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We prove that any skew-symmetrizable cluster algebra is unistructural, which is a conjecture by Assem, Schiffler and Shramchenko. As a corollary, we obtain that a cluster automorphism of a cluster algebra
is just an automorphism of the ambient field
which restricts to a permutation of the cluster variables of
For a skew-symmetrizable cluster algebra
with principal coefficients at
, we prove that each seed
is uniquely determined by its
-matrix, which was proposed by Fomin and Zelevinsky (Compos. Math. 143 (2007), 112–164) as a conjecture. Our proof is based on the fact that the positivity of cluster variables and sign coherence of
-vectors hold for
, which was actually verified in Gross et al. (Canonical bases for cluster algebras, J. Amer. Math. Soc. 31(2) (2018), 497–608). Further discussion is provided in the sign-skew-symmetric case so as to obtain a weak version of the conjecture in this general case.
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