Background: Duchenne muscular dystrophy (DMD) is caused by DMD gene mutations. Delandistrogene moxeparvovec is an investigational gene transfer therapy, developed to address the underlying cause of DMD. We report findings from Part 1 (52 weeks) of the two-part EMBARK trial (NCT05096221). Methods: Key inclusion criteria: Ambulatory patients aged ≥4-<8 years with a confirmed DMD mutation within exons 18–79 (inclusive); North Star Ambulatory Assessment (NSAA) score >16 and <29 at screening. Eligible patients were randomized 1:1 to intravenous delandistrogene moxeparvovec (1.33×1014 vg/kg) or placebo. The primary endpoint was change from baseline in NSAA total score to Week 52. Results: At Week 52 (n=125), the primary endpoint did not reach statistical significance, although there was a nominal difference in change from baseline in NSAA total score in the delandistrogene moxeparvovec (2.6, n=63) versus placebo groups (1.9, n=61). Key secondary endpoints (time to rise, micro-dystrophin expression, 10-meter walk/run) demonstrated treatment benefit in both age groups (4-5 and 6-7 years; p<0.05).There were no new safety signals, reinforcing the favorable and manageable safety profile observed to date. Conclusions: Based on the totality of functional assessments including the timed function tests, treatment with delandistrogene moxeparvovec indicates beneficial modification of disease trajectory.

Galaxy gas kinematics are sensitive to the physical processes that contribute to a galaxy’s evolution. It is expected that external processes will cause more significant kinematic disturbances in the outer regions, while internal processes will cause more disturbances for the inner regions. Using a subsample of 47 galaxies ($0.27<z<0.36$) from the Middle Ages Galaxy Properties with Integral Field Spectroscopy (MAGPI) survey, we conduct a study into the source of kinematic disturbances by measuring the asymmetry present in the ionised gas line-of-sight velocity maps at the $0.5R_e$ (inner regions) and $1.5R_e$ (outer regions) elliptical annuli. By comparing the inner and outer kinematic asymmetries, we aim to better understand what physical processes are driving the asymmetries in galaxies. We find the local environment plays a role in kinematic disturbance, in agreement with other integral field spectroscopy studies of the local universe, with most asymmetric systems being in close proximity to a more massive neighbour. We do not find evidence suggesting that hosting an Active Galactic Nucleus contributes to asymmetry within the inner regions, with some caveats due to emission line modelling. In contrast to previous studies, we do not find evidence that processes leading to asymmetry also enhance star formation in MAGPI galaxies. Finally, we find a weak anti-correlation between stellar mass and asymmetry (i.e., high stellar mass galaxies are less asymmetric). We conclude by discussing possible sources driving the asymmetry in the ionised gas, such as disturbances being present in the colder gas phase (either molecular or atomic) prior to the gas being ionised, and non-axisymmetric features (e.g., a bar) being present in the galactic disk. Our results highlight the complex interplay between ionised gas kinematic disturbances and physical processes involved in galaxy evolution.

We present an overview of the Middle Ages Galaxy Properties with Integral Field Spectroscopy (MAGPI) survey, a Large Program on the European Southern Observatory Very Large Telescope. MAGPI is designed to study the physical drivers of galaxy transformation at a lookback time of 3–4 Gyr, during which the dynamical, morphological, and chemical properties of galaxies are predicted to evolve significantly. The survey uses new medium-deep adaptive optics aided Multi-Unit Spectroscopic Explorer (MUSE) observations of fields selected from the Galaxy and Mass Assembly (GAMA) survey, providing a wealth of publicly available ancillary multi-wavelength data. With these data, MAGPI will map the kinematic and chemical properties of stars and ionised gas for a sample of 60 massive ( ${>}7 \times 10^{10} {\mathrm{M}}_\odot$ ) central galaxies at $0.25 < z <0.35$ in a representative range of environments (isolated, groups and clusters). The spatial resolution delivered by MUSE with Ground Layer Adaptive Optics ( $0.6-0.8$ arcsec FWHM) will facilitate a direct comparison with Integral Field Spectroscopy surveys of the nearby Universe, such as SAMI and MaNGA, and at higher redshifts using adaptive optics, for example, SINS. In addition to the primary (central) galaxy sample, MAGPI will deliver resolved and unresolved spectra for as many as 150 satellite galaxies at $0.25 < z <0.35$ , as well as hundreds of emission-line sources at $z < 6$ . This paper outlines the science goals, survey design, and observing strategy of MAGPI. We also present a first look at the MAGPI data, and the theoretical framework to which MAGPI data will be compared using the current generation of cosmological hydrodynamical simulations including EAGLE, Magneticum, HORIZON-AGN, and Illustris-TNG. Our results show that cosmological hydrodynamical simulations make discrepant predictions in the spatially resolved properties of galaxies at $z\approx 0.3$ . MAGPI observations will place new constraints and allow for tangible improvements in galaxy formation theory.

