The present study examined the contributions of mindfulness meditation practice on job burnout, a choice of stress coping styles, and job satisfaction. The online survey data were obtained from 93 meditation practitioners and 54 non-practitioners in Thailand (total n = 147). Results from partial least squares regression suggested that respondents who had regularly practiced mindfulness meditation tended to report lower burnout. In addition, they tended to adopt more problem-focused coping and less emotion-focused coping in order to deal with work-related stress. The author also found that regular mindfulness meditation practice also contributed indirectly to higher job satisfaction.