysing the recent topography in search of typical pothole structures and sediment fans. The dimensions of the sediment fans as derived from the topography show a good accordance with the dimensions documented by vibracore profiles, direct push tests and electrical resistivity tomography data taken at three fieldwork sites. Moreover, the fan dimensions closely agree with the dimensions as simulated using a process-based morphodynamic numerical model for one of the three sites, the village of Wierhuizen. Consequently, the recent topography is still indicative for the locations and dimensions of dyke failures and sediment fans associated with the 1717 Christmas flood. Considering the large number of detected dyke failures (41) and the large dimensions of the potholes and particularly of the sediment fans up to a few hundred metres wide and up to 0.7 m thick, this study proves significant morphological effects of the 1717 Christmas flood on the mainland of the Province of Groningen.

Based on the numerical simulation approach and the comparison with field data and field observations, a maximum seaward water level of 5 m NAP for the dyke failure at Wierhuizen during the Christmas flood can be derived. A similar maximum water level is indicated for the two other fieldwork sites Vierhuizen and Kohol, which is in good agreement with the maximum storm surge level of 4.62 m NAP historically documented for the city of Emden located almost 50 km to the east of Wierhuizen.

The results of the current study demonstrate that the reconstruction of historical dyke failures based on (i) historical sources, (ii) recent lidar/high-resolution topographical data, (iii) multi-proxy sedimentary field data and (iv) hydro- and morphodynamic numerical simulations is a highly promising approach to derive hydrodynamic conditions and the morphological onshore response of the 1717 Christmas flood in the Province of Groningen. This knowledge is essential to improve our understanding of extreme storm surge dynamics, their influence on the coastal landscape and the associated hazards for the coastal population.

Hala Sultan Tekke is a large Bronze Age city located on the southeastern littoral of Cyprus. The city flourished from approximately 1650 BC to 1150 BC according to the archaeological evidence. Since 2010, Swedish excavations have exposed four new city quarters (CQ1–4) with three occupational phases, the 14C dating of which is of highest importance also for other contemporaneous cultures. The finds demonstrate vast intercultural connections in the Mediterranean and even with southern Scandinavia. In 2014, roughly 500 m to the east of CQ1, one of the richest cemeteries on the island was discovered. According to the archaeological evidence, the finds from the city date mainly to the 13th and 12th centuries BC. However, many of the wealthy tombs and the offering pits from the cemetery are considerably older with the oldest finds dating to the 16th century BC. This raises the question where the city quarters belonging to the oldest finds from the cemetery are situated. The radiocarbon (14C) dates from Hala Sultan Tekke have much influence on the dating of related sites because of numerous imports from a vast area. We present here new 14C data obtained in the course of the current excavations, which add to sets of already existing data.

After five positive randomized controlled trials showed benefit of mechanical thrombectomy in the management of acute ischemic stroke with emergent large-vessel occlusion, a multi-society meeting was organized during the 17th Congress of the World Federation of Interventional and Therapeutic Neuroradiology in October 2017 in Budapest, Hungary. This multi-society meeting was dedicated to establish standards of practice in acute ischemic stroke intervention aiming for a consensus on the minimum requirements for centers providing such treatment. In an ideal situation, all patients would be treated at a center offering a full spectrum of neuroendovascular care (a level 1 center). However, for geographical reasons, some patients are unable to reach such a center in a reasonable period of time. With this in mind, the group paid special attention to define recommendations on the prerequisites of organizing stroke centers providing medical thrombectomy for acute ischemic stroke, but not for other neurovascular diseases (level 2 centers). Finally, some centers will have a stroke unit and offer intravenous thrombolysis, but not any endovascular stroke therapy (level 3 centers). Together, these level 1, 2, and 3 centers form a complete stroke system of care. The multi-society group provides recommendations and a framework for the development of medical thrombectomy services worldwide.

