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That almost half the Northern electorate continued to vote for Democrats is one of the worst understood aspects of the Civil War experience. In too many accounts of the war, Northern Democrats either do not figure at all, or do so only as morally blind obstructionists on the wrong side of history. Yet there is a case for saying that rather than being peripheral to the narrative of the war, Northern Democrats should be center stage. Because the route to Confederate victory lay in convincing the North that the cost of coercion was too high to be worth paying, the views and actions of that large and fluctuating group of white Northerners who had never joined the Republican bandwagon was crucial.
In patients with β-lactam allergies, administration of non–β-lactam surgical prophylaxis is associated with increased risk of infection. Although many patients self-report β-lactam allergies, most are unconfirmed or mislabeled. A quality improvement process, utilizing a structured β-lactam allergy tool, was implemented to improve the utilization of preferred β-lactam surgical prophylaxis.
Cognitive impairment is strongly linked with persistent disability in people with mood disorders, but the factors that explain cognitive impairment in this population are unclear.
To estimate the total effect of (a) bipolar disorder and (b) major depression on cognitive function, and the magnitude of the effect that is explained by potentially modifiable intermediate factors.
Cross-sectional study using baseline data from the UK Biobank cohort. Participants were categorised as having bipolar disorder (n = 2709), major depression (n = 50 975) or no mood disorder (n = 102 931 and n = 105 284). The outcomes were computerised tests of reasoning, reaction time and memory. The potential mediators were cardiometabolic disease and psychotropic medication. Analyses were informed by graphical methods and controlled for confounding using regression, propensity score-based methods and G-computation.
Group differences of small magnitude were found on a visuospatial memory test. Z-score differences for the bipolar disorder group were in the range −0.23 to −0.17 (95% CI −0.39 to −0.03) across different estimation methods, and for the major depression group they were approximately −0.07 (95% CI −0.10 to −0.03). One-quarter of the effect was mediated via psychotropic medication in the bipolar disorder group (−0.05; 95% CI −0.09 to −0.01). No evidence was found for mediation via cardiometabolic disease.
In a large community-based sample in middle to early old age, bipolar disorder and depression were associated with lower visuospatial memory performance, in part potentially due to psychotropic medication use. Mood disorders and their treatments will have increasing importance for population cognitive health as the proportion of older adults continues to grow.
Declaration of interest
I.J.D. is a UK Biobank participant. J.P.P. is a member of the UK Biobank Steering Committee.
This chapter shows that fusion in the United States, particularly under the influence of Legal Realism, has seen all of tort law become equitable – or all of tort law swallowed up by equity. Each of tort and equity has, under this influence, the potential to swallow up all of private law. The chapter shows, however, the tort law is nevertheless distinct – particularly from equity. Tort law rules are general commands simply understood and relatively simply applied. They are intended to guide the behaviour of all people. Equity, in contrast, mainly consists of second-order rules: rules that presuppose other rules, and control how those other rules work. Fusion is explored by seeing where tort law rules have been injected with second-order (equitable) rules and where equity has produced a doctrine that has become embedded in the law as a set of first-order rules. There is a case for having both first- and second-order rules in the law today.
The fusion of law and equity in common law systems was a crucial moment in the development of the modern law. Common law and equity were historically the two principal sources of rules and remedies in the judge-made law of England, and this bifurcated system travelled to other countries whose legal systems were derived from the English legal system. The division of law and equity - their fission - was a pivotal legal development and is a feature of most common law systems. The fusion of the common law and equity has brought about major structural, institutional and juridical changes within the common law tradition. In this volume, leading scholars undertake historical, comparative, doctrinal and theoretical analysis that aims to shed light on the ways in which law and equity have fused, and the ways in which they have remained distinct even in a 'post-fusion' world.
A growing interest in constellations of small satellites has recently emerged due to the increasing capability of these platforms and their reduced time and cost of development. However, in the absence of dedicated launch services for these systems, alternative methods for the deployment of these constellations must be considered which can take advantage of the availability of secondary-payload launch opportunities. Furthermore, a means of exploring the effects and tradeoffs in corresponding system architectures is required. This paper presents a methodology to integrate the deployment of constellations of small satellites into the wider design process for these systems. Using a method of design-space exploration, enhanced understanding of the tradespace is supported , whilst identification of system designs for development is enabled by the application of an optimisation process. To demonstrate the method, a simplified analysis framework and a multiobjective genetic algorithm are implemented for three mission case-studies with differing application. The first two cases, modelled on existing constellations, indicate the benefits of design-space exploration, and possible savings which could be made in cost, system mass, or deployment time. The third case, based on a proposed Earth observation nanosatellite constellation, focuses on deployment following launch using a secondary-payload opportunity and demonstrates the breadth of feasible solutions which may not be considered if only point-designs are generated by a priori analysis. These results indicate that the presented method can support the development of future constellations of small satellites by improving the knowledge of different deployment strategies available during the early design phases and through enhanced exploration and identification of promising design alternatives.
We have observed the G23 field of the Galaxy AndMass Assembly (GAMA) survey using the Australian Square Kilometre Array Pathfinder (ASKAP) in its commissioning phase to validate the performance of the telescope and to characterise the detected galaxy populations. This observation covers ~48 deg2 with synthesised beam of 32.7 arcsec by 17.8 arcsec at 936MHz, and ~39 deg2 with synthesised beam of 15.8 arcsec by 12.0 arcsec at 1320MHz. At both frequencies, the root-mean-square (r.m.s.) noise is ~0.1 mJy/beam. We combine these radio observations with the GAMA galaxy data, which includes spectroscopy of galaxies that are i-band selected with a magnitude limit of 19.2. Wide-field Infrared Survey Explorer (WISE) infrared (IR) photometry is used to determine which galaxies host an active galactic nucleus (AGN). In properties including source counts, mass distributions, and IR versus radio luminosity relation, the ASKAP-detected radio sources behave as expected. Radio galaxies have higher stellar mass and luminosity in IR, optical, and UV than other galaxies. We apply optical and IR AGN diagnostics and find that they disagree for ~30% of the galaxies in our sample. We suggest possible causes for the disagreement. Some cases can be explained by optical extinction of the AGN, but for more than half of the cases we do not find a clear explanation. Radio sources aremore likely (~6%) to have an AGN than radio quiet galaxies (~1%), but the majority of AGN are not detected in radio at this sensitivity.
While child self-regulation is shaped by the environment (e.g., the parents’ caregiving behaviors), children also play an active role in influencing the care they receive, indicating that children's individual differences should be integrated in models relating early care to children's development. We assessed 409 children's observed temperamental behavioral inhibition (BI), effortful control (EC), and the primary caregiver's parenting at child ages 3 and 5. Parents reported on child behavior problems at child ages 3, 5, and 8. Mediation analyses were conducted to examine relations between child temperament and parenting in predicting child problems. BI at age 3 was positively associated with structured parenting at age 5, which was negatively related to child internalizing and attention-academic problems at age 8. In contrast, parenting at child age 3 did not predict child BI or EC at age 5, nor did age 3 EC predict parenting at age 5. Findings indicate that child behavior may shape the development of caregiving and, in turn, long-term child adjustment, suggesting that studies of caregiving and child outcomes should consider the role of child temperament toward developing more informative models of child–environment interplay.