We present the KMOS (K-band Multi-Object Spectrograph) Cluster and VIRIAL (VLT IRIFU Absorption Line) Guaranteed Time Observation (GTO) programs. KMOS provides 24 arms each feeding an integral field unit (14×14 spaxels of 0.2″ pixels) for IZ, YJ, H and K band near infrared (NIR) medium resolution spectroscopy (R ∼ 3500). Targets are selected from a 7.2′ diameter patrol field. Ultra-deep spectroscopy of ∼ 80 early-type cluster galaxies (∼ 20hr on source) and ∼ 200 (∼ 10hr on source) early-type field galaxies at 1 < z < 2 will dramatically improve the situation at z > 1 for which measurements of stellar velocity dispersions and absorption indices are limited to a few, often relatively young passively evolving galaxies (e.g. Bezanson 2013). In ESO Periods P92 and P93, 15 nights worth of data has been collected for KMOS-Clusters and 6 nights for VIRIAL: this will be supplemented with more data in upcoming semesters. All galaxies have multiband HST imaging including existing or upcoming WFC3 IR imaging, providing stellar mass maps and sizes. Combined with our dispersion measurements, this will allow us to examine the fundamental plane and the dynamical mass of a large sample of z > 1 galaxies for the first time, for both cluster and field galaxies.

The physiological age of adult males of seven mealybug species was measured in relation to the elongation of the male pair of the waxy caudal filaments. These filaments begin to emerge after eclosion and reached their maximum length from 29.4–46.6 h. The studied males were divided into three age groups, expressed as percentages of the total waxy caudal filaments length. Attraction to a sex pheromone source was significantly higher in the oldest male group (maximum filaments growth) compared with youngest one. Only the oldest male group copulated successfully; few of the younger males tested displayed 'courtship' behavior towards conspecific virgin females. The calculated duration of the sexually active phase of the adult male life cycle varied among species ranging from 34.4 to 46.6 h. There were marked variations in the strength of attraction to a pheromone source according to time of day. There was a continuous decrease in sexual activity from morning to evening. Our findings reveal clear maturation periods for adult males of the seven studied species. The long immature phase of the adult male mealybug is probably also related to several physiological processes that are needed to complete male maturation. The most noticeable change is the elongation of the waxy caudal filaments. However, mating may be performed at any time ambient conditions are suitable. Whereas male mealybug flight towards a pheromone source is restricted to a few hours, the male may continue mating activity throughout its sexually active period.

We detail an innovative new technique for measuring the 2-D velocity moments (rotation velocity, velocity dispersion and Gauss-Hermite coefficients h3 and h4) using spectra from Keck DEIMOS multi-object spectroscopic observations. The data are used to reconstruct 2-D rotation velocity maps.

In May, 1968, France was saved from revolution not primarily by de Gaulle and his generals but by the French Communist Party. Nine million striking workers occupied the factories. Militants among the students and young unemployed workers had proven themselves more than ready to play the role of vanguard at the barricades. The peasantry had begun to move from passive grumbling to direct action, fearful that the end of agricultural tariffs in July would further depress their hard lot. Even the middleclass professionals, disenchanted with the hierarchical rigidities and the olympian paternalism of Gaullist society had risen to assert their rights to free expression and meaningful participation. All means of communication and transport and all financial agencies were either directly or indirectly under the control of the workers. At will they could have deprived Paris and other cities of food, water, fuel, electricity and gas.