Thin hole transport layers are important elements in organic semiconductor-based devices. Metal oxides are an encouraging material class for this purpose, as they may provide sufficient hole conduction in combination with excellent electron blocking properties. Both, long-term device stability, which may often be limited by the thermal stability of interfaces, and higher temperature processing steps, benefit strongly from the existence of thermally stable metal oxide interlayers. Provided that thermally stable electrodes can be fashioned, the stability of organic active layers—for example, in organic field effect transistors, light emitting diodes, or photovoltaic (OPV) devices can be investigated. Here, we apply this concept and report about the study of hole mobility (µh) in single-carrier-hole-only devices in dependence of thermal annealing up to the above the actual melting temperature of regio-regular poly(3-hexylthiophene-2,5-diyl) (P3HT).

A new continuum approach to snowdrift modelling is introduced. In addition, numerical studies are carried out to identify the influence of time-varying wind conditions on snowdrift simulations. We compare the snowdrift patterns at Grimming mountain, Austria, derived using a time-averaged wind field and a time-varying wind field obtained from the numerical weather prediction model INCA. The results show significant differences in the deposition patterns and snow depth even after a 6 hour drift period. Using time-averaged boundary conditions leads to an underprediction of the resulting snow depth caused by averaging the wind speed, which lets gusts of wind disappear while snow transport is a non-linear function of the wind speed. Using numerical weather prediction models for snowdrift simulation therefore provides enhanced knowledge of the snow depth for local avalanche warning services.

Records of surface motion, englacial tilt and repeat inclinometry are used to determine patterns of surface, internal and basal motion across the tongue of Haut Glacier d’Arolla, Switzerland, over temporal scales ranging from days to months. Findings are interpreted with reference to contemporaneous measurements of subglacial water pressures, and prior knowledge of the glacier’s subglacial drainage-system structure. Long-term inclinometry results show pronounced extrusion flow over a subglacial drainage axis, with basal velocities up to twice those measured at the glacier surface. Deformation profiles are more conventional away from the drainage axis, with basal velocities ∼60–70% of surface velocities. Comparison of long-term tilt rates from repeat inclinometry and englacial tiltmeters shows close correspondence. Englacial tiltmeter data are used to reconstruct internal velocity profiles and to split surface velocities into internal deformation and basal motion contributions over spring, summer and autumn/winter periods. Although, spatial patterns of surface movement are similar between periods, patterns of internal and basal motion are not. Results are interpreted in terms of the location of sticky and slippery spots, with temporally changing patterns of basal drag reflecting changing distributions of water pressure.

Three early-melt-season high-velocity events (or “spring events”) occurred on Haut Glacier d’Arolla, Switzerland, during the melt seasons of 1998 and 1999. The events involve enhanced glacier velocity during periods of rapidly increasing bulk discharge in the proglacial stream and high subglacial water pressures. However, differences in spatial patterns of surface velocity, internal ice deformation rates, the spatial extent of high subglacial water pressures and in rates of subglacial sediment deformation suggest different hydrological and mechanical controls. The data from two of the events suggest widespread ice–bed decoupling, particularly along a subglacial drainage axis creating the highest rates of basal motion and “plug flow” in the overlying ice. The other event showed evidence of less extensive ice–bed decoupling and sliding along the drainage axis with more mechanical support for ice overburden transferred to areas adjacent to decoupled areas. We suggest that: (1) plug flow may be a common feature on glaciers experiencing locally induced reductions in basal drag; (2) under certain circumstances, enhanced surface motion may be due in part to non-locally forced enhanced bed deformation; and (3) subglacial sediment deformation is confined to a depth of the order of centimetres to decimetres.

