Single- and multiple-pulse laser damage thresholds of six different metal-containing acrylic polymers were determined at 10.6, 1.06, 0.53 and 0.355 μm. Light transmission of these samples before and after irradiation was measured. A variety of observed laser-materials interactions are discussed in this paper. Physical and chemical damage properties of these metal-containing acrylic polymers were examined and compared with poly (methyl methacrylate) and polycarbonate using scanning electron microscopy (SEM), infrared spectroscopy (IR), and electron spectroscopy for chemical analysis (ESCA). In general, it was found that the multiple-pulse damage thresholds were lower than the single-pulse, and damage thresholds decreased as wavelength of the testing laser beam became shorter.