A new treatment of soliton and laminar shock-like structures in single ion species and counter-streaming plasmas in perpendicular magnetic fields is presented. Charge separation effects are treated exactly, and may become important for high Alfvén Mach number flows. The theory contains the familiar quasi-neutrality theory in the limit B20 ≪ Μ0nmec2 and the Longmire theory in the limit B20 ≫ Μ0nmec2. The introduction of the potential ψ as the primary dependent variable, instead of the magnetic field B, clarifies the role of ion dynamics. New pseudo-potential functions are defined which generate classes of solutions for single ion species, rigid piston problems, and multispecies problems. They also provide information about the evolution of particle piston solutions. Results include the fact that a small amount of resistivity allows shock solutions for very large Mach numbers, and for zero dissipation the parameter

does not affect the solutions except in the scale length.

The development of high power ion diodes for inertial confinement fusion is in progress on the PBFA I accelerator. The three main types of magnetically-insulated ion diodes, the Applied-B, Hybrid, and Pinch Reflex diodes, are compared. This paper presents the results from the first series of tests of the Hybrid diode.

Fully electromagnetic, relativistic, two-dimensional, particle-in-cell (PIC) simulations of barrel-type and extractor-type Applied-B ion diodes have increased our confidence in the design of present and future diodes for the Particle Beam Fusion Accelerator II (PBFA II). In addition, the data from various experiments on Pro to I, Proto II, and PBFA I Applied-B ion diodes are inconsistent with previous models of diode operation, based on anode-cathode gap closure from expanding plasmas. A new model has been devised and applied to the PBFA II diode to explain the diode impedance and its time history, and to suggest methods for controlling the impedance.

The Zn substitution on Cu(2) sites in YBa2(Cu1-yZny)3O6+x materials is most probably limited to yzn ≈ 0.04. Results of neutron diffraction associated with NMR and μ+SR results reveal ; i) a lowering of TN in the pure AF region x≤0.20 due to a dilution effect of the antiferromagnetic lattice by a static non magnetic impurity, ii) the existence of a non conventionnal magnetic behavior within the intermediate region x≥0.35 characterized by an unusual temperature dependance of magnetic intensities, a reentrancy and the existence of diffuse magnetic scattering (this region is much broader in oxygen composition for Zn-doped than for pure YBCO),iii) an unusual spin dynamics in the "doped A-F phase" which corresponds to a coupling of magnetic excitations to the hole dynamics.

To compare the safety and antidepressant efficacy of paroxetine, imipramine, and placebo, data from six centres using the same protocol were pooled. A double-blind parallel-group design was used, with therapy lasting six weeks. From week 2 onwards, both the 240 paroxetine-treated and the 237 imipramine-treated patients were significantly different from the 240 placebo-treated patients, but no different from each other. Side-effects with paroxetine were less likely to lead to drop-out than with imipramine. Paroxetine had a possible earlier antidepressant effect than imipramine, and a possible earlier beneficial effect on anxiety symptoms associated with depression.

Characterizations are being conducted on light-water reactor (LWR) spent fuel with peak burnups from ∼31 to 46 MWd/kgM and rod-average fission gas releases of ∼0.3 to 11%. Measured concentrations of nuclides agreed within ∼10 to 15% of the predicted amounts. Radiochemistry of deposits on the cladding interior surface, fuel ceramography, beta/gamma autoradiog-raphy, and gamma scan data were consistent with fuel burnups and apparent operating temperatures. Microstructural observations also indicated increased porosity at the fuel center in high-release fuels and at the edge in high-burnup fuels. Cladding oxide thickness increased with exterior cladding temperatures as did the trend in hydriding.

In an investigation of the relation between life events (stressors) and illness, 87 medical students reported on a prospective basis their health and life events history over a three year period. There were a few positive findings, e.g. that subjects who reported more life events during the period also reported more illnesses during that period. Overall, however, the study showed a lack of statistically significant association between life events and illness.