This study uses two novel archaeobotanical techniques – crop carbon and nitrogen isotope analysis and functional weed ecology – to determine directly how the intensity of agricultural practice changed from the Neolithic to the Early Iron Age in south-west Germany, with the emergence of fortified hilltop settlements (Fürstensitze or chiefly seats) regarded as the first urban centres in central Europe. The crop isotope and functional weed ecological evidence suggest that surplus cereal production in the Early Iron Age was achieved through sustained use of manure combined with expansion in arable cultivation, both developments that are connected with more widespread use of animal traction. The increased scale of cultivation is broadly apparent across rural as well as fortified hilltop centres in the Early Iron Age, and considerable variability in manuring intensity is consistent with agricultural decision-making at a local level rather than centralised control. Additionally, the more intensive manuring of hulled six-row barley, used in beer production, demonstrates that the political importance of drinking and feasting in Early Iron Age society was reflected in crop husbandry practices. In terms of animal husbandry, faunal isotope data reveal a radical decrease in forest cover, potentially reflecting an expansion in the scale of herding accompanying that of arable cultivation. Site-specific patterning points to a range of herding strategies, from specialised herding of cattle at the Heuneburg to generalised patterns of livestock management at rural sites.

Based on presented field data, it is shown that snow contributes roughly 8% to the total mass of ice in the Weddell Sea. Snow depth averages 0.16 m on first-year ice (average thickness 0.75 m) and 0.53 m on second-year ice (average thickness 1.70 m). Due to snow loading, sea ice is depressed below water level and flooded by sea water. As a result of flooding, snow ice forms through congelation of sea water and brine in a matrix of meteoric ice (i.e. snow). Sea-ice growth has been simulated with a one-dimensional model, treating the evolution of salinity, porosity and thermal properties of the ice. Simulations demonstrate that in the presence of a snow cover, ice growth is significantly reduced. Brine volumes increase by a factor of 1.5–2, affecting properties such as ice strength. Snow-ice formation depends on the evolution of freeboard and ice permeability. Effects of accumulation-rate changes have been assessed, for the Weddell Sea with a large-scale sea-ice model accounting for snow-ice formation. Results for different scenarios are presented and compared with field data and one-dimensional simulations. The role of snow in modulating the response of Antarctic sea ice to climate change is discussed.

In order to study, in situ, the rheology of a deforming subglacial till, various instruments were emplaced in till beneath Storglaciären, Sweden. Boreholes were used to gain access to the till beneath about 100 m of ice. Tiltmeters provided an estimate of the shear strain rate in the till. Two other instruments yielded measures of till strength. In addition, water pressures were recorded in boreholes and in the till, a computer-controlled distance meter provided an effectively continuous record of the surface velocity and data from frequent surveys of a stake network were used to estimate the mean basal drag, based on a force-balance calculation.

Tilt rates varied directly with effective pressure, so decreases in water pressure apparently increased the coupling between the glacier and the bed. Surface speed was either out of phase with tilt or varied independently of tilt. Thus, increases in speed were apparently a consequence either of longitudinal coupling or of reduced coupling between the glacier and the bed; they were not a result of till deformation! Till strength varied directly with effective pressure, which is consistent with it being a Mohr – Coulomb, or frictional material. The devices measuring till strength are presumed to have been pulled through the till at a speed that varied in phase with the surface speed but till strength did not vary systematically with surface speed. This implies that the residual strength of the till is insensitive to strain rate. Thus, the appropriate constitutive equation for till rheology may be of the form:

where k is a constant. This is consistent with experimental data reported in the geotechnical literature.

Force variations on a "ploughmeter" and fluctuations in subglacial water pressure have been measured in the same borehole at Storglaciaren, Sweden, to investigate hydraulic properties of the basal till layer. A strong inverse correlation of the pressure and force records, in conjunction with a significant lime lag between the two signals, suggests that pore-water pressures directly affect the strength of the till. Variations in sub-glacial water pressure result in potential gradients across the water till interlace at the bottom of the borehole that drive pressure waves downwards through the till layer when the borehole water level is high and back upwards when the water level is low. Analysis of the propagation velocity of this pressure wave indicates that the hydraulic diffusivity of Storglaciaren till is in the range 1.9−3.6 x 10−6m2s−1,in good agreement with estimates obtained in the laboratory. Hydraulic conductivity values associated with these difrusivities are between 10−9 and 10−8ms−1 and thus are well within the range of values for other glacial tills.