Field studies were conducted at Aberdeen, ID; Ontario, OR; and Paterson, WA, to evaluate potato tolerance to flumioxazin and sulfentrazone. In ‘Russet Burbank’ tolerance trials conducted in 2000 at ID, OR, and WA, sulfentrazone applied preemergence (PRE) at rates ranging from 105 to 280 g ai/ha caused significant injury consisting of stunting, leaf discoloration-blackening, and/or leaf malformation-crinkling at 4 wk after treatment (WAT). By 12 WAT, injury was ≤5%. At 4 WAT, flumioxazin applied PRE at 105 and 140 g ai/ha resulted in injury, whereas 53 g ai/ha did not cause significant injury. At 12 WAT, no visual injury was present at the ID site, whereas flumioxazin at 140 g/ha was still causing injury in WA. Regardless of initial injury, Russet Burbank tuber yields at ID, OR, and WA were not reduced as a result of any flumioxazin or sulfentrazone treatment compared with the nontreated controls. In potato variety tolerance trials conducted at ID in 2000 and at WA in 2002 with Russet Burbank, ‘Ranger Russet’, ‘Russet Norkotah’, and ‘Shepody’ and at ID in 2002 with those varieties plus ‘Alturas’ and ‘Bannock Russet’, early season injury caused by flumioxazin or sulfentrazone applied PRE at rates as high as 210 g ai/ha or 280 g/ha, respectively, occurred, but variety tuber yields were not reduced compared with nontreated control yields. In contrast, at ID in 2001, early injury caused by flumioxazin or sulfentrazone applied PRE at 105 or 210 g/ha translated to tuber yield reductions of all six varieties tested compared with the nontreated controls. At WA in 2001, Ranger Russet tuber yields were reduced by PRE applications of flumioxazin at 53 to 140 g/ha or sulfentrazone at 105 to 280 g/ha, and Shepody total tuber yields were reduced by all rates of PRE-applied sulfentrazone. Russet Burbank and Russet Norkotah tuber yields were unaffected by either herbicide. Unusual heat stress occurring early in the 2001 growing season at both locations may have compounded the effects of herbicide injury and, consequently, tuber yields were reduced in 2001, whereas injury occurring in 2000 or 2002 during relatively normal growing conditions did not translate to yield reductions.