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The effects of in utero exposure to atypical
antipsychotics on infant birth weight are unknown.
To determine whether atypical and typical antipsychotics differ in their
effects on birth weight after maternal exposure during pregnancy.
Prospective data on gestational age and birth weight collected by the
National Teratology Information Service for infants exposed to typical
(n=45) and atypical (n=25)
antipsychotics was compared with data for a reference group of infants
Infants exposed to atypical antipsychotics had a significantly higher
incidence of large for gestational age (LGA) than both comparison groups
and a mean birth weight significantly heavier than those exposed to
typical antipsychotics. In contrast those exposed to typical
antipsychotics had a significantly lower mean birth weight and a higher
incidence of small for gestational age infants than the reference
In utero exposure to atypical antipsychotic drugs may
increase infant birth weight and risk of LGA.
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